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Biology and Biochemistry

D-Index
49
Citations
10429
World Ranking
17943
National Ranking
798

Overview

Fabrice Gouilleux is affiliated with François Rabelais University in France. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on subfields such as Hematology, Molecular Biology, Oncology, Genetics, and Materials Chemistry.

Their scientific contributions encompass several key topics, including Acute Myeloid Leukemia Research, Chronic Myeloid Leukemia Treatments, Cytokine Signaling Pathways and Interactions, Chronic Lymphocytic Leukemia Research, Synthesis and Biological Activity, Histone Deacetylase Inhibitors Research, and Protein Degradation and Inhibitors.

Fabrice Gouilleux has authored multiple publications in notable venues. Frequent journals and publication platforms include:

  • Cancers
  • Molecules
  • The Cambridge Structural Database
  • Current Medicinal Chemistry
  • Antioxidants

The scientist's recent publications highlight a focus on cancer biology and therapeutic strategies. Selected papers include:

  • Pharmacological Inhibition of Oncogenic STAT3 and STAT5 Signaling in Hematopoietic Cancers, 2020, Cancers
  • Targeted Therapeutic Strategies for the Treatment of Cancer, 2024, Cancers
  • Repurposing of Acriflavine to Target Chronic Myeloid Leukemia Treatment, 2020, Current Medicinal Chemistry
  • New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation, 2021, Molecules
  • Characterization of NADPH Oxidase Expression and Activity in Acute Myeloid Leukemia Cell Lines: A Correlation with the Differentiation Status, 2021, Antioxidants

Collaboration plays a significant role in their research output. Frequent co-authors include:

  • Marie Brachet-Botineau
  • Frédéric Mazurier
  • Kazem Zibara
  • Marie-Claude Viaud-Massuard
  • Gildas Prié

Best Publications

  • Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response

    H Wakao;F Gouilleux;B Groner

  • Functional interactions between Stat5 and the glucocorticoid receptor

    Elisabeth Stöcklin;Manuela Wissler;Fabrice Gouilleux;Bernd Groner

  • Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

    F. Gouilleux;H. Wakao;M. Mundt;B. Groner

  • Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue

    Xiuwen Liu;Gertraud W. Robinson;Fabrice Gouilleux;Bernd Groner

  • Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity

    F Gouilleux;C Pallard;I Dusanter-Fourt;H Wakao

  • STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

    Valerie Gouilleux-Gruart;Fabrice Gouilleux;Corinne Desaint;Jean-Francois Claisse

  • Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

    R Moriggl;V Gouilleux-Gruart;R Jähne;S Berchtold

  • Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.

    S Gobert;S Chretien;F Gouilleux;O Muller

  • Thrombopoietin activates a STAT5-like factor in hematopoietic cells.

    C Pallard;F Gouilleux;L Bénit;L Cocault

  • IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes

    Jens Wehinger;Fabrice Gouilleux;Bernd Groner;Juergen Finke

  • Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission

    H Fujii;Y Nakagawa;U Schindler;A Kawahara

  • IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line

    S Dumon;S Constantino Rosa Santos;F Debierre-Grockiego;V Gouilleux-Gruart

  • Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/stat 5

    Timothy J.J. Wood;Daniel Sliva;Peter E. Lobie;Tony J. Pircher

  • A Sequence of the CIS Gene Promoter Interacts Preferentially with Two Associated STAT5A Dimers: a Distinct Biochemical Difference between STAT5A and STAT5B

    Frédérique Verdier;Raquel Rabionet;Fabrice Gouilleux;Christian Beisenherz-Huss

  • Prolactin-mediated gene activation in mammary epithelial cells.

    Bernd Groner;Fabrice Gouilleux

  • Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells.

    Virginie Lacronique;Anthony Boureux;Anthony Boureux;Richard Monni;Richard Monni;Stephanie Dumon;Stephanie Dumon

  • Differential activation of Stat3 and Stat5 by distinct regions of the growth hormone receptor.

    Athanassia Sotiropoulos;Soraya Moutoussamy;Frangoise Renaudie;Mat-tine Clauss

  • Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells

    R. Moriggl;S. Berchtold;K. Friedrich;G. J. R. Standke

  • Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias.

    Noria Harir;Christian Pecquet;Marc Kerenyi;Karoline Sonneck

  • O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies

    P Freund;M A Kerenyi;M Hager;T Wagner

Frequent Co-Authors

Richard Moriggl
Richard Moriggl University of Veterinary Medicine Vienna
Sylvie Gisselbrecht
Sylvie Gisselbrecht Grenoble Alpes University
Bernd Groner
Bernd Groner Goethe University Frankfurt
Peter Valent
Peter Valent Medical University of Vienna
Veronika Sexl
Veronika Sexl University of Innsbruck
Hartmut Beug
Hartmut Beug Research Institute of Molecular Pathology
Jacques Ghysdael
Jacques Ghysdael Centre national de la recherche scientifique, CNRS
Jack-Michel Renoir
Jack-Michel Renoir Institut Gustave Roussy
Lothar Hennighausen
Lothar Hennighausen National Institutes of Health

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