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Oleg Vsevolodovich Gerasimenko

Oleg Vsevolodovich Gerasimenko

D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
10226
World Ranking
17554
National Ranking
1384

Overview

Oleg Vsevolodovich Gerasimenko is affiliated with Cardiff University in the United Kingdom. Their research primarily focuses on medicine, with a significant emphasis on surgery, physiology, and molecular biology. The work spans important topics related to pancreatitis pathology and treatment, pancreatic function and diabetes, adenosine and purinergic signaling, erythrocyte function and pathophysiology, ion transport and channel regulation, calcium signaling and nucleotide metabolism, and cellular transport and secretion.

The scientist has published extensively across several journals, with a notable presence in the journal Function, where they have contributed to five papers. Other publication venues include Physiological Reviews, Cell Death and Disease, Cell Calcium, and Neuromuscular Disorders.

Recent publications include the following papers:

  • The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas (2021, Physiological Reviews)
  • Endocytic uptake of SARS-CoV-2: the critical roles of pH, Ca2+, and NAADP (2020, Function)
  • SARS-CoV-2 S Protein Subunit 1 Elicits Ca2+ Influx - Dependent Ca2+ Signals in Pancreatic Stellate Cells and Macrophages In Situ (2022, Function)
  • Activation of pancreatic stellate cells attenuates intracellular Ca2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites (2022, Cell Death and Disease)
  • Calcium Signaling in Pancreatic Immune Cells In situ (2020, Function)

Frequent co-authors in Gerasimenko's work include:

  • Julia V. Gerasimenko
  • Ole H. Petersen
  • Oleksiy Gryshchenko
  • Shuang Peng
  • Dennis T. Famili

The scientist's research extensively covers cellular and molecular mechanisms involved in pancreatic physiology and pathology, particularly the role of calcium signaling. This includes exploring calcium and ATP functions in the exocrine pancreas, the impact of SARS-CoV-2 on calcium influx in pancreatic cells, and the regulation of intracellular calcium signals related to pancreatic stellate cell activity and immune cell function.

Their work is interdisciplinary, combining elements of biochemistry, genetics, molecular biology, infectious diseases, and cell biology to address complex medical questions related to pancreatic disease and immune response.

Best Publications

  • ATP-DEPENDENT ACCUMULATION AND INOSITOL TRISPHOSPHATE- OR CYCLIC ADP-RIBOSE-MEDIATED RELEASE OF CA2+ FROM THE NUCLEAR ENVELOPE

    Oleg V Gerasimenko;Julia V Gerasimenko;Alexei V Tepikin;Ole H Petersen

  • Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca2+ signals

    Hanna Tinel;Jose M. Cancela;Hideo Mogami;Julia V. Gerasimenko

  • Galectin-3 Interaction With Thomsen-Friedenreich Disaccharide on Cancer-Associated MUC1 Causes Increased Cancer Cell Endothelial Adhesion

    Lu-Gang Yu;Nigel Andrews;Qicheng Zhao;Daniel McKean

  • Physiological Changes in Glucose Differentially Modulate the Excitability of Hypothalamic Melanin-Concentrating Hormone and Orexin Neurons In Situ

    Denis Burdakov;Oleg Vsevolodovich Gerasimenko;Alexei Verkhratsky

  • Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells.

    Dabid N. Criddle;Stuart Gillies;Heidi K. Baumgartner-Wilson;Mohammed Jaffar;Mohammed Jaffar

  • Tandem-Pore K+ Channels Mediate Inhibition of Orexin Neurons by Glucose

    Denis Burdakov;Lise T. Jensen;Haris Alexopoulos;Rhiannan H. Williams

  • Calcium uptake via endocytosis with rapid release from acidifying endosomes

    Julia V. Gerasimenko;Alexei V. Tepikin;Ole H. Petersen;Oleg V. Gerasimenko

  • Inositol Trisphosphate and Cyclic ADP-Ribose–Mediated Release of Ca2+ from Single Isolated Pancreatic Zymogen Granules

    Oleg V Gerasimenko;Julia V Gerasimenko;Pavel V Belan;Ole H Petersen

  • Calcium Elevation in Mitochondria Is the Main Ca2+ Requirement for Mitochondrial Permeability Transition Pore (mPTP) Opening

    Heidi K. Baumgartner;Julia V. Gerasimenko;Christopher Thorne;Pawel Ferdek

  • Two different but converging messenger pathways to intracellular Ca2+ release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate

    Jose Manuel Cancela;Oleg Vsevolodovich Gerasimenko;Julia Vladimirovna Gerasimenko;Alexei Tepikin

  • NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors

    Julia Vladimirovna Gerasimenko;Yoshio Maruyama;Kojiro Yano;Nick J. Dolman

  • Epithelial Barrier Function In Vivo Is Sustained Despite Gaps in Epithelial Layers

    Alastair J.M. Watson;Shaoyou Chu;Leah Sieck;Oleg Vsevolodovich Gerasimenko

  • Cyclic ADP-ribose regulation of ryanodine receptors involved in agonist evoked cytosolic Ca2+ oscillations in pancreatic acinar cells.

    P. Thorn;O. Gerasimenko;O.H. Petersen

  • Calcium signalling and pancreatic cell death: apoptosis or necrosis?

    D. N. Criddle;Julia Vladimirovna Gerasimenko;H. K. Baumgartner;M. Jaffar

  • Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells

    David Booth;David Booth;John Murphy;John Murphy;Rajarshi Mukherjee;Rajarshi Mukherjee;Muhammad Awais

  • Menadione-induced apoptosis: roles of cytosolic Ca2+elevations and the mitochondrial permeability transition pore

    Julia Vladimirovna Gerasimenko;Oleg Vsevolodovich Gerasimenko;Altaf Palejwala;Alexei Tepikin

  • Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy

    Julia Vladimirovna Gerasimenko;Oleksiy Gryshchenko;Pawel Ferdek;Eloise Stapleton

  • NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area

    Julia Vladimirovna Gerasimenko;Mark Sherwood;Alexei Tepikin;Ole Holger Petersen

  • Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells

    Mark W. Sherwood;Ian A. Prior;Svetlana G. Voronina;Stephanie L. Barrow

  • Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors.

    Julia Vladimirovna Gerasimenko;S. E. Flowerdew;S. G. Voronina;T. K. Sukhomlin

Frequent Co-Authors

Ole H. Petersen
Ole H. Petersen Cardiff University
Alexei V. Tepikin
Alexei V. Tepikin University of Liverpool
Robert Sutton
Robert Sutton University of Liverpool
Jonathan M. Rhodes
Jonathan M. Rhodes University of Liverpool
John P. Neoptolemos
John P. Neoptolemos Heidelberg University
Katsuhiko Mikoshiba
Katsuhiko Mikoshiba ShanghaiTech University
Robert D. Burgoyne
Robert D. Burgoyne University of Liverpool
Denis Burdakov
Denis Burdakov ETH Zurich
Alexei Verkhratsky
Alexei Verkhratsky University of Manchester

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