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Molecular Biology

D-Index
60
Citations
12341
World Ranking
1967
National Ranking
66

Overview

Jacques Ghysdael is affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a substantial focus on subfields such as Public Health, Environmental and Occupational Health, Immunology, Molecular Biology, Hematology, and Pathology and Forensic Medicine.

Their recent published works demonstrate a continued interest in hematological malignancies and immune system interactions. Notable papers include:

  • "AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia" (2021, Cancer Discovery)
  • "Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup" (2021, Science Translational Medicine)
  • "Harnessing the MYB-dependent TAL1 5'super-enhancer for targeted therapy in T-ALL" (2023, Molecular Cancer)
  • "Targeting the TNF/IAP pathway synergizes with anti-CD3 immunotherapy in T-cell acute lymphoblastic leukemia" (2024, Blood)
  • "Preclinical efficacy of humanized, non-FcγR-binding anti-CD3 antibodies in T-cell acute lymphoblastic leukemia" (2020, Blood)

Ghysdael's work is frequently published in journals such as Blood, Cancer Discovery, Science Translational Medicine, Molecular Cancer, and PLoS ONE, indicating a consistent engagement with high-impact immunology and oncology publications.

Frequent collaborators include Christine Tran Quang, Vahid Asnafi, Hervé Dombret, Guillaume P. Andrieu, and Mehdi Latiri. These coauthors have contributed multiple papers together, reflecting continued partnerships in related research areas.

Their main research topics cover:

  • Acute Lymphoblastic Leukemia research
  • Immune Cell Function and Interaction
  • Chronic Myeloid Leukemia Treatments
  • Lymphoma Diagnosis and Treatment
  • Phagocytosis and Immune Regulation
  • Immune cells in cancer
  • Epigenetics and DNA Methylation

Jacques Ghysdael's contributions reflect a concentrated expertise in leukemia and lymphoid malignancies, particularly acute lymphoblastic leukemia, with specific attention to immune regulatory mechanisms and targeted therapies. Their research also explores epigenetic modifications relevant to therapy responsiveness, immune cell dynamics, and molecular pathways that underlie malignancy progression and treatment resistance.

Best Publications

  • The c-erb-A protein is a high-affinity receptor for thyroid hormone

    Jan Sap;Alberto Muñoz;Klaus Damm;Yves Goldberg

  • A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia

    Virginie Lacronique;Virginie Lacronique;Anthony Boureux;Anthony Boureux;Véronique Della Valle;Véronique Della Valle;Hélène Poirel;Hélène Poirel

  • Combinatorial generation of variable fusion proteins in the Ewing family of tumours.

    J Zucman;T Melot;C Desmaze;J Ghysdael

  • DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma.

    R A Bailly;R Bosselut;J Zucman;F Cormier

  • Cooperative binding of Ets-1 and core binding factor to DNA.

    David Wotton;Jacques Ghysdael;Shuwen Wang;Nancy A Speck

  • A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.

    Christine Jousset;Clémence Carron;Anthony Boureux;Christine Tran Quang

  • A 43-kDa protein related to c-Erb A alpha 1 is located in the mitochondrial matrix of rat liver.

    Chantal Wrutniak;Isabelle Cassar-Malek;Sophie Marchal;Anne Rascle

  • Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1.

    A Gégonne;R Bosselut;R A Bailly;J Ghysdael

  • TEL is a sequence-specific transcriptional repressor.

    Rodolphe G. Lopez;Clémence Carron;Cécile Oury;Paola Gardellin

  • Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice

    Alexis Dumortier;Robin Jeannet;Peggy Kirstetter;Eva Kleinmann

  • Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia

    Hind Medyouf;Hélène Alcalde;Hélène Alcalde;Caroline Berthier;Marie Claude Guillemin

  • Proteins of the ETS family with transcriptional repressor activity.

    George Mavrothalassitis;Jacques Ghysdael

  • Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes

    Sophie Deveaux;Anne Filipe;Valérie Lemarchandel;Jacques Ghysdael

  • CXCR4 Is Required for Leukemia-Initiating Cell Activity in T Cell Acute Lymphoblastic Leukemia.

    Diana Passaro;Diana Passaro;Diana Passaro;Marta Irigoyen;Marta Irigoyen;Marta Irigoyen;Claire Catherinet;Claire Catherinet;Claire Catherinet;Stéphanie Gachet;Stéphanie Gachet;Stéphanie Gachet

  • TEL-JAK2 transgenic mice develop T-cell leukemia.

    Clémence Carron;Françoise Cormier;Françoise Cormier;Anne Janin;Anne Janin;Virginie Lacronique;Virginie Lacronique

  • Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cells.

    Virginie Lacronique;Anthony Boureux;Anthony Boureux;Richard Monni;Richard Monni;Stephanie Dumon;Stephanie Dumon

  • The calcineurin/NFAT signaling pathway: A NOVEL therapeutic target in leukemia and solid tumors

    Hind Medyouf;Jacques Ghysdael

  • RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

    Susannah L Hewitt;Bu Yin;Yanhong Ji;Julie Chaumeil

  • Bovine leukemia virus involvement in enzootic bovine leukosis.

    Burny A;Bex F;Chantrenne H;Cleuter Y

  • Identification of nucleotide preferences in DNA sequences recognised specifically by c-Ets-1 protein

    Douglas B. Woods;Jacques Ghysdael;Michael J. Owen

Frequent Co-Authors

Arsène Burny
Arsène Burny Université Libre de Bruxelles
Richard Kettmann
Richard Kettmann University of Liège
Olivier Bernard
Olivier Bernard University of Paris-Saclay
Daniel Portetelle
Daniel Portetelle University of Liège
Roland Berger
Roland Berger Necker-Enfants Malades Hospital
Carine Van Lint
Carine Van Lint Université Libre de Bruxelles
Hartmut Beug
Hartmut Beug Research Institute of Molecular Pathology
Anne Janin
Anne Janin Université Paris Cité
Eric Verdin
Eric Verdin Buck Institute for Research on Aging
Philippe Kastner
Philippe Kastner Institute of Genetics and Molecular and Cellular Biology

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