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Joris de Wit

Joris de Wit

D-Index & Metrics

Neuroscience

D-Index
37
Citations
6308
World Ranking
8756
National Ranking
105

Overview

Joris de Wit is affiliated with KU Leuven in Belgium and has a significant publication record primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Neuroscience. Their research intersects various subfields including Molecular Biology, Cellular and Molecular Neuroscience, Cell Biology, Physiology, and Neurology.

The scientist's work covers an array of topics, notably Neuroscience and Neuropharmacology Research, Cellular Transport and Secretion, Alzheimer's Disease Research and Treatments, Single-cell and Spatial Transcriptomics, Neuroscience and Neural Engineering, Neuroinflammation and Neurodegeneration Mechanisms, as well as CRISPR and Genetic Engineering.

Frequent publication venues for their research include bioRxiv (Cold Spring Harbor Laboratory) with 12 papers, Nature Communications with 3 publications, Alzheimer's & Dementia also with 3, Neuron with 2, and eLife with 2 papers.

The list of recent papers by Joris de Wit includes the following:

  • Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation, 2021, Neuron
  • Hydrop enables droplet-based single-cell ATAC-seq and single-cell RNA-seq using dissolvable hydrogel beads, 2022, eLife
  • Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer, 2020, Nature Communications
  • Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease, 2023, Nature Neuroscience
  • Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function, 2021, Cell Reports

Joris de Wit has collaborated frequently with several researchers, including Keimpe Wierda, Kristel M. Vennekens, Elke Leysen, Gabriele Marcassa, and Suresh Poovathingal, each contributing to multiple joint publications.

Best Publications

  • Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression.

    Amelia J Eisch;Carlos A Bolaños;Joris de Wit;Ryan D Simonak

  • Tau association with synaptic vesicles causes presynaptic dysfunction

    Lujia Zhou;Joseph McInnes;Keimpe Wierda;Matthew Holt

  • LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation

    Joris de Wit;Emily Sylwestrak;Matthew L. O'Sullivan;Stefanie Otto

  • Specification of synaptic connectivity by cell surface interactions

    Joris de Wit;Anirvan Ghosh

  • Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS.

    R.J. Pasterkamp;R.J. Giger;M.J. Ruitenberg;A.J.G.D. Holtmaat

  • FLRT Proteins Are Endogenous Latrophilin Ligands and Regulate Excitatory Synapse Development

    Matthew L. O'Sullivan;Joris de Wit;Jeffrey N. Savas;Davide Comoletti

  • Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

    Sara Calafate;Sara Calafate;Arjan Buist;Katarzyna Miskiewicz;Vinoy Vijayan

  • Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission.

    Heather C. Rice;Heather C. Rice;Daniel de Malmazet;Daniel de Malmazet;An Schreurs;Samuel Frere

  • Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.

    Joseph McInnes;Joseph McInnes;Keimpe Wierda;Keimpe Wierda;An Snellinx;An Snellinx;Laura Bounti;Laura Bounti

  • A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

    Sofie Voet;Conor Mc Guire;Nora Hagemeyer;Arne Martens

  • Molecular Mechanisms of Synaptic Specificity in Developing Neural Circuits

    Megan E. Williams;Joris de Wit;Anirvan Ghosh

  • Role of leucine-rich repeat proteins in the development and function of neural circuits.

    Joris de Wit;Weizhe Hong;Liqun Luo;Anirvan Ghosh

  • Unbiased Discovery of Glypican as a Receptor for LRRTM4 in Regulating Excitatory Synapse Development

    Joris de Wit;Joris de Wit;Matthew L. O’Sullivan;Jeffrey N. Savas;Giuseppe Condomitti

  • Role of semaphorins in the adult nervous system

    Joris de Wit;Joost Verhaagen

  • Semaphorin 3A displays a punctate distribution on the surface of neuronal cells and interacts with proteoglycans in the extracellular matrix.

    Joris De Wit;Fred De Winter;Jan Klooster;Joost Verhaagen

  • Transient downregulation of sema3a mrna in a rat model for temporal lobe epilepsy: A novel molecular event potentially contributing to mossy fiber sprouting

    Anthony J G D Holtmaat;Jan A Gorter;Joris De Wit;Else A Tolner

  • Heparan Sulfate Proteoglycans as Emerging Players in Synaptic Specificity.

    Giuseppe Condomitti;Joris de Wit

  • PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission

    Ji Seung Ko;Gopal Pramanik;Gopal Pramanik;Ji Won Um;Ji Seon Shim

  • Control of neural circuit formation by leucine-rich repeat proteins

    Joris de Wit;Anirvan Ghosh

  • The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors

    Jeffrey N. Savas;Jeffrey N. Savas;Luís F. Ribeiro;Keimpe D. Wierda;Rebecca Wright

Frequent Co-Authors

Anirvan Ghosh
Anirvan Ghosh Unity Biotechnology
Joost Verhaagen
Joost Verhaagen Netherlands Institute for Neuroscience
Tara L. Spires-Jones
Tara L. Spires-Jones University of Edinburgh
Kirill A. Martemyanov
Kirill A. Martemyanov Scripps Research Institute
Franck Polleux
Franck Polleux Columbia University
Hyun Kim
Hyun Kim Korea University
Attila Losonczy
Attila Losonczy Columbia University
Eero Castrén
Eero Castrén University of Helsinki
Diederik Moechars
Diederik Moechars Janssen (Belgium)

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