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Walter Doerfler

Walter Doerfler

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Genetics and Molecular Biology
Germany
2024

D-Index & Metrics

Microbiology

D-Index
74
Citations
19451
World Ranking
1582
National Ranking
113

Molecular Biology

D-Index
74
Citations
19326
World Ranking
1230
National Ranking
95

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Germany Leader Award
  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1997 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Human Genetics and Molecular Medicine
  • 1984 - Robert Koch Prize
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Walter Doerfler is affiliated with the University of Cologne in Germany. Their research spans multiple fields within biochemistry, genetics, molecular biology, and medicine, with significant contributions focused on molecular biology and infectious diseases.

The scientist's main research topics include:

  • CRISPR and Genetic Engineering
  • SARS-CoV-2 and COVID-19 Research
  • Bacteriophages and microbial interactions
  • Epigenetics and DNA Methylation
  • Virus-based gene therapy research
  • Plant Virus Research Studies
  • Vaccines and immunoinformatics approaches

Regarding publication venues where their work frequently appears, these include:

  • Virus Research
  • EMBO Molecular Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Viruses
  • Clinical Epigenetics

Walter Doerfler has coauthored with several researchers repeatedly, including:

  • Stefanie Weber
  • Christina M. Ramirez
  • Barbara Weiser
  • Harold Burger

The following are a selection of recent papers authored or coauthored by Walter Doerfler:

  • Adenoviral Vector DNA- and SARS-CoV-2 mRNA-Based Covid-19 Vaccines: Possible Integration into the Human Genome - Are Adenoviral Genes Expressed in Vector-based Vaccines?, 2021, Virus Research
  • Essential concepts are missing: Foreign DNA in food invades the organisms' cells and can lead to stochastic epigenetic alterations with a wide range of possible pathogenetic consequences, 2020, Clinical Epigenetics

Additional relevant publications by close collaborators include:

  • Signal hotspot mutations in SARS-CoV-2 genomes evolve as the virus spreads and actively replicates in different parts of the world, 2020, Virus Research
  • SARS-CoV-2 worldwide replication drives rapid rise and selection of mutations across the viral genome: a time-course study - potential challenge for vaccines and therapies, 2021, EMBO Molecular Medicine
  • SARS-CoV-2 Worldwide Replication Drives Rapid Rise and Selection of Mutations across the Viral Genome: A Time-Course Study Potential Challenge for Vaccines and Therapies, 2021, bioRxiv (Cold Spring Harbor Laboratory)

Walter Doerfler's work has been recognized through various awards and memberships, including:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2007
  • Election to the German National Academy of Sciences Leopoldina - specializing in Human Genetics and Molecular Medicine, 1997
  • Recipient of the Robert Koch Prize, 1984
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • DNA methylation and gene activity

    Walter Doerfler

  • Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses

    S Karlin;W Doerfler;L R Cardon

  • Foreign (M13) DNA ingested by mice reaches peripheral leukocytes, spleen, and liver via the intestinal wall mucosa and can be covalently linked to mouse DNA

    Rainer Schubbert;Doris Renz;Birgit Schmitz;Walter Doerfler

  • Methylation of integrated adenovirus type 12 DNA sequences in transformed cells is inversely correlated with viral gene expression.

    Diane Sutter;Walter Doerfler

  • Ingested foreign (phage M13) DNA survives transiently in the gastrointestinal tract and enters the bloodstream of mice.

    Rainer Schubbert;Clarissa Lettmann;Walter Doerfler

  • On the fate of orally ingested foreign DNA in mice: chromosomal association and placental transmission to the fetus.

    R. Schubbert;U. Hohlweg;D. Renz;W. Doerfler

  • The oligosaccharides of influenza virus hemagglutinin expressed in insect cells by a baculovirus vector

    Kazumichi Kuroda;Hildegard Geyer;Rudolf Geyer;Walter Doerfler

  • Nonproductive infection of baby hamster kidney cells (BHK21) with adenovirus type 12.

    Walter Doerfler

  • DNA methylation--a regulatory signal in eukaryotic gene expression

    Walter Doerfler

  • Expression of the influenza virus haemagglutinin in insect cells by a baculovirus vector.

    K. Kuroda;C. Hauser;R. Rott;H.D. Klenk

  • Expression of a cloned adenovirus gene is inhibited by in vitro methylation.

    L Vardimon;A Kressmann;H Cedar;M Maechler

  • Neurological phenotype in Waardenburg syndrome type 4 correlates with novel SOX10 truncating mutations and expression in developing brain.

    Renaud L. Touraine;Tania Attié-Bitach;Eric Manceau;Eckhard Korsch

  • Imprinted Segments in the Human Genome: Different Dna Methylation Patterns in the Prader-Willi/Angelman Syndrome Region As Determined by the Genomic Sequencing Method

    Michael Zeschnigk;Birgit Schmitz;Bärbel Dittrich;Karin Buiting

  • DNA methylation in the Alu sequences of diploid and haploid primary human cells

    S Kochanek;D Renz;W Doerfler

  • A single-tube PCR test for the diagnosis of Angelman and Prader-Willi syndrome based on allelic methylation differences at the SNRPN locus.

    Michael Zeschnigk;Christina Lich;Karin Buiting;Walter Doerfler

  • Structure and composition of the adenovirus type 2 core.

    D T Brown;M Westphal;B T Burlingham;U Winterhoff

  • Patterns of integration of viral dna sequences in the genomes of adenovirus type 12-transformed hamster cells

    Diane Sutter;Monika Westphal;Walter Doerfler

  • Infection of Spodoptera frugiperda cells with Autographa californica nuclear polyhedrosis virus I. Synthesis of intracellular proteins after virus infection.

    Eric B. Carstens;Sian T. Tjia;Walter Doerfler

  • Expression of the chloramphenicol acetyltransferase gene in mammalian cells under the control of adenovirus type 12 promoters: effect of promoter methylation on gene expression

    Inge Kruczek;Walter Doerfler

  • A rapid optimized protocol for downward alkaline Southern blotting of DNA.

    P A Koetsier;J Schorr;W Doerfler

Frequent Co-Authors

Stefan Kochanek
Stefan Kochanek University of Ulm
Bernd Weisshaar
Bernd Weisshaar Bielefeld University
Miklós Tóth
Miklós Tóth Cornell University
Ulrich Müller
Ulrich Müller Johns Hopkins University School of Medicine
Hermann Lübbert
Hermann Lübbert Biofrontera (Germany)
Thomas Klimkait
Thomas Klimkait University of Basel
Karin Buiting
Karin Buiting University of Duisburg-Essen
Per Hoffmann
Per Hoffmann University of Bonn
Bernhard Horsthemke
Bernhard Horsthemke University of Duisburg-Essen
Jörg Tatzelt
Jörg Tatzelt Ruhr University Bochum

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