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Neuroscience

D-Index
82
Citations
25918
World Ranking
1502
National Ranking
81

Research.com Recognitions

  • 2007 - Fellow of the Royal Society of Canada Academy of Science
  • 1986 - Fellow of Alfred P. Sloan Foundation

Overview

Brian A. MacVicar is affiliated with the University of British Columbia in Canada. Their research focuses primarily on Neuroscience, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these fields, their work spans several subfields including Neurology, Molecular Biology, Cellular and Molecular Neuroscience, Immunology, and Physiology.

The main topics covered in Brian A. MacVicar's scholarly output include Neuroinflammation and Neurodegeneration Mechanisms, Neuroscience and Neuropharmacology Research, Immune Response and Inflammation, Barrier Structure and Function Studies, Alzheimer's disease research and treatments, Neurogenesis and neuroplasticity mechanisms, and Immune cells in cancer.

Their recent publications illustrate a breadth of investigation in neuroscience and immunometabolic functions:

  • "Reactive astrocyte nomenclature, definitions, and future directions" (2021, Nature Neuroscience)
  • "Microglial metabolic flexibility supports immune surveillance of the brain parenchyma" (2020, Nature Communications)
  • "Immunometabolism in the Brain: How Metabolism Shapes Microglial Function" (2020, Trends in Neurosciences)
  • "Mitochondrial Ca2+ uptake by the MCU facilitates pyramidal neuron excitability and metabolism during action potential firing" (2022, Communications Biology)
  • "Neuroinflammatory inhibition of synaptic long-term potentiation requires immunometabolic reprogramming of microglia" (2020, Glia)

Brian A. MacVicar frequently collaborates with several coauthors, including Louis-Philippe Bernier, Nicholas L. Weilinger, Stefan Wendt, Hyun B. Choi, and Christopher J. Groten. The partnerships with these coauthors have resulted in multiple publications, with Louis-Philippe Bernier particularly notable for thirteen joint works.

Their research has been published in various venues, with notable recurring publications in bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, Nature Neuroscience, Glia, and JCI Insight.

Brian A. MacVicar has been recognized for their contributions with awards such as the Fellowship of the Royal Society of Canada in 2007, specifically within the Academy of Science, and the Fellowship of the Alfred P. Sloan Foundation in 1986.

Best Publications

  • Glial and neuronal control of brain blood flow.

    David Attwell;Alastair M. Buchan;Serge Charpak;Martin Lauritzen

  • Reactive astrocyte nomenclature, definitions, and future directions

    Carole Escartin;Elena Galea;András Lakatos;James P. O’Callaghan

  • Calcium transients in astrocyte endfeet cause cerebrovascular constrictions

    Sean J. Mulligan;Brian A. MacVicar

  • Brain metabolism dictates the polarity of astrocyte control over arterioles

    Grant R. J. Gordon;Hyun B. Choi;Ravi L. Rungta;Graham C. R. Ellis-Davies

  • Microglia: Dynamic Mediators of Synapse Development and Plasticity.

    Yuwen Wu;Yuwen Wu;Lasse Dissing-Olesen;Lasse Dissing-Olesen;Brian A. MacVicar;Beth Stevens;Beth Stevens

  • Ischemia opens neuronal gap junction hemichannels.

    Roger J. Thompson;Ning Zhou;Brian A. MacVicar

  • Astrocyte Regulation of Blood Flow in the Brain

    Brian A. MacVicar;Eric A. Newman

  • Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus

    Roger J. Thompson;Michael F. Jackson;Michelle E. Olah;Ravi L. Rungta

  • Astrocyte control of the cerebrovasculature.

    Grant R. J. Gordon;Sean J. Mulligan;Brian A. MacVicar

  • Voltage-dependent calcium channels in glial cells

    BA MacVicar

  • Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

    Jens P. Dreier;Martin Fabricius;Cenk Ayata;Oliver W. Sakowitz

  • Imaging cell volume changes and neuronal excitation in the hippocampal slice.

    R.D. Andrew;B.A. Macvicar

  • Imaging of synaptically evoked intrinsic optical signals in hippocampal slices

    BA MacVicar;D Hochman

  • Electrotonic coupling between pyramidal cells: a direct demonstration in rat hippocampal slices

    BA MacVicar;BA MacVicar;FE Dudek

  • Activation of neuronal NMDA receptors triggers transient ATP-mediated microglial process outgrowth.

    Lasse Dissing-Olesen;Jeffrey M LeDue;Ravi L Rungta;Jasmin K Hefendehl

  • Non-junction functions of pannexin-1 channels

    Brian A. MacVicar;Roger J. Thompson

  • Microglial metabolic flexibility supports immune surveillance of the brain parenchyma.

    Louis-Philippe Bernier;Elisa M. York;Alireza Kamyabi;Hyun B. Choi

  • P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase.

    William Panenka;Humberto Jijon;Leonie M. Herx;John N. Armstrong

  • Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase.

    Jingfei Zhang;Aqsa Malik;Hyun B. Choi;Rebecca W.Y. Ko

  • Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase.

    Hyun B. Choi;Grant R.J. Gordon;Ning Zhou;Ning Zhou;Chao Tai

  • Imaging Spreading Depression and Associated Intracellular Calcium Waves in Brain Slices

    Trent A. Basarsky;Steven N. Duffy;R. David Andrew;Brian A. MacVicar

Frequent Co-Authors

Quentin J. Pittman
Quentin J. Pittman University of Calgary
Martin Lauritzen
Martin Lauritzen University of Copenhagen
Glenn I. Hatton
Glenn I. Hatton Michigan State University
Beth Stevens
Beth Stevens Boston Children's Hospital
Graham C. R. Ellis-Davies
Graham C. R. Ellis-Davies Icahn School of Medicine at Mount Sinai
Samuel Weiss
Samuel Weiss University of Calgary
F. Edward Dudek
F. Edward Dudek University of Utah
Gerald W. Zamponi
Gerald W. Zamponi University of Calgary
Nicola R. Sibson
Nicola R. Sibson University of Oxford
Arn M. J. M. van den Maagdenberg
Arn M. J. M. van den Maagdenberg Leiden University Medical Center

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