Steven M. Sine

Overview

Best Publications

• Data transformations for improved display and fitting of single-channel dwell time histograms

  F.J. Sigworth;S.M. Sine

  1140
  Citations

• Recent advances in Cys-loop receptor structure and function.

  Steven M. Sine;Andrew G. Engel

  654
  Citations

• Congenital myasthenic syndromes: pathogenesis, diagnosis, and treatment.

  Andrew G. Engel;Xin Ming Shen;Duygu Selcen;Steven M. Sine

  588
  Citations

• Principal pathway coupling agonist binding to channel gating in nicotinic receptors

  Won Yong Lee;Steven M. Sine

  384
  Citations

• Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel

  Cecilia Beatriz Bouzat;Fernanda Andrea Gumilar;Guillermo Federico Spitzmaul;Hai Long Wang

  341
  Citations

• Mutation of the acetylcholine receptor α subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

  Steven M. Sine;Kinji Ohno;Cecilia Bouzat;Anthony Auerbach

  315
  Citations

• Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit.

  Kinji Ohno;David O. Hutchinson;Margherita Milone;Joan M. Brengman

  305
  Citations

• Congenital Myasthenic Syndrome Caused by Decreased Agonist Binding Affinity Due to a Mutation in the Acetylcholine Receptor ε Subunit

  Kinji Ohno;Hai Long Wang;Margherita Milone;Nina Bren

  271
  Citations

• Functional consequences of agonist-mediated state transitions in the cholinergic receptor. Studies in cultured muscle cells.

  S Sine;P Taylor

  262
  Citations

• Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities.

  Steven M. Sine;Toni Claudio;Fred J. Sigworth

  259
  Citations

• Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1.

  Inés Ibañez-Tallon;Julie M. Miwa;Hai Long Wang;Niels C. Adams

  256
  Citations

• New Mutations in Acetylcholine Receptor Subunit Genes Reveal Heterogeneity in the Slow-Channel Congenital Myasthenic Syndrome

  Andrew G. Engel;Kinji Ohno;Margherita Milone;Hai Long Wang

  251
  Citations

• Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity

  Steven M. Sine

  246
  Citations

• Detection and trapping of intermediate states priming nicotinic receptor channel opening

  Nuriya Mukhtasimova;Won Yong Lee;Hai Long Wang;Steven M. Sine

  235
  Citations

• Sleuthing molecular targets for neurological diseases at the neuromuscular junction

  Andrew G. Engel;Kinji Ohno;Steven M. Sine

  230
  Citations

• The nicotinic receptor ligand binding domain

  Steven M. Sine

  229
  Citations

• Gamma- and delta-subunits regulate the affinity and the cooperativity of ligand binding to the acetylcholine receptor.

  Steven M. Sine;Toni Claudio

  225
  Citations

• Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist.

  Shu Xing Li;Sun Huang;Nina Bren;Kaori Noridomi

  221
  Citations

• Current understanding of congenital myasthenic syndromes

  Andrew G Engel;Steven M Sine

  213
  Citations

• Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating.

  Hai Long Wang;Margherita Milone;Kinji Ohno;Xing Ming Shen

  139
  Citations