Zhengfan Jiang

Overview

Best Publications

• Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

  Bruce Beutler;Zhengfan Jiang;Philippe Georgel;Karine Crozat

  970
  Citations

• ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

  Wenxiang Sun;Yang Li;Lu Chen;Huihui Chen

  883
  Citations

• CD14 is required for MyD88-independent LPS signaling

  Zhengfan Jiang;Philippe Georgel;Xin Du;Louis Shamel

  862
  Citations

• Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

  Chenguang Wang;Yukun Guan;Mengze Lv;Rui Zhang

  742
  Citations

• Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

  Mengze Lv;Mengze Lv;Meixia Chen;Rui Zhang;Wen Zhang;Wen Zhang

  594
  Citations

• Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β

  Zhengfan Jiang;Tak W. Mak;Ganes Sen;Xiaoxia Li

  524
  Citations

• Hypersusceptibility to Vesicular Stomatitis Virus Infection in Dicer1-Deficient Mice Is Due to Impaired miR24 and miR93 Expression

  Motoyuki Otsuka;Qing Jing;Philippe Georgel;Liguo New

  454
  Citations

• Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR

  Zhengfan Jiang;Maryam Zamanian-Daryoush;Huiqing Nie;Aristobolo M. Silva

  440
  Citations

• Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

  Huihui Chen;Hui Sun;Fuping You;Wenxiang Sun

  403
  Citations

• Interleukin-1 (IL-1) Receptor-Associated Kinase-Dependent IL-1-Induced Signaling Complexes Phosphorylate TAK1 and TAB2 at the Plasma Membrane and Activate TAK1 in the Cytosol

  Zhengfan Jiang;Jun Ninomiya-Tsuji;Youcun Qian;Kunihiro Matsumoto

  377
  Citations

• PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4.

  Fuping You;Hui Sun;Xiang Zhou;Wenxiang Sun

  345
  Citations

• STING directly activates autophagy to tune the innate immune response.

  Dong Liu;Hao Wu;Chenguang Wang;Yanjun Li

  303
  Citations

• Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3

  Xiaohan Ning;Yutao Wang;Yutao Wang;Miao Jing;Miao Jing;Mengyin Sha;Mengyin Sha

  302
  Citations

• Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.

  Philippe Georgel;Zhengfan Jiang;Stefan Kunz;Edith Janssen

  267
  Citations

• Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.

  Zhengfan Jiang;H. Jan Johnson;Huiqing Nie;Jinzhong Qin

  243
  Citations

• Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection

  Yutao Wang;Xiaohan Ning;Xiaohan Ning;Pengfei Gao;Pengfei Gao;Shuxian Wu

  240
  Citations

• The structural basis for the sensing and binding of cyclic di-GMP by STING

  Yi-He Huang;Xiang-Yu Liu;Xiao-Xia Du;Zheng-Fan Jiang

  228
  Citations

• A Toll-Like Receptor 2-Responsive Lipid Effector Pathway Protects Mammals against Skin Infections with Gram-Positive Bacteria

  Philippe Georgel;Karine Crozat;Xavier Lauth;Evgenia Makrantonaki

  226
  Citations

• IL-1-induced NFκB and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)

  Xiaoxia Li;Mairead Commane;Zhengfan Jiang;George R. Stark

  222
  Citations

• Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.

  Chun Zhou;Xia Chen;Xia Chen;Rosa Planells-Cases;Jiachen Chu

  220
  Citations