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D-Index & Metrics

Biology and Biochemistry

D-Index
43
Citations
11210
World Ranking
19354
National Ranking
923

Overview

Karine Crozat is a researcher affiliated with Aix-Marseille University in France, specializing primarily in the field of Immunology and Microbiology. Their work spans several subfields including Immunology, Neurology, Molecular Biology, Oncology, and Microbiology. The focus of their research includes multiple key topics: Immunotherapy and Immune Responses, T-cell and B-cell Immunology, Immune Cell Function and Interaction, Neuroinflammation and Neurodegeneration Mechanisms, Cancer Immunotherapy and Biomarkers, Immune cells in cancer, and Single-cell and spatial transcriptomics.

Crozat's recent publications demonstrate a sustained contribution to the immunology landscape, with notable papers such as:

  • "NF-κB-dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity," 2021, Science Immunology
  • "ImmGen at 15," 2020, Nature Immunology
  • "Meningeal macrophages protect against viral neuroinfection," 2022, Immunity
  • "Type 1 conventional dendritic cells and interferons are required for spontaneous CD4 + and CD8 + T-cell protective responses to breast cancer," 2021, Clinical & Translational Immunology
  • "Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8+ T cells," 2021, iScience

Their scholarly output has appeared frequently in prestigious venues, with multiple publications in bioRxiv (Cold Spring Harbor Laboratory), as well as single articles in Science Immunology, Nature Immunology, Immunity, and Clinical & Translational Immunology.

Collaborative work features prominently in Crozat's career, with regular co-authorship alongside researchers such as Marc Dalod, Florent Ginhoux, Carine Brousse, Bernard Malissen, and Toby Lawrence. These collaborations have contributed to advancing understanding in immune cell biology and cancer immunotherapy.

The research emphasis on immune system dynamics includes detailed study of dendritic cells, T-cell behavior, and neuroimmune interactions, addressing mechanisms relevant to cancer and infectious diseases. This multidisciplinary approach intersects immunology, neurology, and molecular biology to explore immune responses at cellular and molecular levels.

Best Publications

  • Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.

    K. Hoebe;X. Du;P. Georgel;E. Janssen

  • Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

    Koichi Tabeta;Philippe Georgel;Edith Janssen;Xin Du

  • CD36 is a sensor of diacylglycerides

    Kasper Hoebe;Philippe Georgel;Sophie Rutschmann;Xin Du

  • Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

    Bruce Beutler;Zhengfan Jiang;Philippe Georgel;Karine Crozat

  • The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.

    Koichi Tabeta;Kasper Hoebe;Edith M. Janssen;Xin Du

  • The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8α+ dendritic cells

    Karine Crozat;Rachel Guiton;Rachel Guiton;Vanessa Contreras;Vincent Feuillet;Vincent Feuillet

  • Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells.

    Martin Guilliams;Karine Crozat;Sandrine Henri;Samira Tamoutounour

  • Cutting edge: expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8α+ type.

    Karine Crozat;Samira Tamoutounour;Thien-Phong Vu Manh;Even Fossum

  • Genetic analysis of resistance to viral infection

    Bruce Beutler;Celine Eidenschenk;Karine Crozat;Jean Luc Imler

  • TLR7: A new sensor of viral infection

    K. Crozat;B. Beutler

  • A Toll-Like Receptor 2-Responsive Lipid Effector Pathway Protects Mammals against Skin Infections with Gram-Positive Bacteria

    Philippe Georgel;Karine Crozat;Xavier Lauth;Evgenia Makrantonaki

  • Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery

    Laurence Ardouin;Hervé Luche;Rabie Chelbi;Sabrina Carpentier

  • Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets.

    Karine Crozat;Rachel Guiton;Martin Guilliams;Sandrine Henri;Sandrine Henri

  • Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis

    Karine Crozat;Kasper Hoebe;Sophie Ugolini;Sophie Ugolini;Nancy A. Hong

  • Are Conventional Type 1 Dendritic Cells Critical for Protective Antitumor Immunity and How

    Jean-Charles Cancel;Karine Crozat;Marc Dalod;Raphaël Mattiuz

  • Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

    Zhengfan Jiang;Philippe Georgel;Philippe Georgel;Chenglong Li;Chenglong Li;Jungwoo Choe

  • Existence of CD8α-Like Dendritic Cells with a Conserved Functional Specialization and a Common Molecular Signature in Distant Mammalian Species

    Vanessa Contreras;Céline Urien;Rachel Guiton;Yannick Alexandre

  • Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the Periphery

    Michael J. Barnes;Philippe Krebs;Nathaniel Harris;Celine Eidenschenk

  • XCR1+ dendritic cells promote memory CD8+ T cell recall upon secondary infections with Listeria monocytogenes or certain viruses

    Yannick O. Alexandre;Sonia Ghilas;Cindy Sanchez;Agnès Le Bon

  • Plasmacytoid, conventional, and monocyte-derived dendritic cells undergo a profound and convergent genetic reprogramming during their maturation.

    Thien-Phong Vu Manh;Yannick O. Alexandre;Yannick O. Alexandre;Yannick O. Alexandre;Thomas Baranek;Thomas Baranek;Thomas Baranek;Karine Crozat;Karine Crozat;Karine Crozat

Frequent Co-Authors

Marc Dalod
Marc Dalod Centre d’Immunologie de Marseille-Luminy
Bruce Beutler
Bruce Beutler The University of Texas Southwestern Medical Center
Philippe Georgel
Philippe Georgel University of Strasbourg
Kasper Hoebe
Kasper Hoebe Johnson & Johnson (United States)
Bernard Malissen
Bernard Malissen Aix-Marseille University
Zhengfan Jiang
Zhengfan Jiang Peking University
Eric Vivier
Eric Vivier Aix-Marseille University
Elena Tomasello
Elena Tomasello Aix-Marseille University
Sandrine Henri
Sandrine Henri Centre d’Immunologie de Marseille-Luminy

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