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Chemistry

D-Index
54
Citations
11300
World Ranking
12542
National Ranking
226

Overview

Beat Ernst is affiliated with the University of Basel in Switzerland and has contributed extensively to the fields of biochemistry, genetics, molecular biology, medicine, and chemistry. Their work spans multiple subfields including molecular biology, organic chemistry, immunology, endocrinology, and radiology, nuclear medicine, and imaging.

The scientist's research focuses on topics such as glycosylation and glycoproteins research, carbohydrate chemistry and synthesis, monoclonal and polyclonal antibodies research, immunotherapy and immune responses, Escherichia coli research studies, antibiotic resistance in bacteria, and chemical synthesis and analysis.

Frequent coauthors in their work include Said Rabbani, Xiaohua Jiang, Oliver Schwardt, Jonathan Cramer, and Roman P. Jakob.

Beat Ernst has published multiple papers in various scientific venues. Some recent publications include:

  • Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2 (2021), Journal of the American Chemical Society
  • Antiadhesive natural products against uropathogenic E. coli: What can we learn from cranberry extract? (2020), Journal of Ethnopharmacology
  • Differential recognition of oligomannose isomers by glycan-binding proteins involved in innate and adaptive immunity (2021), Science Advances
  • A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN (2021), Journal of the American Chemical Society
  • Selective inhibition of anti-MAG IgM autoantibody binding to myelin by an antigen-specific glycopolymer (2020), Journal of Neurochemistry

Research by Beat Ernst has appeared frequently in the following publication venues:

  • ChemMedChem
  • European Journal of Medicinal Chemistry
  • Journal of the American Chemical Society
  • Journal of Medicinal Chemistry
  • Molecules

Their contributions cover a broad interdisciplinary spectrum with connections among molecular biology, synthetic organic chemistry, and immunological studies, reflecting an emphasis on both fundamental biochemical processes and applied medicinal research.

Best Publications

  • From carbohydrate leads to glycomimetic drugs

    Beat Ernst;John L. Magnani

  • Carbohydrates in chemistry and biology

    Beat Ernst;Gerald Warren Hart;Pierre Sinay

  • Cyclobutanones and Cyclobutenones in Nature and in Synthesis [New Synthetic Methods(71)]

    Daniel Belluš;Beat Ernst

  • GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice.

    Jungshan Chang;John T. Patton;Arun Sarkar;Beat Ernst

  • Oligohis-tags: mechanisms of binding to Ni2+-NTA surfaces.

    Steven Knecht;Daniel Ricklin;Alex N. Eberle;Beat Ernst

  • Catch-bond mechanism of the bacterial adhesin FimH

    Maximilian M. Sauer;Roman P. Jakob;Jonathan Eras;Sefer Baday;Sefer Baday

  • FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation.

    Tobias Klein;Daniela Abgottspon;Matthias Wittwer;Said R. Rabbani

  • Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor.

    Oleg Khorev;Daniela Stokmaier;Oliver Schwardt;Brian Cutting

  • Hydroxyl Groups in Synthetic and Natural-Product-Derived Therapeutics: A Perspective on a Common Functional Group.

    Jonathan Cramer;Christoph P Sager;Beat Ernst

  • Peripheral lipopolysaccharide administration transiently affects expression of brain-derived neurotrophic factor, corticotropin and proopiomelanocortin in mouse brain.

    Sabine Schnydrig;Lukas Korner;Svenja Landweer;Beat Ernst

  • Systemic administration of a TLR7 ligand leads to transient immune incompetence due to peripheral blood leukocyte depletion

    Matthias Gunzer;Helge Riemann;Yasmin Basoglu;Anja Hillmer

  • Antiadhesion therapy for urinary tract infections--a balanced PK/PD profile proved to be key for success

    Xiaohua Jiang;Daniela Abgottspon;Simon Kleeb;Said Rabbani

  • DEVELOPMENT OF TOOLS FOR THE DESIGN OF SELECTIN ANTAGONISTS

    Hartmuth C. Kolb;Beat Ernst

  • EUROCarbDB: An open-access platform for glycoinformatics

    Claus Wilhelm Von Der Lieth;Ana Ardá Freire;Dennis Blank;Matthew P. Campbell;Matthew P. Campbell

  • Determination of the Bioactive Conformation of the Carbohydrate Ligand in the E‐Selectin/Sialyl LewisX Complex

    Thomas Peters;Karoline Scheffler;Beat Ernst;Andreas Katopodis

  • Intramolecular [2+2] cycloadditions of ketenes and keteniminium salts to olefins

    Istvan Marko;Bruno Ronsmans;Anne Marie Hesbain-Frisque;Stephane Dumas

  • A safe and convenient method for the preparation of triflyl azide, and its use in diazo transfer reactions to primary amines

    Alexander Titz;Zorana Radic;Oliver Schwardt;Beat Ernst

  • Dynamic Combinatorial Chemistry: A New Methodology Comes of Age

    Priska Frei;Rachel Hevey;Beat Ernst

  • Extraction and analysis of intact glucosinolates – A validated pressurized liquid extraction/liquid chromatography-mass spectrometry protocol for Isatis tinctoria, and qualitative analysis of other cruciferous plants

    Tobias Mohn;Brian Cutting;Beat Ernst;Matthias Hamburger

  • Fimh Antagonists: Bioisosteres to Improve the in Vitro and in Vivo Pk/Pd Profile.

    Simon Kleeb;Lijuan Pang;Katharina Mayer;Deniz Eriş

  • Drug discovery today.

    Oliver Schwardt;Hartmuth Kolb;Beat Ernst

Frequent Co-Authors

Gerald W. Hart
Gerald W. Hart University of Georgia
Pierre Sinaÿ
Pierre Sinaÿ École Normale Supérieure
Wolfgang Jahnke
Wolfgang Jahnke Novartis (Switzerland)
Daniel Ricklin
Daniel Ricklin University of Basel
Monica M. Palcic
Monica M. Palcic Carlsberg Laboratory
Paul S. Frenette
Paul S. Frenette Albert Einstein College of Medicine
Ole Hindsgaul
Ole Hindsgaul University of Alberta
Hartmuth C. Kolb
Hartmuth C. Kolb Janssen (Belgium)
Stephen Hanessian
Stephen Hanessian University of Montreal

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