World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
11610
World Ranking
9392
National Ranking
4142

Overview

Roger L. Papke is affiliated with the University of Florida in the United States and has a research profile centered on the biochemistry, genetics, and molecular biology fields. Their work primarily focuses on molecular biology, with further involvement in pharmacology, cellular and molecular neuroscience, neurology, and insect science as subfields of study.

Their main research topics cover various aspects of nicotinic acetylcholine receptors, including their signaling and pharmacological receptor mechanisms. Key areas include receptor mechanisms and signaling, ion channel regulation and function, cholinesterase and neurodegenerative diseases, vagus nerve stimulation research, and neuropeptides and animal physiology.

Recent publications by Roger L. Papke highlight several contributions to neuroscience and pharmacology. These include:

  • "Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling," 2020, Neuropharmacology
  • "Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors," 2021, Pharmacological Reviews
  • "Cholinergic Receptors and Addiction," 2020, Current Topics in Behavioral Neurosciences

Their research has appeared frequently in key scientific journals, notably Neuropharmacology, Molecular Pharmacology, ACS Chemical Neuroscience, Journal of Medicinal Chemistry, and Pharmacological Reviews. Neuropharmacology, Molecular Pharmacology, and ACS Chemical Neuroscience each host four of their publications, while the Journal of Medicinal Chemistry and Pharmacological Reviews have published fewer.

Collaboration is a notable aspect of their work, with frequent coauthors including Clare Stokes, Nicole A. Horenstein, Alican Gulsevin, Katrin Richter, and Veronika Grau. These collaborations contribute to advancing knowledge in their primary research areas.

Best Publications

  • An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype.

    Roger L. Papke;Merouane Bencherif;Patrick Lippiello

  • Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit.

    R L Papke;S F Heinemann

  • Comparative pharmacology of rat and human α7 nAChR conducted with net charge analysis

    Roger L Papke;Julia K Porter Papke

  • Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations

    Dustin K. Williams;Jingyi Wang;Roger L. Papke

  • Analysis of Mecamylamine Stereoisomers on Human Nicotinic Receptor Subtypes

    Papke Rl;Sanberg Pr;Shytle Rd

  • Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha 7/125I-alpha-bungarotoxin receptor subtypes.

    C M de Fiebre;E M Meyer;J C Henry;S I Muraskin

  • Single-channel currents of rat neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes

    Roger L. Papke;Jim Boulter;Jim Patrick;Steve Heinemann

  • 3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat α7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner

    Edwin M Meyer;Ee Tein Tay;Roger L Papke;Craig Meyers

  • Merging old and new perspectives on nicotinic acetylcholine receptors

    Roger L. Papke

  • A novel nicotinic agonist facilitates induction of long-term potentiation in the rat hippocampus

    Bruce E. Hunter;Christopher M. de Fiebre;Roger L. Papke;William R. Kem

  • TC-5619: An alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

    T.A. Hauser;A. Kucinski;K.G. Jordan;G.J. Gatto

  • Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat alpha-7 nicotinic receptors.

    Edwin M. Meyer;Alexander Kuryatov;Volodymyr Gerzanich;Jon Lindstrom

  • Neurobiology of Lithium: An Update

    Robert H. Lenox;Robert K. McNamara;Roger L. Papke;Husseini K. Manji

  • The kinetic properties of neuronal nicotinic receptors: genetic basis of functional diversity.

    Roger L. Papke

  • Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors.

    William R. Kem;Vladimir M. Mahnir;Roger L. Papke;Christopher J. Lingle

  • Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration.

    William R. Kem;Vladimir M. Mahnir;Laszlo Prokai;Roger L. Papke

  • Characterization of the neuroprotective and toxic effects of α7 nicotinic receptor activation in PC12 cells

    Yangxin Li;Roger L Papke;Yun-Ju He;William J Millard

  • α7 Receptor-selective agonists and modes of α7 receptor activation

    Roger L. Papke;Edwin Meyer;Tom Nutter;Vladimir V. Uteshev

  • The role of the beta 4‐subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3‐receptors.

    R L Papke;S F Heinemann

  • Investigation of the Molecular Mechanism of the α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator PNU-120596 Provides Evidence for Two Distinct Desensitized States

    Dustin K. Williams;Jingyi Wang;Roger L. Papke

Frequent Co-Authors

Edwin M. Meyer
Edwin M. Meyer University of Florida
Peter A. Crooks
Peter A. Crooks University of Arkansas for Medical Sciences
Linda P. Dwoskin
Linda P. Dwoskin University of Kentucky
Marina R. Picciotto
Marina R. Picciotto Yale University
Michael A. King
Michael A. King University of Florida
Robert H. Lenox
Robert H. Lenox University of New England
Stephen F. Heinemann
Stephen F. Heinemann Salk Institute for Biological Studies
J. Michael McIntosh
J. Michael McIntosh University of Utah
Jon Lindstrom
Jon Lindstrom University of Pennsylvania
Michael T. Bardo
Michael T. Bardo University of Kentucky

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring online education can open diverse career paths for students of Biology and Biochemistry. For those interested in the intersection of medicine and technology, health information management is a growing field. Earning a bachelor's degree health information management can prepare you for roles managing medical records and healthcare data, all from the convenience of online study.

Another option is the rapidly expanding nutrition field. Advanced credentials, such as an online nutrition masters, can boost your expertise and your career prospects in public health, wellness, or clinical nutrition.

If technology interests you, online ultrasound tech school programs offer a pathway to become a diagnostic medical sonographer—a vital, hands-on healthcare role that is in demand.

Career stability is important to consider. Some may wonder, is medical coding a dying career? While technology may shift the industry, evolving skills and certifications help maintain job relevance. Overall, online degrees provide a flexible and affordable way to advance in a range of science-related careers.

Best Scientists Citing Roger L. Papke

Trending Scientists

Recently Published Articles