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Neuroscience

D-Index
61
Citations
13490
World Ranking
3678
National Ranking
1687

Overview

John H. Weiss is affiliated with the University of California, Irvine in the United States. Their research spans key areas within Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on mitochondrial function and pathology, trace elements in health, infectious encephalopathies and encephalitis, lysosomal storage disorders, and neurogenetic and muscular disorders.

The scientist has contributed to multiple topics, including:

  • Mitochondrial Function and Pathology
  • Trace Elements in Health
  • Infectious Encephalopathies and Encephalitis
  • Lysosomal Storage Disorders Research
  • Neurogenetic and Muscular Disorders Research
  • Alzheimer's Disease Research and Treatments
  • Parkinson's Disease Mechanisms and Treatments

Their work is often situated in the subfields of Molecular Biology, Nutrition and Dietetics, Infectious Diseases, Physiology, and Genetics.

John H. Weiss has published research in a selection of scientific journals, including:

  • Biomedicines
  • Journal of Translational Medicine
  • Journal of Neuroscience
  • Preprints.org
  • Frontiers in Neuroscience

Recent papers authored or coauthored by Weiss include:

  • The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction, 2021, Biomedicines
  • VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy, 2022, Journal of Translational Medicine
  • Blocking Mitochondrial Zn2+ Accumulation after Ischemia Reduces Mitochondrial Dysfunction and Neuronal Injury, 2022, Journal of Neuroscience
  • The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction, 2021, Preprints.org
  • Editorial: Excitotoxicity Turns 50. The Death That Never Dies, 2022, Frontiers in Neuroscience

Frequent coauthors collaborating with Weiss include:

  • Hong Yin
  • Lan Weiss
  • Alyaa Shmara
  • Lac Ta
  • Virginia Kimonis

The research efforts of John H. Weiss focus heavily on the mechanisms underlying mitochondrial health and disease, as well as the role of trace elements such as zinc in neurological function and pathology. Their work also encompasses studies related to muscle pathology, lysosomal storage disorders, and neurodegenerative diseases, contributing to an interdisciplinary understanding of cellular and molecular mechanisms in health and disease contexts.

Best Publications

  • Zn2+: a novel ionic mediator of neural injury in brain disease

    John H Weiss;Stefano L Sensi;Jae Y Koh

  • Motor Neurons Are Selectively Vulnerable to AMPA/Kainate Receptor-Mediated Injury In Vitro

    Sean G. Carriedo;Hong Z. Yin;John H. Weiss

  • Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration.

    DM Hartley;MC Kurth;L Bjerkness;JH Weiss

  • Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production

    Stefano L. Sensi;Hong Z. Yin;Sean G. Carriedo;Shyam S. Rao

  • Modulation of mitochondrial function by endogenous Zn2+ pools.

    Stefano L. Sensi;Dien Ton-That;Patrick G. Sullivan;Elizabeth A. Jonas

  • N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture.

    M. P. Goldberg;J. H. Weiss;Phuong-Chi Pham;D. W. Choi

  • AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro.

    Sean G. Carriedo;Stefano L. Sensi;Hong Z. Yin;John H. Weiss

  • Ca2+–Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration

    John H Weiss;Stefano L Sensi

  • The Calcium Channel Blocker Nifedipine Attenuates Slow Excitatory Amino Acid Neurotoxicity

    JH Weiss;DM Hartley;J Koh;DW Choi

  • AMPA receptor activation potentiates zinc neurotoxicity.

    John H. Weiss;Dean M. Hartley;Jae-young Koh;Dennis W. Choi

  • Zn2+ Induces Permeability Transition Pore Opening and Release of Pro-apoptotic Peptides from Neuronal Mitochondria

    Dongmei Jiang;Patrick G. Sullivan;Stefano L. Sensi;Oswald Steward

  • Rapid Communication: Ca2+ Channel Blockers Attenuate β‐Amyloid Peptide Toxicity to Cortical Neurons in Culture

    John H. Weiss;Christian J. Pike;Carl W. Cotman

  • Calcium-permeable AMPA channels in neurodegenerative disease and ischemia

    Shin Kwak;John H Weiss

  • Beta-N-methylamino-L-alanine neurotoxicity: requirement for bicarbonate as a cofactor.

    John H. Weiss;Dennis W. Choi

  • BMAA selectively injures motor neurons via AMPA/kainate receptor activation.

    Shyam D. Rao;Sandra Anne Banack;Paul Alan Cox;John H. Weiss

  • Neurotoxicity of beta-N-methylamino-L-alanine (BMAA) and beta-N-oxalylamino-L-alanine (BOAA) on cultured cortical neurons.

    John H. Weiss;Jae-young Koh;Dennis W. Choi

  • Rapid Ca2+ Entry through Ca2+-Permeable AMPA/Kainate Channels Triggers Marked Intracellular Ca2+Rises and Consequent Oxygen Radical Production

    Sean G. Carriedo;Hong Zhen Yin;Stefano L. Sensi;John H. Weiss

  • Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis.

    Shyam D Rao;John H Weiss

  • AMPA/kainate receptor-triggered Zn2+ entry into cortical neurons induces mitochondrial Zn2+ uptake and persistent mitochondrial dysfunction.

    Stefano L. Sensi;Hong Z. Yin;John H. Weiss

  • Tumor necrosis-factor-alpha (TNF-α) induces rapid insertion of Ca2+-permeable α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons

    Fumio Ogoshi;Hong Zhen Yin;Yuvarani Kuppumbatti;Bora Song

  • Blockade of Ca2+-Permeable AMPA/Kainate Channels Decreases Oxygen–Glucose Deprivation-Induced Zn2+Accumulation and Neuronal Loss in Hippocampal Pyramidal Neurons

    Hong Z. Yin;Stefano L. Sensi;Fumio Ogoshi;John H. Weiss

Frequent Co-Authors

Dennis W. Choi
Dennis W. Choi Stony Brook University
Richard T. Robertson
Richard T. Robertson University of California, Irvine
C. William Shuttleworth
C. William Shuttleworth University of New Mexico
Patrick G. Sullivan
Patrick G. Sullivan University of Kentucky
Elias Aizenman
Elias Aizenman University of Pittsburgh
Linda S. Sorkin
Linda S. Sorkin University of California, San Diego
Vincent Procaccio
Vincent Procaccio University of Angers
Birgitta Bergman
Birgitta Bergman Stockholm University
Yong-hui Jiang
Yong-hui Jiang Yale School of Medicine
Douglas C. Wallace
Douglas C. Wallace Children's Hospital of Philadelphia

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