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Hartmuth C. Kolb

Hartmuth C. Kolb

D-Index & Metrics

Chemistry

D-Index
50
Citations
38070
World Ranking
14210
National Ranking
173

Overview

Hartmuth C. Kolb is affiliated with Janssen in Belgium and has a research focus primarily within the field of Medicine. Their work spans multiple subfields, including Physiology, Psychiatry and Mental Health, Molecular Biology, Cognitive Neuroscience, and Neurology.

The scientist has contributed extensively to studies related to Alzheimer's disease and dementia, as well as other topics such as functional brain connectivity, S100 proteins and annexins, medical imaging techniques, neuroinflammation, neurodegeneration mechanisms, and epilepsy research and treatment.

Among the recent publications coauthored by Hartmuth C. Kolb are:

  • Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease (2022, Brain)
  • Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease (2020, Nature Communications)
  • Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease (2023, Nature Medicine)
  • Association of Phosphorylated Tau Biomarkers With Amyloid Positron Emission Tomography vs Tau Positron Emission Tomography (2022, JAMA Neurology)
  • Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays (2022, Alzheimer s & Dementia)

Frequent collaborators include:

  • Gallen Triana-Baltzer
  • Kaj Blennow
  • Nicholas J. Ashton
  • Pedro Rosa-Neto
  • Thomas K. Karikari

Hartmuth C. Kolb has published in a range of venues, most notably:

  • Alzheimer s & Dementia (42 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (9 publications)
  • Brain (3 publications)
  • JAMA Neurology (3 publications)
  • The Journal of Prevention of Alzheimer s Disease (3 publications)

Their research work centers extensively on Alzheimer's disease research and treatments as well as dementia and cognitive impairment research. The scope of topics covered includes detailed investigations into biomarkers, neurodegenerative processes, and the physiological underpinnings relevant to these fields.

Best Publications

  • Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

    Hartmuth C. Kolb;M. G. Finn;K. Barry Sharpless

  • Catalytic Asymmetric Dihydroxylation

    Hartmuth C. Kolb;Michael S. VanNieuwenhze;K. Barry Sharpless

  • The growing impact of click chemistry on drug discovery.

    Hartmuth C Kolb;K.Barry Sharpless

  • “On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension

    Sridhar Narayan;John Muldoon;M. G. Finn;Valery V. Fokin

  • Click-Chemie: diverse chemische Funktionalität mit einer Handvoll guter Reaktionen

    Hartmuth C. Kolb;M. G. Finn;K. Barry Sharpless

  • Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics.

    Chung-Cheng Lee;Guodong Sui;Arkadij Elizarov;Chengyi Jenny Shu

  • Inhibitors of HIV‐1 Protease by Using In Situ Click Chemistry

    Matthew Whiting;John Muldoon;Ying-Chuan Lin;Steven M. Silverman

  • [18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

    Chun-Fang Xia;Janna Arteaga;Gang Chen;Umesh Gangadharmath

  • In situ click chemistry: enzyme inhibitors made to their own specifications.

    Roman Manetsch;Antoni Krasiński;Zoran Radić;Jessica Raushel

  • In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors.

    Antoni Krasiński;Zoran Radić;Roman Manetsch;Jessica Raushel

  • The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities.

    Joseph C. Walsh;Artem Lebedev;Edward Aten;Kathleen Madsen

  • Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation.

    Yves Bourne;Hartmuth C. Kolb;Zoran Radić;K. Barry Sharpless

  • A simplified procedure for the stereospecific transformation of 1,2-diols into epoxides

    Hartmuth C. Kolb;K.Barry Sharpless

  • Toward an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation (AD). 1. Kinetics

    Hartmuth C. Kolb;Pher G. Andersson;K. Barry Sharpless

  • Improved enantioselectivity in asymmetric dihydroxylations of terminal olefins using pyrimidine ligands

    Gerard A. Crispino;Kyu Sung Jeong;Hartmuth C. Kolb;Zhi Min Wang

  • In Situ Click Chemistry: Enzyme-Generated Inhibitors of Carbonic Anhydrase II

    Vani P. Mocharla;Benoit Colasson;Lac V. Lee;Stefanie Röper

  • A Highly Selective and Specific PET Tracer for Imaging of Tau Pathologies

    Wei Zhang;Janna Arteaga;Daniel K. Cashion;Gang Chen

  • Microfluidic devices with chemical reaction circuits

    Chung-Cheng Lee;Guodong Sui;Arkadij Elizarov;Hartmuth C. Kolb

  • Integrated microfluidics for parallel screening of an in situ click chemistry library

    Jinyi Wang;Guodong Sui;Vani P. Mocharla;Rachel J. Lin

  • Detection of HER2-Positive Metastases in Patients with HER2-Negative Primary Breast Cancer Using 89Zr-Trastuzumab PET/CT

    Gary A. Ulaner;David M. Hyman;Dara S. Ross;Adriana Corben

  • Large-scale and highly enantioselective synthesis of the taxol C-13 side chain through asymmetric dihydroxylation

    Zhi-Min Wang;Hartmuth C. Kolb;K. Barry Sharpless

  • Drug discovery today.

    Oliver Schwardt;Hartmuth Kolb;Beat Ernst

Frequent Co-Authors

K. Barry Sharpless
K. Barry Sharpless Scripps Research Institute
James R. Heath
James R. Heath California Institute of Technology
Sebastiaan Engelborghs
Sebastiaan Engelborghs Vrije Universiteit Brussel
M. G. Finn
M. G. Finn Georgia Institute of Technology
Kaj Blennow
Kaj Blennow University of Gothenburg
Henrik Zetterberg
Henrik Zetterberg University of Gothenburg
Palmer Taylor
Palmer Taylor University of California, San Diego
Diederik Moechars
Diederik Moechars Janssen (Belgium)
Maura L. Furey
Maura L. Furey Janssen (Belgium)
Hsian-Rong Tseng
Hsian-Rong Tseng University of California, Los Angeles

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