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John O. Trent

D-Index & Metrics

Chemistry

D-Index
52
Citations
12988
World Ranking
13385
National Ranking
3509

John O. Trent publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where John O. Trent sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 133 publications — 9th percentile

9% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

John O. Trent D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where John O. Trent sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 52 D-Index — 26th percentile

26% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

John O. Trent is affiliated with the University of Louisville in the United States and has an extensive research background within the fields of Biochemistry, Genetics and Molecular Biology. Their work primarily focuses on Molecular Biology, with significant contributions also found in Cancer Research, Oncology, Pulmonary and Respiratory Medicine, and Periodontics.

The scientist's research covers a range of topics including DNA and Nucleic Acid Chemistry, Advanced biosensing and bioanalysis techniques, RNA and protein synthesis mechanisms, RNA Interference and Gene Delivery, Cancer, Hypoxia, and Metabolism, Cancer-related Molecular Pathways, and Advanced Breast Cancer Therapies.

John O. Trent has published multiple papers in well-known scientific journals. Recent works include:

  • The hTERT core promoter forms three parallel G-quadruplexes (2020), Nucleic Acids Research
  • G-quadruplex DNA: A Longer Story (2022), Accounts of Chemical Research
  • The solution structures of higher-order human telomere G-quadruplex multimers (2021), Nucleic Acids Research
  • Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences (2022), Nucleic Acids Research
  • Identification of a Heme Activation Site on the MD-2/TLR4 Complex (2020), Frontiers in Immunology

Their frequent coauthors include Robert C. Monsen, Jonathan B. Chaires, Lynn DeLeeuw, William L. Dean, and Robert D. Gray.

Major venues where John O. Trent has published work include:

  • Nucleic Acids Research
  • Cancer Research
  • PLoS ONE
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cancer Research

Best Publications

  • Discovery and Development of the G-rich Oligonucleotide AS1411 as a Novel Treatment for Cancer

    Paula J. Bates;Damian A. Laber;Donald M. Miller;Shelia D. Thomas

  • Inhibition of human telomerase by a G-quadruplex-interactive compound.

    Daekyu Sun;Brian Thompson;Brian E. Cathers;Miguel Salazar

  • Stability and kinetics of G-quadruplex structures

    Andrew N. Lane;J. Brad Chaires;Robert D. Gray;John O. Trent

  • Antiproliferative Activity of G-rich Oligonucleotides Correlates with Protein Binding *

    Paula J. Bates;Jasbir B. Kahlon;Shelia D. Thomas;John O. Trent

  • G-Quadruplex Secondary Structure Obtained from Circular Dichroism Spectroscopy.

    Rafael del Villar-Guerra;John O. Trent;Jonathan B. Chaires

  • Biophysical and biological properties of quadruplex oligodeoxyribonucleotides.

    Virna Đapić;Vedra Abdomerović;Rachel Marrington;Jemma Peberdy

  • Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal

    Jing-Jing Li;John J. Correia;Lei Wang;John O. Trent

  • G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms.

    Paula J. Bates;Elsa M. Reyes-Reyes;Mohammad T. Malik;Emily M. Murphy

  • Intercalative G-Tetraplex Stabilization of Telomeric DNA by a Cationic Porphyrin1

    Ihtshamul Haq;John O. Trent;and Babur Z. Chowdhry;Terence C. Jenkins

  • Molecular‐Size Reduction of a Potent CXCR4‐Chemokine Antagonist Using Orthogonal Combination of Conformation‐ and Sequence‐Based Libraries

    Nobutaka Fujii;Shinya Oishi;Kenichi Hiramatsu;Takanobu Araki

  • Molecular docking of intercalators and groove-binders to nucleic acids using Autodock and Surflex.

    Patrick A. Holt;Jonathan B. Chaires;John O. Trent

  • Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor–coactivator interactions

    Anne-Marie Leduc;John O. Trent;James L. Wittliff;Kelli S. Bramlett

  • Folding and unfolding pathways of the human telomeric G-quadruplex.

    Robert D. Gray;John O. Trent;Jonathan B. Chaires

  • Inhibition of DNA replication and induction of S phase cell cycle arrest by G-rich oligonucleotides.

    Xiaohua Xu;Fofi Hamhouyia;Shelia D. Thomas;Tom J. Burke

  • Human Telomerase Inhibition by Regioisomeric Disubstituted Amidoanthracene-9,10-diones

    Philip J. Perry;Anthony P. Reszka;Alexis A. Wood;Martin A. Read

  • Structure and Stability of Higher-Order Human Telomeric Quadruplexes

    Luigi Petraccone;Charles Spink;John O. Trent;Nichola C. Garbett

  • Allosteric, chiral-selective drug binding to DNA.

    Xiaogang Qu;John O. Trent;Izabela Fokt;Waldemar Priebe

  • Antiproliferative activity of G-quartet-forming oligonucleotides with backbone and sugar modifications.

    Virna Dapic;Paula J. Bates;John O. Trent;Alison Rodger

  • A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells

    Millicent Winner;Jason Meier;Swen Zierow;Beatriz E. Rendon

  • Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists.

    John O. Trent;Zi-xuan Wang;James L. Murray;Wenhai Shao

  • Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection

    Robert Buscaglia;M. Clarke Miller;William L. Dean;Robert D. Gray

  • Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists.

    Hirokazu Tamamura;Kenichi Hiramatsu;Makiko Mizumoto;Satoshi Ueda

  • Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities.

    Satoshi Ueda;Shinya Oishi;Zi-xuan Wang;Takanobu Araki

  • The tail of the telomere.

    Luigi Petraccone;John O. Trent;Jonathan B. Chaires

  • Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds.

    Hirokazu Tamamura;Takanobu Araki;Satoshi Ueda;Zixuan Wang

  • Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131

    Hirokazu Tamamura;Kenichi Hiramatsu;Satoshi Ueda;Zixuan Wang

  • Tiny telomere DNA

    Jinsong Ren;Xiaogang Qu;John O. Trent;Jonathan B. Chaires

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