World's Best Scientists 2026 revealed!
Stephan Grzesiek

Stephan Grzesiek

D-Index & Metrics

Chemistry

D-Index
77
Citations
41544
World Ranking
3919
National Ranking
92

Overview

Stephan Grzesiek is affiliated with the University of Basel in Switzerland and has an extensive research portfolio primarily in biochemistry, genetics, and molecular biology. Their work frequently intersects with medicine, with a focus on molecular biology and related subfields such as radiology, nuclear medicine and imaging, hematology, cellular and molecular neuroscience, and immunology.

The scientist's research covers a range of main topics including receptor mechanisms and signaling, monoclonal and polyclonal antibodies research, chronic myeloid leukemia treatments, protein kinase regulation and GTPase signaling, neuropeptides and animal physiology, mass spectrometry techniques and applications, and chronic lymphocytic leukemia research.

Significant recent papers authored or co-authored by Stephan Grzesiek include:

  • "Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist" (2021), published in Science Advances
  • "A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR" (2020), published in Nature Communications
  • "A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes" (2023), published in Molecular Cell
  • "Filling of a water-free void explains the allosteric regulation of the β1-adrenergic receptor by cholesterol" (2022), published in Nature Chemistry
  • "Intercepting second-messenger signaling by rationally designed peptides sequestering c-di-GMP" (2020), published in Proceedings of the National Academy of Sciences

The frequent co-authors collaborating with Grzesiek include Layara Akemi Abiko, Judith Habazettl, Anne Grahl, Ivana Petrović, and Johannes Paladini. These collaborations reflect interdisciplinary and multi-author approaches to complex biochemical and biomedical research questions.

Stephan Grzesiek's publications are distributed across various research venues with the most common being bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Proceedings of the National Academy of Sciences, eLife, and Science Advances.

The scientist's work emphasizes detailed molecular insights into receptor function and signaling pathways, often employing advanced techniques such as nuclear magnetic resonance (NMR) and mass spectrometry. Their studies contribute to understanding molecular mechanisms underlying medical conditions and help advance therapeutic research in oncology and immunology.

Best Publications

  • NMRPipe: a multidimensional spectral processing system based on UNIX pipes

    Frank Delaglio;Stephan Grzesiek;Geerten W. Vuister;Guang Zhu

  • Correlating Backbone Amide and Side-Chain Resonances in Larger Proteins By Multiple Relayed Triple Resonance NMR

    Stephan Grzesiek;Ad Bax

  • The Importance of Not Saturating H2o in Protein NMR : application to Sensitivity Enhancement and Noe Measurements

    Stephan Grzesiek;Ad Bax

  • Improved 3D triple-resonance NMR techniques applied to a 31 kDa protein

    Stephan Grzesiek;Ad Bax

  • Methodological advances in protein NMR

    Ad Bax;Stephan Grzesiek

  • Amino acid type determination in the sequential assignment procedure of uniformly 13C/15N-enriched proteins.

    Stephan Grzesiek;Ad Bax

  • Solution structure of calcium-free calmodulin.

    Hitoshi Kuboniwa;Nico Tjandra;Stephan Grzesiek;Hao Ren

  • Correlation of backbone amide and aliphatic side-chain resonances in 13C/15N-enriched proteins by isotropic mixing of 13C magnetization

    S. Grzesiek;J. Anglister;A. Bax

  • Direct Observation of Hydrogen Bonds in Nucleic Acid Base Pairs by Internucleotide 2JNN Couplings

    Andrew J. Dingley;Stephan Grzesiek

  • Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

    Jianming Zhang;Francisco J. Adrián;Wolfgang Jahnke;Sandra W. Cowan-Jacob

  • An efficient experiment for sequential backbone assignment of medium-sized isotopically enriched proteins

    Stephan Grzesiek;Ad Bax

  • Direct Observation of Hydrogen Bonds in Proteins by Interresidue 3hJNC' Scalar Couplings

    Florence Cordier;Stephan Grzesiek

  • The CD4 Determinant for Downregulation by HIV-1 Nef Directly Binds to Nef. Mapping of the Nef Binding Surface by NMR†

    Stephan Grzesiek;Stephen J. Stahl;Paul T. Wingfield;Ad Bax

  • Measurement of homo- and heteronuclear J couplings from quantitative J correlation

    Ad Bax;Geerten W Vuister;Stephan Grzesiek;Frank Delaglio

  • Solution NMR of proteins within polyacrylamide gels: diffusional properties and residual alignment by mechanical stress or embedding of oriented purple membranes.

    Hans-Jürgen Sass;Giovanna Musco;Stephen J. Stahl;Paul T. Wingfield

  • The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase.

    S. Grzesiek;A. Bax;G. M. Clore;A. M. Gronenborn

  • Measurement of HN-H alpha J couplings in calcium-free calmodulin using new 2D and 3D water-flip-back methods.

    Hitoshi Kuboniwa;Stephan Grzesiek;Frank Delaglio;Ad Bax

  • Flexibility and function in HIV-1 protease

    Nicholson Lk;Yamazaki T;Torchia Da;Grzesiek S

  • Internucleotide Scalar Couplings Across Hydrogen Bonds in Watson−Crick and Hoogsteen Base Pairs of a DNA Triplex

    Andrew J. Dingley;James E. Masse;Robert D. Peterson;Michael Barfield

  • Purple membrane induced alignment of biological macromolecules in the magnetic field

    Jürgen Sass;Florence Cordier;Astrid Hoffmann;Marco Rogowski

  • Solution Conformations and Dynamics of ABL Kinase-Inhibitor Complexes Determined by NMR Substantiate the Different Binding Modes of Imatinib/Nilotinib and Dasatinib

    Navratna Vajpai;André Strauss;Gabriele Fendrich;Sandra W. Cowan-Jacob

Frequent Co-Authors

Ad Bax
Ad Bax National Institutes of Health
Sebastian Meier
Sebastian Meier Technical University of Denmark
Geerten W. Vuister
Geerten W. Vuister University of Leicester
Martin Blackledge
Martin Blackledge Grenoble Alpes University
Stephen J. Stahl
Stephen J. Stahl National Institutes of Health
Paul T. Wingfield
Paul T. Wingfield National Institutes of Health
Wolfgang Jahnke
Wolfgang Jahnke Novartis (Switzerland)
Dennis A. Torchia
Dennis A. Torchia National Institutes of Health
Gebhard F. X. Schertler
Gebhard F. X. Schertler Paul Scherrer Institute
Urs Jenal
Urs Jenal University of Basel

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in Chemistry, exploring related fields can open diverse career opportunities. One such pathway is forensic science, which combines chemical expertise with investigative skills. If you're considering this avenue, you might want to explore the cheapest online forensic science degree programs available. These affordable options make it easier to pursue advanced education without breaking the bank.

Further specialization is also possible through degrees like an online masters degree in forensic psychology. This interdisciplinary approach merges psychology with criminal justice, complementing a strong foundation in Chemistry.

Career opportunities within forensic science are broad and evolving. From crime scene analysis to laboratory research, various roles await graduates with a scientific background. To better understand your options, take a look at forensic science careers, which offers insights into typical job paths and industry demands.

Before committing, it’s crucial to consider economics. Understanding how much is a criminal justice degree can help you budget for your education and plan your investment wisely. Balancing cost with quality ensures a rewarding academic and professional experience.

Best Scientists Citing Stephan Grzesiek

Trending Scientists

Recently Published Articles