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Keith D. Robertson

Keith D. Robertson

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
24101
World Ranking
6533
National Ranking
3043

Overview

Keith D. Robertson is affiliated with the Mayo Clinic in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology and hematology as key subfields.

Their work includes significant contributions to epigenetics and DNA methylation, acute myeloid leukemia research, RNA modifications related to cancer, renal cell carcinoma treatment, cancer genomics and diagnostics, liver disease diagnosis and treatment, and ferroptosis and cancer prognosis.

Robertson has published extensively, with some recent notable papers including:

  • Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis (2021, Journal of Clinical Investigation)
  • RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis (2021, Nature Communications)
  • Interferon drives HCV scarring of the epigenome and creates targetable vulnerabilities following viral clearance (2021, Hepatology)
  • The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC (2020, PLoS ONE)
  • Oncogenic gene expression and epigenetic remodeling of cis-regulatory elements in ASXL1-mutant chronic myelomonocytic leukemia (2022, Nature Communications)

Frequent co-authors collaborating with Robertson include:

  • Ryan A. Hlady
  • Moritz Binder
  • Abhishek A. Mangaonkar
  • Mrinal M. Patnaik
  • Jeong-Heon Lee

Robertson's publications appear regularly in specialized journals and venues such as:

  • Cancer Research
  • Hepatology
  • Blood
  • Nature Communications
  • Clinical Epigenetics

The focus on epigenetics and molecular biology research is reflected both in the volume of publications and the selection of research topics spanning cancer, hematology, and liver diseases.

Best Publications

  • DNA METHYLATION AND HUMAN DISEASE

    Keith D. Robertson

  • DNA methylation in health and disease

    Keith D. Robertson;Alan P. Wolffe

  • DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

    Keith D. Robertson;Slimane Ait-Si-Ali;Tomoki Yokochi;Paul A. Wade

  • The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.

    Keith D. Robertson;Eva Uzvolgyi;Gangning Liang;Cathy Talmadge

  • DNA methylation, methyltransferases, and cancer.

    Keith D Robertson

  • DNA methylation: past, present and future directions.

    Keith D. Robertson;Peter A.Jones

  • DNA Methylation: Superior or Subordinate in the Epigenetic Hierarchy?

    Bilian Jin;Yajun Li;Keith D. Robertson

  • DNA methylation and chromatin - unraveling the tangled web.

    Keith D Robertson

  • DNA Methyltransferases, DNA Damage Repair, and Cancer

    Bilian Jin;Keith D. Robertson

  • The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

    Keith D. Robertson;Peter A. Jones

  • DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.

    Stela S. Palii;Beth O. Van Emburgh;Umesh T. Sankpal;Kevin D. Brown

  • Chromatin remodeling, histone modifications, and DNA methylation—how does it all fit together?†

    Theresa M. Geiman;Keith D. Robertson

  • DNA methylation in development and human disease

    Suhasni Gopalakrishnan;Beth O. Van Emburgh;Keith D. Robertson

  • DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function

    Bilian Jin;Qian Tao;Jinrong Peng;Hui Meng Soo

  • Specific Loss of Histone H3 Lysine 9 Trimethylation and HP1γ/Cohesin Binding at D4Z4 Repeats Is Associated with Facioscapulohumeral Dystrophy (FSHD)

    Weihua Zeng;Jessica C. De Greef;Yen Yun Chen;Richard Chien

  • Butyrate suppresses colonic inflammation through HDAC1-dependent Fas Upregulation and Fas-mediated apoptosis of T cells

    Mary A. Zimmerman;Nagendra Singh;Pamela Moore Martin;Muthusamy Thangaraju

  • Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G0/G1 to S phase transition in normal and tumor cells

    Keith D. Robertson;Khandan Keyomarsi;Felicidad A. Gonzales;Mihaela Velicescu

  • Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern.

    Jesus Espada;Esteban Ballestar;Mario F. Fraga;Ana Villar-Garea

  • Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma.

    Tae You Kim;Sheng Zhong;C. Robert Fields;Jeong Hoon Kim

  • Histone Deacetylase Inhibitors for Cancer Therapy

    Tae You Kim;Yung Jue Bang;Keith D. Robertson

Frequent Co-Authors

Chen Liu
Chen Liu Yale University
Terra L. Lasho
Terra L. Lasho Mayo Clinic
Qian Tao
Qian Tao Chinese University of Hong Kong
Richard F. Ambinder
Richard F. Ambinder Johns Hopkins University
Tamas Ordog
Tamas Ordog Mayo Clinic
Peter A. Jones
Peter A. Jones Van Andel Institute
Lewis R. Roberts
Lewis R. Roberts Mayo Clinic
Eric Solary
Eric Solary Institut Gustave Roussy
Ayalew Tefferi
Ayalew Tefferi Mayo Clinic

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