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C. William Shuttleworth

C. William Shuttleworth

D-Index & Metrics

Neuroscience

D-Index
39
Citations
5425
World Ranking
8368
National Ranking
3574

Overview

C. William Shuttleworth is affiliated with the University of New Mexico in the United States. Their research spans across medicine and neuroscience, with a strong focus on neurology, cellular and molecular neuroscience, and psychiatry and mental health. Additional subfields include cognitive neuroscience and molecular biology.

The scientist's work concentrates on several key topics: neuroscience and neuropharmacology research, traumatic brain injury and neurovascular disturbances, ion channel regulation and function, intracranial aneurysms including their treatment and complications, migraine and headache studies, cerebrospinal fluid and hydrocephalus, and functional brain connectivity studies.

Frequent co-authors associated with Shuttleworth include Andrew P. Carlson, K. C. Brennan, Katelyn M. Reinhart, Herbert Davis, and Thomas R. Jones.

Shuttleworth has contributed multiple research articles to several prominent venues. Among the most recurrent publication outlets are Neurocritical Care, bioRxiv (Cold Spring Harbor Laboratory), Journal of Neurochemistry, Journal of Neurosurgery, and Translational Stroke Research.

Recent notable publications include:

  • The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention (2022, Neurocritical Care)
  • Brain energy metabolism: A roadmap for future research (2024, Journal of Neurochemistry)
  • Non-canonical glutamate signaling in a genetic model of migraine with aura (2020, Neuron)
  • Spreading depolarization may represent a novel mechanism for delayed fluctuating neurological deficit after chronic subdural hematoma evacuation (2020, Journal of Neurosurgery)
  • Effect of Locally Delivered Nimodipine Microparticles on Spreading Depolarization in Aneurysmal Subarachnoid Hemorrhage (2020, Neurocritical Care)

Best Publications

  • The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão's legacy

    Jed A Hartings;C William Shuttleworth;Sergei A Kirov;Cenk Ayata

  • Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

    Jens P. Dreier;Martin Fabricius;Cenk Ayata;Oliver W. Sakowitz

  • Co-localization of nitric oxide synthase immunoreactivity and NADPH diaphorase staining in neurons of the guinea-pig intestine.

    H. M. Young;J. B. Furness;C. W R Shuttleworth;D. S. Bredt

  • NADPH diaphorase and nitric oxide synthase colocalization in enteric neurons of canine proximal colon.

    S. M. Ward;Chun Xue;C. W. Shuttleworth;D. S. Bredt

  • Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia.

    Y. V. Medvedeva;B. Lin;C. W. Shuttleworth;J. H. Weiss

  • Zinc: new clues to diverse roles in brain ischemia.

    C. William Shuttleworth;John H. Weiss

  • NAD(P)H fluorescence imaging of postsynaptic neuronal activation in murine hippocampal slices.

    C. William Shuttleworth;Angela M. Brennan;John A. Connor

  • Immunohistochemical localization of 3',5'-cyclic guanosine monophosphate in the canine proximal colon: Responses to nitric oxide and electrical stimulation of enteric inhibitory neurons

    C.W. Shuttleworth;C. Xue;S.M. Ward;J. De Vente

  • Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial.

    Andrew P Carlson;Mohammad Abbas;Robert L Alunday;Fares Qeadan

  • Zn2+ Influx Is Critical for Some Forms of Spreading Depression in Brain Slices

    Robert M Dietz;John H Weiss;Claude W Shuttleworth

  • NAD(P)H fluorescence transients after synaptic activity in brain slices: predominant role of mitochondrial function.

    Angela M Brennan;John A Connor;C William Shuttleworth

  • The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention

    Unknown

  • Use of NAD(P)H and flavoprotein autofluorescence transients to probe neuron and astrocyte responses to synaptic activation.

    C. William Shuttleworth

  • Neural stem/progenitor cells display a low requirement for oxidative metabolism independent of hypoxia inducible factor‐1alpha expression

    Kate M. Candelario;C. William Shuttleworth;Lee Anna Cunningham

  • Sustained NMDA receptor activation by spreading depolarizations can initiate excitotoxic injury in metabolically compromised neurons

    Isamu Aiba;C. William Shuttleworth

  • Light- and electron-microscopic immunochemical analysis of nerve fibre types innervating the taenia of the guinea-pig caecum

    J. B. Furness;S. Pompolo;C. W. R. Shuttleworth;D. E. Burleigh

  • Strain-dependent differences in calcium signaling predict excitotoxicity in murine hippocampal neurons.

    C. William R. Shuttleworth;John A. Connor

  • Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury?

    Jessica L. Seidel;Carole Escartin;Cenk Ayata;Gilles Bonvento

  • Direct visualization of trapped erythrocytes in rat brain after focal ischemia and reperfusion.

    Shimin Liu;John Connor;Steven Peterson;C William Shuttleworth

  • Calcium-dependent NMDA-induced dendritic injury and MAP2 loss in acute hippocampal slices

    M.M. Hoskison;Y. Yanagawa;K. Obata;C.W. Shuttleworth

  • Microtubule disruption, not calpain-dependent loss of MAP2, contributes to enduring NMDA-induced dendritic dysfunction in acute hippocampal slices.

    M.M. Hoskison;C. William Shuttleworth

  • Direct current electrocorticography for clinical neuromonitoring of spreading depolarizations.

    Jed A Hartings;Chunyan Li;Chunyan Li;Jason M Hinzman;C William Shuttleworth

  • Localized Loss of Ca2+ Homeostasis in Neuronal Dendrites Is a Downstream Consequence of Metabolic Compromise during Extended NMDA Exposures

    Thomas A. Vander Jagt;John A. Connor;C. William Shuttleworth

  • Non-canonical glutamate signaling in a genetic model of migraine with aura.

    Patrick D. Parker;Pratyush Suryavanshi;Marcello Melone;Punam A. Sawant-Pokam

Frequent Co-Authors

John A. Connor
John A. Connor University of New Mexico
Jed A. Hartings
Jed A. Hartings University of Cincinnati
Jens P. Dreier
Jens P. Dreier Charité - University Medicine Berlin
Cenk Ayata
Cenk Ayata Harvard University
Martin Fabricius
Martin Fabricius University of Copenhagen
Sergei A. Kirov
Sergei A. Kirov Augusta University
John H. Weiss
John H. Weiss University of California, Irvine
Gilles Bonvento
Gilles Bonvento University of Paris-Saclay
Marcello Melone
Marcello Melone Marche Polytechnic University
Brian A. MacVicar
Brian A. MacVicar University of British Columbia

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