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Biology and Biochemistry

D-Index
46
Citations
10882
World Ranking
18852
National Ranking
877

Overview

Susan Chan is affiliated with the Institute of Genetics and Molecular and Cellular Biology in France. Their work focuses primarily on the fields of Medicine and Immunology and Microbiology, with a significant emphasis on Immunology as a subfield.

Their research spans several interconnected topics, including:

  • Immune Cell Function and Interaction
  • Acute Lymphoblastic Leukemia research
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Chronic Lymphocytic Leukemia Research
  • Childhood Cancer Survivors' Quality of Life

Some of the frequent venues publishing Susan Chan's work are:

  • PLoS ONE
  • Biochemical and Biophysical Research Communications
  • The Journal of Immunology
  • Proceedings of the National Academy of Sciences
  • The Journal of Experimental Medicine

The scientist has contributed to the following recent papers:

  • Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4+ T Cells, 2021, The Journal of Immunology
  • CD4+T cells require Ikaros to inhibit their differentiation toward a pathogenic cell fate, 2021, Proceedings of the National Academy of Sciences
  • Ikaros antagonizes DNA binding by STAT5 in pre-B cells, 2020, PLoS ONE
  • Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells, 2021, The Journal of Experimental Medicine
  • CD4+ regulatory T cells lacking Helios and Eos, 2023, Biochemical and Biophysical Research Communications

Frequent co-authors collaborating with Susan Chan include:

  • Philippe Kastner
  • Patricia Marchal
  • Beate Heizmann
  • Stéphanie Le Gras
  • Peggy Kirstetter

The scientist's work covers important areas related to immune cell roles in hematology and oncology, particularly focusing on T-cell functions, regulatory mechanisms involving transcription factors like Ikaros and Helios, and their impact on leukemia and immune response modulation. Their research complements studies on molecular biology and public health dimensions associated with immunological conditions and therapies.

Best Publications

  • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

    M Kobayashi;L Fitz;M Ryan;R M Hewick

  • Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

    Scott H Robbins;Thierry Walzer;Thierry Walzer;Doulaye Dembélé;Christelle Thibault

  • Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.

    Hiromi Iwasaki;Chamorro Somoza;Hirokazu Shigematsu;Estelle A. Duprez

  • CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice.

    S. Cardell;Shabnam Tangri;S. Chan;M. Kronenberg

  • Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

    Hye-Jung Kim;R. Anthony Barnitz;R. Anthony Barnitz;Taras Kreslavsky;Flavian D. Brown

  • Reciprocal Activation of GATA-1 and PU.1 Marks Initial Specification of Hematopoietic Stem Cells into Myeloerythroid and Myelolymphoid Lineages

    Yojiro Arinobu;Shin ichi Mizuno;Yong Chong;Hirokazu Shigematsu

  • A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.

    Wenxian Fu;Ayla Ergun;Ayla Ergun;Ting Lu;Ting Lu;Jonathan A Hill;Jonathan A Hill

  • MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.

    Thomas Delale;André Paquin;Carine Asselin-Paturel;Marc Dalod

  • Ikaros is critical for B cell differentiation and function

    Peggy Kirstetter;Mireille Thomas;Andrée Dierich;Philippe Kastner

  • Notch Activation Is an Early and Critical Event during T-Cell Leukemogenesis in Ikaros-Deficient Mice

    Alexis Dumortier;Robin Jeannet;Peggy Kirstetter;Eva Kleinmann

  • MafB restricts M-CSF-Dependent myeloid commitment divisions of hematopoietic stem cells

    Sandrine Sarrazin;Sandrine Sarrazin;Sandrine Sarrazin;Noushine Mossadegh-Keller;Noushine Mossadegh-Keller;Noushine Mossadegh-Keller;Taro Fukao;Taro Fukao;Taro Fukao;Athar Aziz;Athar Aziz;Athar Aziz

  • Ikaros is required for plasmacytoid dendritic cell differentiation

    David Allman;Marc Dalod;Carine Asselin-Paturel;Thomas Delale

  • PU.1 determines the self-renewal capacity of erythroid progenitor cells

    Jonathan Back;Andrée Dierich;Corinne Bronn;Philippe Kastner

  • Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade

    Juan Manuel Leyva-Castillo;Pierre Hener;Paula Michea;Paula Michea;Hajime Karasuyama

  • Positive and negative regulation of granulopoiesis by endogenous RARα

    Philippe Kastner;H. Jeffrey Lawrence;Caroline Waltzinger;Norbert B. Ghyselinck

  • Enhanced bone formation in lipodystrophic PPARγhyp/hyp mice relocates haematopoiesis to the spleen

    Terrie-Anne Cock;Jonathan Back;Florent Elefteriou;Gérard Karsenty

  • PU.1: a crucial and versatile player in hematopoiesis and leukemia.

    Philippe Kastner;Susan Chan

  • Visualizing PU.1 activity during hematopoiesis.

    Jonathan Back;David Allman;Susan Chan;Philippe Kastner

  • Ikaros Represses the Transcriptional Response to Notch Signaling in T-Cell Development

    Eva Kleinmann;Anne-Solen Geimer Le Lay;MacLean Sellars;Philippe Kastner

  • Ikaros is required for plasmacytoid dendritic cell differentiation. Commentary

    Marco Colonna;David Allman;Marc Dalod;Carine Asselin Paturel

Frequent Co-Authors

Philippe Kastner
Philippe Kastner Institute of Genetics and Molecular and Cellular Biology
Diane Mathis
Diane Mathis Harvard University
Christophe Benoist
Christophe Benoist Harvard University
Koichi Akashi
Koichi Akashi Kyushu University
Marc Dalod
Marc Dalod Centre d’Immunologie de Marseille-Luminy
Jacques Ghysdael
Jacques Ghysdael Centre national de la recherche scientifique, CNRS
Giorgio Trinchieri
Giorgio Trinchieri National Institutes of Health
Andrée Dierich
Andrée Dierich Institute of Genetics and Molecular and Cellular Biology
Stephanie Gras
Stephanie Gras La Trobe University
Raoul Herbrecht
Raoul Herbrecht University of Strasbourg

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