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D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
14736
World Ranking
10188
National Ranking
736

Research.com Recognitions

  • 2009 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Physiology and Pharmacology/Toxicology

Overview

Markus Hoth is affiliated with Saarland University in Germany and has a broad research profile spanning several interrelated biomedical fields. Their work encompasses studies across Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology, with a notable focus on Immunology as a subfield.

The research topics Markus Hoth has focused on include diverse areas within immune cell biology and related medical applications. These topics are:

  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • Cellular Mechanics and Interactions
  • T-cell and B-cell Immunology
  • Lymphoma Diagnosis and Treatment
  • Ion Channels and Receptors
  • Cell Adhesion Molecules Research

Their frequent coauthors include Bin Qu, Renping Zhao, Eva C. Schwarz, Lorenz Thurner, and Gertrud Schäfer, reflecting ongoing collaborative networks within their research domain.

Most of Markus Hoth's publications appear in venues related to immunology, cell biology, and biophysics. Notable frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Frontiers in Oncology
  • eJHaem
  • Biophysical Journal

Some recent representative papers from Markus Hoth's work include:

  • Migration of Cytotoxic T Lymphocytes in 3D Collagen Matrices (2020, Biophysical Journal)
  • Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic CD8+ T cells boost cancer cell elimination (2022, Aging Cell)
  • Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry (2020, Cell Reports)
  • A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity (2021, Seminars in Cell and Developmental Biology)
  • Optoregulated force application to cellular receptors using molecular motors (2021, Nature Communications)

The scope of their work reflects cross-disciplinary approaches combining cellular and molecular biology techniques with immunological and biophysical methodologies. This includes research on the mechanics of immune cells, signaling pathways involving ion channels, and their implications for cancer and immune therapies.

In 2009, Markus Hoth received recognition from the German National Academy of Sciences Leopoldina in the category of Physiology and Pharmacology/Toxicology.

Best Publications

  • DEPLETION OF INTRACELLULAR CALCIUM STORES ACTIVATES A CALCIUM CURRENT IN MAST-CELLS

    Markus Hoth;Reinhold Penner

  • Calcium release-activated calcium current in rat mast cells.

    M Hoth;R Penner

  • Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

    Alexander Roesch;Adina Vultur;Ivan Bogeski;Huan Wang

  • Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes

    Markus Hoth;Christopher M. Fanger;Richard S. Lewis

  • T cell activation requires mitochondrial translocation to the immunological synapse

    Ariel Quintana;Christian Schwindling;Anna S. Wenning;Ute Becherer

  • A GTP-dependent step in the activation mechanism of capacitative calcium influx.

    C Fasolato;M Hoth;R Penner

  • Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2.

    Christof Zitt;Bettina Strauss;Eva C. Schwarz;Nicola Spaeth

  • Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure

    Alexander G. Nickel;Albrecht Von Hardenberg;Mathias Hohl;Joachim R. Löffler

  • Mitochondrial control of calcium-channel gating: A mechanism for sustained signaling and transcriptional activation in T lymphocytes

    Markus Hoth;Donald C. Button;Richard S. Lewis

  • Square-Wave Voltammetry: A Review on the Recent Progress

    Valentin Mirceski;Rubin Gulaboski;Milivoj Lovric;Ivan Bogeski

  • Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling

    Ivan Bogeski;Carsten Kummerow;Dalia Al-Ansary;Eva C. Schwarz

  • Red fluorescent genetically encoded indicator for intracellular hydrogen peroxide

    Yulia G. Ermakova;Dmitry S. Bilan;Mikhail E. Matlashov;Natalia M. Mishina

  • Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.

    C M Fanger;M Hoth;G R Crabtree;R S Lewis

  • Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T‐cell activation

    Ariel Quintana;Mathias Pasche;Christian Junker;Dalia Al-Ansary

  • TRP4 (CCE1) Protein Is Part of Native Calcium Release-activated Ca2+-like Channels in Adrenal Cells

    Stephan Philipp;Claudia Trost;Jan Warnat;Julia Rautmann

  • Non-specific effects of calcium entry antagonists in mast cells.

    Dorothee Franzius;Markus Hoth;Reinhold Penner

  • Calcium influx and its control by calcium release

    Reinhold Penner;Cristina Fasolato;Markus Hoth

  • Sustained activity of calcium release-activated calcium channels requires translocation of mitochondria to the plasma membrane.

    Ariel Quintana;Eva C. Schwarz;Christian Schwindling;Peter Lipp

  • Ca2+ and Mn2+ influx through receptor-mediated activation of nonspecific cation channels in mast cells.

    Cristina Fasolato;Markus Hoth;Gary Matthews;Reinhold Penner

  • The neglected CRAC proteins: Orai2, Orai3, and STIM2.

    Markus Hoth;Barbara A. Niemeyer

Frequent Co-Authors

Jens Rettig
Jens Rettig Saarland University
Frank Müller
Frank Müller Forschungszentrum Jülich
Rainer Deutzmann
Rainer Deutzmann University of Regensburg
Reinhold Penner
Reinhold Penner Queen's Medical Center
Veit Flockerzi
Veit Flockerzi Saarland University
Richard S. Lewis
Richard S. Lewis Stanford University
Martina Sester
Martina Sester Saarland University
Barbara Burwinkel
Barbara Burwinkel Heidelberg University
Eckart Meese
Eckart Meese Saarland University
Aránzazu del Campo
Aránzazu del Campo Leibniz Association

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