World's Best Scientists 2026 revealed!
Patrik Verstreken

Patrik Verstreken

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
28103
World Ranking
6509
National Ranking
112

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Patrik Verstreken is affiliated with KU Leuven in Belgium and specializes in research at the intersection of biochemistry, genetics, molecular biology, medicine, and neuroscience. Their work spans 66 publications in Biochemistry, Genetics and Molecular Biology, 47 in Medicine, and 35 in Neuroscience. Subfields of study include Molecular Biology, Cellular and Molecular Neuroscience, Cell Biology, Physiology, and Neurology, reflecting a broad and interdisciplinary approach to understanding cellular processes and neurological diseases.

The research topics that Patrik Verstreken focuses on include:

  • Cellular transport and secretion
  • Alzheimer's disease research and treatments
  • Autophagy in Disease and Therapy
  • Neuroscience and Neuropharmacology Research
  • Parkinson's Disease Mechanisms and Treatments
  • Cholinesterase and Neurodegenerative Diseases
  • CRISPR and Genetic Engineering

Patrik Verstreken has published extensively with frequent appearances in notable venues such as bioRxiv (Cold Spring Harbor Laboratory) with 17 publications, Alzheimer's & Dementia with 7, Neuron with 5, The EMBO Journal with 3, and eLife with 3. This distribution underscores their engagement with both preprint platforms and peer-reviewed journals relevant to neurodegenerative disease research and molecular neuroscience.

Recent significant papers include:

  • A reference human induced pluripotent stem cell line for large-scale collaborative studies, 2022, published in Cell Stem Cell
  • Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation, 2021, published in Neuron
  • Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation, 2021, published in Acta Neuropathologica
  • The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects, 2022, published in Acta Neuropathologica Communications
  • Neuronal identity defines α-synuclein and tau toxicity, 2023, published in Neuron

Collaboration is an important aspect of Verstreken's research, with frequent co-authors including Jef Swerts (19 publications), Sabine Kuenen (16), Nils Schoovaerts (15), Carles Calatayud (12), and Sandra F. Gallego (11). This network indicates active partnerships within their research community, contributing to multidisciplinary studies and knowledge exchange.

Patrik Verstreken is a recognized member of the European Molecular Biology Organization (EMBO), highlighting affiliation with a scientific community dedicated to advancing molecular biology research.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions.

    Patrik Verstreken;Patrik Verstreken;Cindy V. Ly;Koen J.T. Venken;Tong Wey Koh

  • A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

    Kristofer Davie;Jasper Janssens;Duygu Koldere;Maxime De Waegeneer

  • Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress.

    Yakov Pesah;Tuan Pham;Heather Burgess;Brooke Middlebrooks

  • Synaptojanin Is Recruited by Endophilin to Promote Synaptic Vesicle Uncoating

    Patrik Verstreken;Tong Wey Koh;Karen L. Schulze;R. Grace Zhai

  • Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

    Vanessa Morais;Patrik Verstreken;Anne Roethig;Joel Smet

  • LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis

    Samer Matta;Kristof Van Kolen;Raquel da Cunha;Geert van den Bogaart;Geert van den Bogaart

  • Vitamin K2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency

    Melissa Vos;Giovanni Esposito;Janaka N. Edirisinghe;Sven Vilain

  • PINK1 Loss of Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

    Vanessa A. Morais;Dominik Haddad;Katleen Craessaerts;Pieter-Jan De Bock

  • Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila.

    Madhuri Kango-Singh;Riitta Nolo;Chunyao Tao;Patrik Verstreken

  • Endophilin Mutations Block Clathrin-Mediated Endocytosis but Not Neurotransmitter Release

    Patrik Verstreken;Ole Kjaerulff;Thomas E. Lloyd;Richard Atkinson

  • The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila.

    P. Robin Hiesinger;Amir Fayyazuddin;Sunil Q. Mehta;Tanja Rosenmund

  • The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

    Tom Cornelissen;Dominik Haddad;Fieke Wauters;Cindy Van Humbeeck

  • Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

    Claire L. Simpson;Robin Lemmens;Robin Lemmens;Katarzyna Miskiewicz;Katarzyna Miskiewicz;Wendy J. Broom

  • Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease

    Melissa Vos;Elsa Lauwers;Patrik Verstreken

  • Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis.

    Tong-Wey Koh;Patrik Verstreken;Hugo J Bellen;Hugo J Bellen

  • Drosophila Fragile X Protein, DFXR, Regulates Neuronal Morphology and Function in the Brain

    Joannella Morales;P.Robin Hiesinger;Andrew J. Schroeder;Kazuhiko Kume

  • Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

    Sara Calafate;Sara Calafate;Arjan Buist;Katarzyna Miskiewicz;Vinoy Vijayan

  • Mitochondria at the Synapse

    Cindy V Ly;Patrik Verstreken

  • A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals

    Sandra-Fausia Soukup;Sabine Kuenen;Roeland Vanhauwaert;Julia Manetsberger

Frequent Co-Authors

Hugo J. Bellen
Hugo J. Bellen Baylor College of Medicine
Kris Gevaert
Kris Gevaert Ghent University
Christine Klein
Christine Klein University of Lübeck
Joris de Wit
Joris de Wit KU Leuven
Diederik Moechars
Diederik Moechars Janssen (Belgium)
Frederic A. Meunier
Frederic A. Meunier University of Queensland
Bruno van Swinderen
Bruno van Swinderen University of Queensland

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