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Chemistry

D-Index
63
Citations
15714
World Ranking
8347
National Ranking
173

Biology and Biochemistry

D-Index
63
Citations
15894
World Ranking
10121
National Ranking
179

Overview

Tilman Schirmer is affiliated with the University of Basel in Switzerland. Their research primarily focuses on the fields of biochemistry, genetics, and molecular biology, with significant contributions to immunology and microbiology. Schirmer's work spans multiple subfields including molecular biology, immunology, genetics, parasitology, and endocrinology.

The main topics covered in Schirmer's research include bacterial genetics and biotechnology, bacterial biofilms and quorum sensing, Bartonella species infections research, toxin mechanisms and immunotoxins, bacteriophages and microbial interactions, immune response and inflammation, and studies related to Vibrio bacteria.

Schirmer has contributed to a number of recent publications, with notable papers including:

  • Precise timing of transcription by c-di-GMP coordinates cell cycle and morphogenesis in Caulobacter, 2020, Nature Communications
  • Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus, 2020, Nature Microbiology
  • Intercepting second-messenger signaling by rationally designed peptides sequestering c-di-GMP, 2020, Proceedings of the National Academy of Sciences
  • A Bacterial Inflammation Sensor Regulates c-di-GMP Signaling, Adhesion, and Biofilm Formation, 2021, mBio
  • Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase, 2021, Nature Communications

Frequent coauthors collaborate regularly with Schirmer, and these include:

  • Badri N. Dubey
  • Urs Jenal
  • Sebastian Hiller
  • Raphael Dias Teixeira
  • Markus Huber

Schirmer's research has been published across several venues, with frequent contributions to bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Proceedings of the National Academy of Sciences, Nature Microbiology, and mBio.

Best Publications

  • Crystal structures explain functional properties of two E. coli porins

    S. W. Cowan;T. Schirmer;G. Rummel;M. Steiert

  • Structural basis for sugar translocation through maltoporin channels at 3.1 A resolution.

    Tilman Schirmer;Thomas A. Keller;Yan-Fei Wang;Jurg P. Rosenbusch

  • Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain

    Ralf Paul;Stefan Weiser;Nicholas C. Amiot;Carmen Chan

  • Structural basis of activity and allosteric control of diguanylate cyclase

    Carmen Chan;Ralf Paul;Dietrich Samoray;Nicolas C. Amiot

  • Structural and mechanistic determinants of c-di-GMP signalling

    Tilman Schirmer;Urs Jenal

  • X-ray crystallographic structure of the light-harvesting biliprotein C-phycocyanin from the thermophilic cyanobacterium Mastigocladus laminosus and its resemblance to globin structures

    Tilman Schirmer;Wolfram Bode;Robert Huber;Walter Sidler

  • Refined three-dimensional structures of two cyanobacterial C-phycocyanins at 2.1 and 2.5 A resolution. A common principle of phycobilin-protein interaction.

    Tilman Schirmer;Wolfram Bode;Robert Huber

  • Crystal structure of hyaluronidase, a major allergen of bee venom.

    Zora Marković-Housley;Giuliana Miglierini;Lyudmila Soldatova;Pierre J. Rizkallah

  • Crystal structure analysis and refinement at 2·5 Å of hexameric C-phycocyanin from the cyanobacterium Agmenellum quadruplicatum: The molecular model and its implications for light-harvesting

    Tilman Schirmer;Robert Huber;Monika Schneider;Wolfram Bode

  • Structural basis of the allosteric behaviour of phosphofructokinase.

    Tilman Schirmer;Philip R. Evans

  • General and specific porins from bacterial outer membranes.

    Tilman Schirmer

  • Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress.

    Alex Boehm;Samuel Steiner;Franziska Zaehringer;Alain Casanova

  • Crystal structure of osmoporin OmpC from E. coli at 2.0 A

    Arnaud Baslé;Gabriele Rummel;Paola Storici;Juerg P. Rosenbusch

  • Structure of BeF3−-Modified Response Regulator PleD: Implications for Diguanylate Cyclase Activation, Catalysis, and Feedback Inhibition

    Paul Wassmann;Carmen Chan;Ralf Paul;Andreas Beck

  • The structure of OmpF porin in a tetragonal crystal form

    SW Cowan;RM Garavito;JN Jansonius;JA Jenkins

  • X-ray structure of a decameric cyclophilin-cyclosporin crystal complex

    Gaston Pflügl;Jörg Kallen;Tilman Schirmer;Johan N. Jansonius

  • Structural and Functional Characterization of OmpF Porin Mutants Selected for Larger Pore Size II. FUNCTIONAL CHARACTERIZATION

    Nathalie Saint;Kuo-Long Lou;Christine Widmer;Mary Luckey

  • Electrostatic properties of two porin channels from Escherichia coli.

    A. Karshikoff;V. Spassov;S.W. Cowan;R. Ladenstein

  • Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway.

    R Dutzler;Y.F Wang;P.J Rizkallah;J.P Rosenbusch

  • Role of charged residues at the OmpF porin channel constriction probed by mutagenesis and simulation.

    Prashant S. Phale;Ansgar Philippsen;Christine Widmer;Vrishali P. Phale

Frequent Co-Authors

Urs Jenal
Urs Jenal University of Basel
Johan N. Jansonius
Johan N. Jansonius University of Basel
Christoph Dehio
Christoph Dehio University of Basel
Wolfram Bode
Wolfram Bode Max Planck Society
Thomas R. Ward
Thomas R. Ward University of Basel
Herbert Zuber
Herbert Zuber ETH Zurich
Stephan Grzesiek
Stephan Grzesiek University of Basel
Richard B. Silverman
Richard B. Silverman Northwestern University
Ralf Koebnik
Ralf Koebnik University of Montpellier
Kenn Gerdes
Kenn Gerdes University of Copenhagen

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