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Biology and Biochemistry

D-Index
59
Citations
15329
World Ranking
12386
National Ranking
5303

Overview

Shujun Liu is a researcher affiliated with the University of Minnesota in the United States. Their work primarily spans the fields of medicine and biochemistry, genetics, and molecular biology.

Liu's research focuses on several subfields including molecular biology, oncology, immunology, biomedical engineering, and radiology, nuclear medicine, and imaging. Their scientific inquiries often address topics such as immunotherapy and immune responses, RNA modifications and cancer, epigenetics and DNA methylation, nanoplatforms for cancer theranostics, cancer immunotherapy and biomarkers, pain mechanisms and treatments, and ion channel regulation and function.

Several recent publications showcase the scope of Liu's research interests. These include:

  • Glutathione-Bioimprinted Nanoparticles Targeting of N6-methyladenosine FTO Demethylase as a Strategy against Leukemic Stem Cells, 2022, Small
  • Temperature sensitive liposome based cancer nanomedicine enables tumour lymph node immune microenvironment remodelling, 2023, Nature Communications
  • Gold Nanorods Exhibit Intrinsic Therapeutic Activity via Controlling N6-Methyladenosine-Based Epitranscriptomics in Acute Myeloid Leukemia, 2021, ACS Nano
  • Cardio-protective effect of tetrahydrocurcumin, the primary hydrogenated metabolite of curcumin in vivo and in vitro: Induction of apoptosis and autophagy via PI3K/AKT/mTOR pathways, 2021, European Journal of Pharmacology
  • Small Molecule Inhibitors of TET Dioxygenases: Bobcat339 Activity Is Mediated by Contaminating Copper(II), 2022, ACS Medicinal Chemistry Letters

Liu has frequently published in venues such as Scientific Reports, Frontiers in Oncology, Chemical Engineering Journal, Small, and Nature Communications. These journals reflect the interdisciplinary nature of their work, bridging medicine, molecular biology, and bioengineering.

Their collaborations include multiple joint works with coauthors such as Shunli Fu, Yongjun Liu, Na Zhang, Lili Chang, and Tong Gao, indicating a consistent engagement with researchers in allied specialties and a network of frequent research partnerships.

Best Publications

  • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.

    Muller Fabbri;Ramiro Garzon;Amelia Cimmino;Amelia Cimmino;Zhongfa Liu

  • MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.

    Ramiro Garzon;Shujun Liu;Muller Fabbri;Zhongfa Liu

  • miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts

    Anna M. Eiring;Jason G. Harb;Paolo Neviani;Christopher Garton

  • The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

    Paolo Neviani;Ramasamy Santhanam;Rossana Trotta;Mario Notari

  • Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine

    William Blum;Ramiro Garzon;Rebecca B. Klisovic;Sebastian Schwind

  • A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia

    John C. Byrd;Guido Marcucci;Mark R. Parthun;Jim J. Xiao

  • FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphocytic leukemia

    Paolo Neviani;Ramasamy Santhanam;Joshua J. Oaks;Anna M. Eiring

  • Phase I Study of Decitabine Alone or in Combination With Valproic Acid in Acute Myeloid Leukemia

    William Blum;Rebecca B. Klisovic;Bjoern Hackanson;Zhongfa Liu

  • Curcumin is a potent DNA hypomethylation agent.

    Zhongfa Liu;Zhiliang Xie;William Jones;Ryan E. Pavlovicz

  • Pro- and Antiinflammatory Cytokine Signaling: Reciprocal Antagonism Regulates Interferon-gamma Production by Human Natural Killer Cells

    Jianhua Yu;Min Wei;Brian Becknell;Rossana Trotta

  • CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets

    Jianhua Yu;Hsiaoyin Charlene Mao;Min Wei;Tiffany Hughes

  • Sp1/NFκB/HDAC/miR-29b Regulatory Network in KIT-Driven Myeloid Leukemia

    Shujun Liu;Lai Chu Wu;Jiuxia Pang;Ramasamy Santhanam

  • Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia

    Li Yu;Chunhui Liu;Jeff Vandeusen;Brian Becknell

  • Prognostic Significance of Expression of a Single MicroRNA, miR-181a, in Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

    Sebastian Schwind;Kati Maharry;Michael D. Radmacher;Krzysztof Mrózek

  • Aberrant Overexpression of IL-15 Initiates Large Granular Lymphocyte Leukemia through Chromosomal Instability and DNA Hypermethylation

    Anjali Mishra;Shujun Liu;Gregory H. Sams;Douglas P. Curphey

  • A dynamic N 6 -methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.

    Fei Yan;Aref Al-Kali;Zijie Zhang;Jun Liu

  • The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy.

    Susan P. Whitman;Shujun Liu;Tamara Vukosavljevic;Laura J. Rush

  • Phase I Study of Oblimersen Sodium, an Antisense to Bcl-2, in Untreated Older Patients With Acute Myeloid Leukemia: Pharmacokinetics, Pharmacodynamics, and Clinical Activity

    Guido Marcucci;Wendy Stock;Guowei Dai;Rebecca B. Klisovic

  • Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-κB–dependent DNA methyltransferase activity in acute myeloid leukemia

    Shujun Liu;Zhongfa Liu;Zhiliang Xie;Jiuxia Pang

  • Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia.

    Shujun Liu;Tiansheng Shen;Lenguyen Huynh;Marko I. Klisovic

Frequent Co-Authors

Guido Marcucci
Guido Marcucci City Of Hope National Medical Center
John C. Byrd
John C. Byrd University of Pittsburgh Cancer Institute
Michael A. Caligiuri
Michael A. Caligiuri City Of Hope National Medical Center
Michael R. Grever
Michael R. Grever The Ohio State University
Jianhua Yu
Jianhua Yu City Of Hope National Medical Center
Robert J. Lee
Robert J. Lee University of Pennsylvania
Susan P. Whitman
Susan P. Whitman The Ohio State University
Clara D. Bloomfield
Clara D. Bloomfield The Ohio State University
Mark R. Litzow
Mark R. Litzow Mayo Clinic
Christoph Plass
Christoph Plass German Cancer Research Center

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