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D-Index & Metrics

Chemistry

D-Index
52
Citations
12988
World Ranking
13387
National Ranking
3510

Overview

John O. Trent is affiliated with the University of Louisville in the United States and has an extensive research background within the fields of Biochemistry, Genetics and Molecular Biology. Their work primarily focuses on Molecular Biology, with significant contributions also found in Cancer Research, Oncology, Pulmonary and Respiratory Medicine, and Periodontics.

The scientist's research covers a range of topics including DNA and Nucleic Acid Chemistry, Advanced biosensing and bioanalysis techniques, RNA and protein synthesis mechanisms, RNA Interference and Gene Delivery, Cancer, Hypoxia, and Metabolism, Cancer-related Molecular Pathways, and Advanced Breast Cancer Therapies.

John O. Trent has published multiple papers in well-known scientific journals. Recent works include:

  • The hTERT core promoter forms three parallel G-quadruplexes (2020), Nucleic Acids Research
  • G-quadruplex DNA: A Longer Story (2022), Accounts of Chemical Research
  • The solution structures of higher-order human telomere G-quadruplex multimers (2021), Nucleic Acids Research
  • Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences (2022), Nucleic Acids Research
  • Identification of a Heme Activation Site on the MD-2/TLR4 Complex (2020), Frontiers in Immunology

Their frequent coauthors include Robert C. Monsen, Jonathan B. Chaires, Lynn DeLeeuw, William L. Dean, and Robert D. Gray.

Major venues where John O. Trent has published work include:

  • Nucleic Acids Research
  • Cancer Research
  • PLoS ONE
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cancer Research

Best Publications

  • Discovery and Development of the G-rich Oligonucleotide AS1411 as a Novel Treatment for Cancer

    Paula J. Bates;Damian A. Laber;Donald M. Miller;Shelia D. Thomas

  • Inhibition of human telomerase by a G-quadruplex-interactive compound.

    Daekyu Sun;Brian Thompson;Brian E. Cathers;Miguel Salazar

  • Stability and kinetics of G-quadruplex structures

    Andrew N. Lane;J. Brad Chaires;Robert D. Gray;John O. Trent

  • Antiproliferative Activity of G-rich Oligonucleotides Correlates with Protein Binding *

    Paula J. Bates;Jasbir B. Kahlon;Shelia D. Thomas;John O. Trent

  • G-Quadruplex Secondary Structure Obtained from Circular Dichroism Spectroscopy.

    Rafael del Villar-Guerra;John O. Trent;Jonathan B. Chaires

  • Biophysical and biological properties of quadruplex oligodeoxyribonucleotides.

    Virna Đapić;Vedra Abdomerović;Rachel Marrington;Jemma Peberdy

  • Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal

    Jing-Jing Li;John J. Correia;Lei Wang;John O. Trent

  • G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms.

    Paula J. Bates;Elsa M. Reyes-Reyes;Mohammad T. Malik;Emily M. Murphy

  • Intercalative G-Tetraplex Stabilization of Telomeric DNA by a Cationic Porphyrin1

    Ihtshamul Haq;John O. Trent;and Babur Z. Chowdhry;Terence C. Jenkins

  • Molecular‐Size Reduction of a Potent CXCR4‐Chemokine Antagonist Using Orthogonal Combination of Conformation‐ and Sequence‐Based Libraries

    Nobutaka Fujii;Shinya Oishi;Kenichi Hiramatsu;Takanobu Araki

  • Molecular docking of intercalators and groove-binders to nucleic acids using Autodock and Surflex.

    Patrick A. Holt;Jonathan B. Chaires;John O. Trent

  • Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor–coactivator interactions

    Anne-Marie Leduc;John O. Trent;James L. Wittliff;Kelli S. Bramlett

  • Folding and unfolding pathways of the human telomeric G-quadruplex.

    Robert D. Gray;John O. Trent;Jonathan B. Chaires

  • Inhibition of DNA replication and induction of S phase cell cycle arrest by G-rich oligonucleotides.

    Xiaohua Xu;Fofi Hamhouyia;Shelia D. Thomas;Tom J. Burke

  • Human Telomerase Inhibition by Regioisomeric Disubstituted Amidoanthracene-9,10-diones

    Philip J. Perry;Anthony P. Reszka;Alexis A. Wood;Martin A. Read

  • Structure and Stability of Higher-Order Human Telomeric Quadruplexes

    Luigi Petraccone;Charles Spink;John O. Trent;Nichola C. Garbett

  • Allosteric, chiral-selective drug binding to DNA.

    Xiaogang Qu;John O. Trent;Izabela Fokt;Waldemar Priebe

  • Antiproliferative activity of G-quartet-forming oligonucleotides with backbone and sugar modifications.

    Virna Dapic;Paula J. Bates;John O. Trent;Alison Rodger

  • A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells

    Millicent Winner;Jason Meier;Swen Zierow;Beatriz E. Rendon

  • Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists.

    John O. Trent;Zi-xuan Wang;James L. Murray;Wenhai Shao

  • Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection

    Robert Buscaglia;M. Clarke Miller;William L. Dean;Robert D. Gray

  • Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists.

    Hirokazu Tamamura;Kenichi Hiramatsu;Makiko Mizumoto;Satoshi Ueda

  • Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities.

    Satoshi Ueda;Shinya Oishi;Zi-xuan Wang;Takanobu Araki

  • The tail of the telomere.

    Luigi Petraccone;John O. Trent;Jonathan B. Chaires

  • Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds.

    Hirokazu Tamamura;Takanobu Araki;Satoshi Ueda;Zixuan Wang

  • Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131

    Hirokazu Tamamura;Kenichi Hiramatsu;Satoshi Ueda;Zixuan Wang

  • Tiny telomere DNA

    Jinsong Ren;Xiaogang Qu;John O. Trent;Jonathan B. Chaires

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