World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
99
Citations
32308
World Ranking
1353
National Ranking
521

Biology and Biochemistry

D-Index
101
Citations
33355
World Ranking
1465
National Ranking
833

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Palmer Taylor is affiliated with the University of California, San Diego in the United States. Their research primarily spans the fields of Agricultural and Biological Sciences, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these areas, their work frequently touches on Pharmacology, Molecular Biology, Plant Science, Insect Science, and Computational Theory and Mathematics.

The scientist's research interests focus on several key topics, including:

  • Cholinesterase and Neurodegenerative Diseases
  • Pesticide Exposure and Toxicity
  • Nicotinic Acetylcholine Receptors Study
  • Insect and Pesticide Research
  • Computational Drug Discovery Methods
  • Ion Channel Regulation and Function
  • Drug Transport and Resistance Mechanisms

Palmer Taylor has authored multiple papers in prestigious journals. Notable recent publications include:

  • "Rational design, synthesis, and evaluation of uncharged, 'smart' bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase," 2020, Journal of Biological Chemistry
  • "Lessons from nature: Structural studies and drug design driven by a homologous surrogate from invertebrates, AChBP," 2020, Neuropharmacology
  • "Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects," 2021, Journal of Biological Chemistry
  • "Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical," 2021, Journal of Neurochemistry
  • "Interactions of Nereistoxin and Its Analogs with Vertebrate Nicotinic Acetylcholine Receptors and Molluscan ACh Binding Proteins," 2022, Marine Drugs

Key publication venues where Palmer Taylor has frequently contributed include:

  • Journal of Biological Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
  • The FASEB Journal
  • Journal of Neurochemistry
  • Marine Drugs

Collaborations have been established with several frequent co-authors such as Zoran Radić, Kwok-Yiu Ho, K. Barry Sharpless, Oksana Gerlits, and Xiaolin Cheng.

In recognition of their scientific contributions, Palmer Taylor was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2007.

Best Publications

  • Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks

    Warren G. Lewis;Luke G. Green;Flavio Grynszpan;Zoran Radić

  • The Cholinesterases: From Genes to Proteins

    Taylor P;Radić Z

  • Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations.

    Scott B Hansen;Gerlind Sulzenbacher;Tom Huxford;Pascale Marchot

  • International Union of Pharmacology. XX. Current Status of the Nomenclature for Nicotinic Acetylcholine Receptors and Their Subunits

    R. J. Lukas;J.-P. Changeux;N. Le Novere;E. X. Albuquerque

  • Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors.

    Zoran Radic;Natilie A. Pickering;Daniel C. Vellom;Shelley Camp

  • Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence.

    Mark Schumacher;Shelley Camp;Yves Maulet;Michael Newton

  • In situ click chemistry: enzyme inhibitors made to their own specifications.

    Roman Manetsch;Antoni Krasiński;Zoran Radić;Jessica Raushel

  • A Splice Code for trans-Synaptic Cell Adhesion Mediated by Binding of Neuroligin 1 to α- and β-Neurexins

    Antony A. Boucard;Alexander A. Chubykin;Davide Comoletti;Palmer Taylor

  • Acetylcholinesterase Inhibition by Fasciculin: Crystal Structure of the Complex

    Yves Bourne;Yves Bourne;Palmer Taylor;Pascale Marchot

  • Interaction of fluorescence probes with acetylcholinesterase. The site and specificity of propidium binding.

    Palmer Taylor;Shelley Lappi

  • In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors.

    Antoni Krasiński;Zoran Radić;Roman Manetsch;Jessica Raushel

  • Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site

    Yves Bourne;Palmer Taylor;Zoran Radić;Pascale Marchot

  • Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity.

    Daniel C. Vellom;Zoran Radic;Ying Li;Natilie A. Pickering

  • LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation

    Joris de Wit;Emily Sylwestrak;Matthew L. O'Sullivan;Stefanie Otto

  • Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation.

    Yves Bourne;Hartmuth C. Kolb;Zoran Radić;K. Barry Sharpless

  • Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α-neurotoxins and nicotinic receptors

    Yves Bourne;Todd T Talley;Scott B Hansen;Palmer Taylor

  • Current progress on esterases: from molecular structure to function.

    Tetsuo Satoh;Palmer Taylor;William F. Bosron;Sonal P. Sanghani

  • Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel

    Cecilia Beatriz Bouzat;Fernanda Andrea Gumilar;Guillermo Federico Spitzmaul;Hai Long Wang

  • Postnatal Developmental Delay and Supersensitivity to Organophosphate in Gene-Targeted Mice Lacking Acetylcholinesterase

    Weihua Xie;Judith A. Stribley;Arnaud Chatonnet;Phillip J. Wilder

  • Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase. Distinctions between active center ligands and fasciculin.

    Zoran Radić;Paul D. Kirchhoff;Daniel M. Quinn;J. Andrew McCammon

Frequent Co-Authors

K. Barry Sharpless
K. Barry Sharpless Scripps Research Institute
Steven M. Sine
Steven M. Sine Mayo Clinic
Yves Bourne
Yves Bourne Aix-Marseille University
Bhupendra P. Doctor
Bhupendra P. Doctor Walter Reed Army Institute of Research
Valery V. Fokin
Valery V. Fokin University of Southern California
Tony L. Yaksh
Tony L. Yaksh University of California, San Diego
J. Andrew McCammon
J. Andrew McCammon University of California, San Diego
Jordi Molgó
Jordi Molgó Centre national de la recherche scientifique, CNRS
Mark H. Ellisman
Mark H. Ellisman University of California, San Diego
Susan S. Taylor
Susan S. Taylor University of California, San Diego

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