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Molecular Biology

D-Index
76
Citations
27816
World Ranking
1134
National Ranking
589

Overview

Gangning Liang is affiliated with the University of Southern California in the United States. Their research focuses largely on the intersection of molecular biology, genetics, oncology, and medicine, with particular emphasis on epigenetics and its role in cancer development and treatment.

The scientist has contributed significantly to a range of fields, including:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broad fields, they explore several subfields such as:

  • Molecular Biology
  • Surgery
  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Gangning Liang's research tackles multiple specialized topics, among which are:

  • Epigenetics and DNA Methylation
  • Bladder and Urothelial Cancer Treatments
  • RNA modifications and cancer
  • Urinary and Genital Oncology Studies
  • Genomics and Chromatin Dynamics
  • Cancer Genomics and Diagnostics
  • Renal and related cancers

Their recent publications include:

  • "DNA methylation enables transposable element-driven genome expansion" (2020), published in Proceedings of the National Academy of Sciences
  • "Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B" (2020), published in Nature
  • "Comprehensive evaluation of the Infinium human MethylationEPIC v2 BeadChip" (2023), published in Epigenetics Communications
  • "DNMT and EZH2 inhibitors synergize to activate therapeutic targets in hepatocellular carcinoma" (2022), published in Cancer Letters
  • "Characterizing DNA methylation signatures of retinoblastoma using aqueous humor liquid biopsy" (2022), published in Nature Communications

Frequent collaborators in their work include:

  • Hongtao Li
  • Daniel J. Weisenberger
  • Siamak Daneshmand
  • Paolo Piatti
  • Seyedeh-Sanam Ladi-Seyedian

Gangning Liang's publications have appeared repeatedly in specific high-impact venues such as:

  • Cancer Research
  • The Journal of Urology
  • Cancers
  • Urologic Oncology Seminars and Original Investigations
  • Research Square

Best Publications

  • Epigenetics in human disease and prospects for epigenetic therapy

    Gerda Egger;Gangning Liang;Ana Aparicio;Peter A. Jones

  • Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

    Yoshimasa Saito;Gangning Liang;Gerda Egger;Jeffrey M. Friedman

  • DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.

    David Roulois;Helen Loo Yau;Helen Loo Yau;Rajat Singhania;Yadong Wang

  • The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.

    Keith D. Robertson;Eva Uzvolgyi;Gangning Liang;Cathy Talmadge

  • Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

    Xiaojing Yang;Han Han;Daniel D. De Carvalho;Daniel D. De Carvalho;Fides D. Lay

  • Rethinking how DNA methylation patterns are maintained

    Peter A. Jones;Gangning Liang

  • DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

    Tina Branscombe Miranda;Connie C. Cortez;Christine B. Yoo;Gangning Liang

  • Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements.

    Gangning Liang;Matilda F. Chan;Yoshitaka Tomigahara;Yvonne C. Tsai

  • Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome.

    Gangning Liang;Joy C. Y. Lin;Vivian Wei;Christine Yoo

  • Histone H3-Lysine 9 Methylation Is Associated with Aberrant Gene Silencing in Cancer Cells and Is Rapidly Reversed by 5-Aza-2′-deoxycytidine

    Carvell T. Nguyen;Daniel J. Weisenberger;Mihaela Velicescu;Felicidad A. Gonzales

  • The putative tumor suppressor microrna-101 modulates the cancer epigenome by repressing the polycomb group protein ezh2.

    Jeffrey J. Friedman;Gangning Liang;Peter A. Jones

  • Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules

    Theresa K. Kelly;Yaping Liu;Fides D. Lay;Gangning Liang

  • Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line.

    Einav Nili Gal-Yam;Gerda Egger;Leo Iniguez;Heather Holster

  • Preferential response of cancer cells to zebularine

    Jonathan C. Cheng;Christine B. Yoo;Daniel J. Weisenberger;Jody Chuang

  • Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer.

    Erika M. Wolff;Hyang-Min Byun;Han F. Han;Shikhar Sharma

  • DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival

    Daniel D. De Carvalho;Shikhar Sharma;Jueng Soo You;Sheng-Fang Su

  • Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells.

    Jonathan C. Cheng;Daniel J. Weisenberger;Felicidad A. Gonzales;Gangning Liang

  • Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells

    Yoshimasa Saito;Jeffrey M. Friedman;Yoshitomo Chihara;Gerda Egger

  • Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island.

    Joy C. Lin;Shinwu Jeong;Gangning Liang;Daiya Takai

  • Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival

    Gerda Egger;Shinwu Jeong;Sonia G. Escobar;Connie C. Cortez

Frequent Co-Authors

Peter A. Jones
Peter A. Jones Van Andel Institute
Daniel J. Weisenberger
Daniel J. Weisenberger University of Southern California
Kimberly D. Siegmund
Kimberly D. Siegmund University of Southern California
Inderbir S. Gill
Inderbir S. Gill University of Southern California
Peter W. Laird
Peter W. Laird Van Andel Institute
Peter Jones
Peter Jones University of Cambridge
Wanding Zhou
Wanding Zhou University of Pennsylvania
Mihir M. Desai
Mihir M. Desai University of Southern California
Heinz-Josef Lenz
Heinz-Josef Lenz University of Southern California
Torben F. Ørntoft
Torben F. Ørntoft Aarhus University

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