Diederik Moechars

Best Publications

• A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.

  Hannah Van Hove;Liesbet Martens;Isabelle Scheyltjens;Karen De Vlaminck

  1035
  Citations

• Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

  Dieder Moechars;Ilse Dewachter;Kristin Lorent;Delphine Reversé

  896
  Citations

• Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.

  J Chapuis;F Hansmannel;M Gistelinck;A Mounier

  470
  Citations

• Requirement of central ghrelin signaling for alcohol reward

  Elisabet Jerlhag;Emil Egecioglu;Sara Landgren;Nicolas Salomé

  467
  Citations

• Tau association with synaptic vesicles causes presynaptic dysfunction

  Lujia Zhou;Joseph McInnes;Keimpe Wierda;Matthew Holt

  441
  Citations

• LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis

  Samer Matta;Kristof Van Kolen;Raquel da Cunha;Geert van den Bogaart;Geert van den Bogaart

  418
  Citations

• Glycogen Synthase Kinase-3β Phosphorylates Protein Tau and Rescues the Axonopathy in the Central Nervous System of Human Four-repeat Tau Transgenic Mice

  Kurt Spittaels;Chris Van Den Haute;Jo Van Dorpe;Hugo Geerts

  394
  Citations

• Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice

  Ilse Dewachter;Delphine Reversé;Nathalie Caluwaerts;Laurence Ris

  388
  Citations

• Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins

  Bart De Strooper;Monique Beullens;Bart Contreras;Lyne Levesque

  372
  Citations

• Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice

  Ina Tesseur;Jo Van Dorpe;K Spittaels;Chris Van Den Haute

  301
  Citations

• Response to Comment on “Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake”

  Jian V. Zhang;Cynthia Klein;Pei-Gen Ren;Stefan Kass

  280
  Citations

• Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

  Sara Calafate;Sara Calafate;Arjan Buist;Katarzyna Miskiewicz;Vinoy Vijayan

  276
  Citations

• Loss of Bin1 Promotes the Propagation of Tau Pathology

  Sara Calafate;Sara Calafate;William Flavin;Patrik Verstreken;Diederik Moechars

  273
  Citations

• Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

  D. Moechars;K. Lorent;B. De Strooper;I. Dewachter

  261
  Citations

• Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain.

  Diederik Moechars;Matthew C. Weston;Sandra Leo;Zsuzsanna Callaerts-Vegh

  256
  Citations

• Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein

  K. Lorent;L. Overbergh;D. Moechars;B. de Strooper

  244
  Citations

• Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

  Eve Peeraer;Astrid Bottelbergs;Kristof Van Kolen;Ilie-Cosmin Stancu

  232
  Citations

• Abnormal glutamate transport function in mutant amyloid precursor protein transgenic mice.

  Eliezer Masliah;Michael Alford;Margaret Mallory;Edward Rockenstein

  197
  Citations

• Mutant Presenilins Disturb Neuronal Calcium Homeostasis in the Brain of Transgenic Mice, Decreasing the Threshold for Excitotoxicity and Facilitating Long-term Potentiation

  Ilka Schneider;Delphine Reversé;Ilse Dewachter;Laurence Ris

  192
  Citations

• Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

  Bruno Barbosa de Vasconcelos;Ilie-Cosmin Stancu;Arjan Buist;Matthew Bird

  187
  Citations

• The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Protease in Vivo

  Lujia Zhou;Soraia Barão Lourenco Barao;Mathias Laga;Katrijn Bockstael

  172
  Citations

• BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

  Soraia Barão Lourenco Barao;Diederik Moechars;Stefan F Lichtenthaler;Stefan F Lichtenthaler;Bart De Strooper;Bart De Strooper

  169
  Citations