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Biology and Biochemistry

D-Index
54
Citations
13789
World Ranking
15450
National Ranking
1216

Research.com Recognitions

  • 2019 - Fellow of the Royal Society, United Kingdom
  • 2002 - Member of Academia Europaea

Overview

Anant B. Parekh is a researcher affiliated with the University of Oxford in the United Kingdom. Their work spans the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine, with a focus on Molecular Biology, Cellular and Molecular Neuroscience, Rheumatology, Sensory Systems, and Cardiology and Cardiovascular Medicine.

The research conducted by Parekh predominantly involves the regulation and function of ion channels. Core topics of investigation include Ion channel regulation and function, Ion Channels and Receptors, Neuroscience and Neuropharmacology Research, Photoreceptor and optogenetics research, Cardiac electrophysiology and arrhythmias, Receptor Mechanisms and Signaling, and Poisoning and overdose treatments.

Parekh has collaborated frequently with several coauthors, including Yu-Ping Lin, Charles J. Tucker, Pulak Kar, Krishna Samanta, and Gary S. Bird.

Their publication record covers multiple venues, with repeated contributions to Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature. Other venues include Current Opinion in Physiology, bioRxiv (Cold Spring Harbor Laboratory), Function, and the Journal of Clinical Orthopaedics.

Recent papers authored or recommended by Parekh include:

  • "Cytosolic and intra-organellar Ca2+ oscillations: mechanisms and function" (2020), published in Current Opinion in Physiology
  • "Scrutinizing science to save lives: uncovering flaws in the data linking L-type calcium channels blockers to CRAC channels and heart failure" (2024), published in bioRxiv (Cold Spring Harbor Laboratory)
  • "Sequi Ad Maius Bonum; Targeting Ion Channels in the Lung" (2020), published in Function
  • "Faculty Opinions recommendation of The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration." (2021), published in Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • "Faculty Opinions recommendation of SARS-CoV-2 S Protein Subunit 1 Elicits Ca2+ Influx - Dependent Ca2+ Signals in Pancreatic Stellate Cells and Macrophages In Situ." (2022), published in Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature

Among awards received, Parekh was named a Fellow of the Royal Society, United Kingdom, in 2019 and became a Member of Academia Europaea in 2002.

Best Publications

  • Store-operated calcium channels.

    Anant B. Parekh;James W. Putney

  • Store depletion and calcium influx

    A. B. Parekh;R. Penner

  • Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger

    Anant B. Parekh;Heinrich Terlau;Walter Stühmer

  • Store-operated CRAC channels: function in health and disease

    Anant B. Parekh

  • Store-operated Ca2+ entry: dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane.

    Anant B. Parekh

  • Ca2+ microdomains near plasma membrane Ca2+ channels: impact on cell function

    Anant B. Parekh

  • Decoding cytosolic Ca2+ oscillations

    Anant B. Parekh

  • Store‐operated Ca2+ entry depends on mitochondrial Ca2+ uptake

    Maike D. Glitsch;Daniel Bakowski;Anant B. Parekh

  • Respiring mitochondria determine the pattern of activation and inactivation of the store-operated Ca(2+) current I(CRAC).

    Juan A. Gilabert;Anant B. Parekh

  • THE STORE-OPERATED CALCIUM CURRENT ICRAC : NONLINEAR ACTIVATION BY INSP3 AND DISSOCIATION FROM CALCIUM RELEASE

    Anant B Parekh;Andrea Fleig;Reinhold Penner

  • Cloning and functional characterization of the rat stomach fundus serotonin receptor.

    M. Foguet;D. Hoyer;L.A. Pardo;A. Parekh

  • Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells

    Anant B. Parekh;Reinhold Penner

  • An examination of the secretion-like coupling model for the activation of the Ca2+ release-activated Ca2+ current I(CRAC) in RBL-1 cells.

    Daniel Bakowski;Maike D. Glitsch;Anant B. Parekh

  • Decoding of Cytoplasmic Ca2+ Oscillations through the Spatial Signature Drives Gene Expression

    Joseph Di Capite;Siaw Wei Ng;Anant B. Parekh

  • Biphasic Regulation of Mitochondrial Ca2+ Uptake by Cytosolic Ca2+ Concentration

    Ben Moreau;Charmaine Nelson;Anant B. Parekh

  • Distinct Spatial Ca2+ Signatures Selectively Activate Different NFAT Transcription Factor Isoforms

    Pulak Kar;Anant B. Parekh

  • Fair and efficient packet scheduling using Elastic Round Robin

    S.S. Kanhere;H. Sethu;A.B. Parekh

  • Selective activation of the transcription factor NFAT1 by calcium microdomains near Ca2+ release-activated Ca2+ (CRAC) channels.

    Pulak Kar;Charmaine Nelson;Anant B. Parekh

  • Energized mitochondria increase the dynamic range over which inositol 1,4,5-trisphosphate activates store-operated calcium influx.

    Juan A. Gilabert;Daniel Bakowski;Anant B. Parekh

  • Sustained Activation of the Tyrosine Kinase Syk by Antigen in Mast Cells Requires Local Ca2+ Influx through Ca2+ Release-activated Ca2+ Channels *

    Siaw Wei Ng;Joseph di Capite;Karthika Singaravelu;Anant B. Parekh

Frequent Co-Authors

Luca Scorrano
Luca Scorrano University of Padua
Salil S. Kanhere
Salil S. Kanhere University of New South Wales
Matthew Freeman
Matthew Freeman University of Oxford
Ming Jer Tang
Ming Jer Tang National Cheng Kung University
David G. Nicholls
David G. Nicholls Buck Institute for Research on Aging
Barry V. L. Potter
Barry V. L. Potter University of Oxford
Ian J. Reynolds
Ian J. Reynolds United States Military Academy
Howard T. Jacobs
Howard T. Jacobs Tampere University
Nils-Göran Larsson
Nils-Göran Larsson Karolinska Institute
Eric A. Schon
Eric A. Schon Columbia University Medical Center

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