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Ricardo E. Dolmetsch

Ricardo E. Dolmetsch

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
23864
World Ranking
15890
National Ranking
293

Research.com Recognitions

  • 2008 - National Institutes of Health Director's Pioneer Award

Overview

Ricardo E. Dolmetsch is affiliated with Novartis (Switzerland) and has conducted extensive research primarily in the fields of Biochemistry, Genetics, and Molecular Biology, with significant work also within Medicine. Their research contributions span key subfields such as Molecular Biology, Genetics, Cellular and Molecular Neuroscience, Neurology, and Hematology.

Their work addresses several main topics, including congenital heart defects research, genetic neurodegenerative diseases, genomic variations and chromosomal abnormalities, genetics and neurodevelopmental disorders, hemophilia treatment and research, virus-based gene therapy research, and CAR-T cell therapy research.

Dolmetsch has published research in multiple venues, with frequent publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Value in Health
  • Nature Communications
  • Neurology Clinical Practice
  • UNC Libraries

Significant recent papers include:

  • Gene Therapy with Etranacogene Dezaparvovec for Hemophilia B, 2023, New England Journal of Medicine
  • Neuronal defects in a human cellular model of 22q11.2 deletion syndrome, 2020, Nature Medicine
  • An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion, 2022, Nature Communications
  • The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia, 2022, Nature Communications
  • Stable and durable factor IX levels in patients with hemophilia B over 3 years after etranacogene dezaparvovec gene therapy, 2022, Blood Advances

Frequent coauthors in their research include:

  • Samuel Frank
  • Jamie Hamilton
  • Hayley Hubberstey
  • Sarah Ratsch
  • Yishan Sun

Ricardo E. Dolmetsch's work reflects a breadth of investigation into molecular and genetic mechanisms underlying various medical conditions, with a notable emphasis on neurological and hematological disorders.

In 2008, they were awarded the National Institutes of Health Director's Pioneer Award, recognizing their contributions to scientific research.

Best Publications

  • Differential activation of transcription factors induced by Ca2+ response amplitude and duration

    Ricardo E. Dolmetsch;Richard S. Lewis;Christopher C. Goodnow;James I. Healy

  • Calcium oscillations increase the efficiency and specificity of gene expression

    Ricardo E. Dolmetsch;Keli Xu;Richard S. Lewis

  • Calcium regulation of neuronal gene expression.

    Anne E. West;Wen G. Chen;Matthew B. Dalva;Ricardo E. Dolmetsch

  • STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

    Chan Young Park;Paul J. Hoover;Franklin M. Mullins;Priti Bachhawat

  • MicroRNA-mediated conversion of human fibroblasts to neurons

    Andrew S. Yoo;Alfred X. Sun;Li Li;Aleksandr Shcheglovitov

  • Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway

    Ricardo E. Dolmetsch;Urvi Pajvani;Katherine Fife;James M. Spotts

  • Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

    Çagla Eroglu;Çagla Eroglu;Nicola J. Allen;Michael W. Susman;Nancy A. O'Rourke

  • p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

    Robert J. Ihry;Kathleen A. Worringer;Max R. Salick;Elizabeth Frias

  • LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

    Ha Nam Nguyen;Blake Byers;Branden Cord;Aleksandr Shcheglovitov

  • Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy

    Ning Sun;Masayuki Yazawa;Jianwei Liu;Leng Han

  • Gene regulation mediated by calcium signals in T lymphocytes.

    Stefan Feske;Jena Giltnane;Ricardo Dolmetsch;Louis M. Staudt

  • Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

    Masayuki Yazawa;Brian Hsueh;Brian Hsueh;Xiaolin Jia;Xiaolin Jia;Anca M. Pasca;Anca M. Pasca

  • Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

    Sergiu P Paşca;Thomas Portmann;Irina Voineagu;Masayuki Yazawa

  • SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients

    Aleksandr Shcheglovitov;Olesya Shcheglovitova;Masayuki Yazawa;Thomas Portmann

  • Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

    James I Healy;Ricardo E Dolmetsch;Luika A Timmerman;Jason G Cyster

  • The C Terminus of the L-Type Voltage-Gated Calcium Channel CaV1.2 Encodes a Transcription Factor

    Natalia Gomez-Ospina;Fuminori Tsuruta;Odmara Barreto-Chang;Linda Hu

  • Induction of protein-protein interactions in live cells using light

    Masayuki Yazawa;Amir M Sadaghiani;Brian Hsueh;Brian Hsueh;Ricardo E Dolmetsch

  • CREB Transcriptional Activity in Neurons Is Regulated by Multiple, Calcium-Specific Phosphorylation Events

    Jon M. Kornhauser;Christopher W. Cowan;Adam J. Shaywitz;Ricardo E. Dolmetsch

  • The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels

    Chan Young Park;Aleksandr Shcheglovitov;Ricardo Dolmetsch

  • Gabapentin Receptor alpha 2 delta-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

    Cagla Eroglu;Nicola J. Allen;Michael W. Susman;Nancy A. O'Rourke

Frequent Co-Authors

Richard S. Lewis
Richard S. Lewis Stanford University
Joachim Hallmayer
Joachim Hallmayer Stanford University
Jonathan A. Bernstein
Jonathan A. Bernstein University of Cincinnati Medical Center
Theo D. Palmer
Theo D. Palmer Stanford University
Daniel H. Geschwind
Daniel H. Geschwind University of California, Los Angeles
David A. Collier
David A. Collier Eli Lilly (United States)
Carrie E. Bearden
Carrie E. Bearden University of California, Los Angeles
Michael E. Greenberg
Michael E. Greenberg Harvard University
Patrick F. Sullivan
Patrick F. Sullivan University of North Carolina at Chapel Hill
Alan Anticevic
Alan Anticevic Yale University

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