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Chemistry

D-Index
54
Citations
10547
World Ranking
12599
National Ranking
227

Overview

Wolfgang Jahnke is affiliated with Novartis in Switzerland, contributing to the fields of biochemistry, genetics, and molecular biology. Their research encompasses a broad range of topics with a focus on molecular biology as the primary subfield, supplemented by work in organic chemistry, computational theory and mathematics, materials chemistry, and pharmaceutical science.

Their scientific interests focus on various domains, including computational drug discovery methods, protein degradation and inhibitors, click chemistry and applications, chemical reactions and isotopes, monoclonal and polyclonal antibodies research, protein structure and dynamics, and treatments related to chronic myeloid leukemia.

Jahnke has contributed to multiple publications, frequently collaborating with coauthors such as Iwan J. P. de Esch, Daniel A. Erlanson, Christopher N. Johnson, Martin Renatus, and Markus Wartmann. Their work is regularly featured in several publication venues, prominently in:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Journal of Medicinal Chemistry
  • RSC Chemical Biology
  • Journal of Biomolecular NMR
  • Nature Communications

Among recent papers featuring Wolfgang Jahnke, the following are notable:

  • Fragment-to-Lead Medicinal Chemistry Publications in 2019, published in 2020 in the Journal of Medicinal Chemistry
  • Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4, 2020, Journal of Medicinal Chemistry
  • Fragment-to-Lead Medicinal Chemistry Publications in 2018, 2020, Journal of Medicinal Chemistry
  • Fragment-to-Lead Medicinal Chemistry Publications in 2020, 2021, Journal of Medicinal Chemistry
  • Fragment-to-Lead Medicinal Chemistry Publications in 2021, 2023, Journal of Medicinal Chemistry

Best Publications

  • Twenty years on: the impact of fragments on drug discovery.

    Daniel A. Erlanson;Stephen W. Fesik;Roderick E. Hubbard;Wolfgang Jahnke

  • Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

    Jianming Zhang;Francisco J. Adrián;Wolfgang Jahnke;Sandra W. Cowan-Jacob

  • A simple protocol for amino acid type selective isotope labeling in insect cells with improved yields and high reproducibility

    Alvar D. Gossert;Alexandra Hinniger;Sascha Gutmann;Wolfgang Jahnke

  • Perspectives on NMR in drug discovery: a technique comes of age

    Maurizio Pellecchia;Ivano Bertini;David Cowburn;Claudio Dalvit

  • The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation

    Sandra W. Cowan-Jacob;Gabriele Fendrich;Paul W. Manley;Wolfgang Jahnke

  • Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.

    J. Schoepfer;W. Jahnke;G. Berellini;S. Buonamici

  • Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.

    Jean-Michel Rondeau;Francis Bitsch;Emmanuelle Bourgier;Martin Geiser

  • Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein

    Dahai Luo;Ting Xu;Randall P Watson;Daniella Scherer-Becker

  • Solution Conformations and Dynamics of ABL Kinase-Inhibitor Complexes Determined by NMR Substantiate the Different Binding Modes of Imatinib/Nilotinib and Dasatinib

    Navratna Vajpai;André Strauss;Gabriele Fendrich;Sandra W. Cowan-Jacob

  • Library Design for Fragment Based Screening

    Ansgar Schuffenhauer;Simon Ruedisser;Andreas L. Marzinzik;Wolfgang Jahnke

  • NMR in drug discovery: A practical guide to identification and validation of ligands interacting with biological macromolecules.

    Alvar D. Gossert;Wolfgang Jahnke

  • Measurement of fast proton exchange rates in isotopically labeled compounds

    Gerd Gemmecker;Wolfgang Jahnke;Horst Kessler

  • NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors

    Lukasz Skora;Jürgen Mestan;Doriano Fabbro;Wolfgang Jahnke

  • Spin label enhanced NMR screening.

    Wolfgang Jahnke;Simon Rüdisser;Mauro Zurini

  • Molecular basis of coiled-coil formation.

    Michel O. Steinmetz;Ilian Jelesarov;William M. Matousek;Srinivas Honnappa

  • Chemical shift as a probe of molecular interfaces: NMR studies of DNA binding by the three amino-terminal zinc finger domains from transcription factor IIIA

    Mark P. Foster;Deborah S. Wuttke;Karen R. Clemens;Wolfgang Jahnke

  • Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery

    Wolfgang Jahnke;Jean-Michel Rondeau;Simona Cotesta;Andreas Marzinzik

  • Op18/stathmin caps a kinked protofilament-like tubulin tetramer

    Michel O. Steinmetz;Richard A. Kammerer;Wolfgang Jahnke;Kenneth N. Goldie

  • Fragment-to-Lead Medicinal Chemistry Publications in 2020

    Unknown

  • Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay.

    Wolfgang Jahnke;Robert M. Grotzfeld;Xavier Pellé;André Strauss

  • NMR Reporter Screening for the Detection of High-Affinity Ligands

    Wolfgang Jahnke;Philipp Floersheim;Christian Ostermeier;Xiaolu Zhang

  • The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents.

    Teresa Carlomagno;Marcel J. J. Blommers;Jens Meiler;Jens Meiler;Wolfgang Jahnke

  • Solution Conformations and Dynamics of ABL Kinase-Inhibitor Complexes Determined by NMR Substantiate the Different Binding Modes of

    Navratna Vajpai;Gabriele Fendrich;Sandra W. Cowan-Jacob;Paul W. Manley

Frequent Co-Authors

Pascal Furet
Pascal Furet Novartis (Switzerland)
Stephan Grzesiek
Stephan Grzesiek University of Basel
Doriano Fabbro
Doriano Fabbro Novartis (Switzerland)
Jens Meiler
Jens Meiler Vanderbilt University
Michel O. Steinmetz
Michel O. Steinmetz Paul Scherrer Institute
Beat Ernst
Beat Ernst University of Basel
Mitsuhiko Ikura
Mitsuhiko Ikura Princess Margaret Cancer Centre
Nathanael S. Gray
Nathanael S. Gray Stanford University
Gabor Tigyi
Gabor Tigyi University of Tennessee Health Science Center
Richard A. Kammerer
Richard A. Kammerer Paul Scherrer Institute

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