What is he best known for?
The fields of study he is best known for:
Joel L. Sussman mainly focuses on Stereochemistry, Biochemistry, Active site, Protein structure and Acetylcholinesterase.
His Stereochemistry research is multidisciplinary, relying on both Hydrolase, Crystallography, Crystal structure, Catalytic triad and Serine hydrolase.
His Catalytic triad research includes themes of Haloalkane dehalogenase, Cholinesterase, Acyl binding, Butyrylcholinesterase and Histidine.
The concepts of his Active site study are interwoven with issues in Lysozyme, Indole test, Synchrotron, Substrate and Binding site.
His work in the fields of Protein structure, such as Protein Data Bank, overlaps with other areas such as Dipole.
His biological study spans a wide range of topics, including Torpedo, Cholinergic and Acetylcholine, Pharmacology.
His most cited work include:
- Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein (2161 citations)
- The α/β hydrolase fold (1726 citations)
- FoldIndex©: a simple tool to predict whether a given protein sequence is intrinsically unfolded (783 citations)
What are the main themes of his work throughout his whole career to date?
Stereochemistry, Acetylcholinesterase, Biochemistry, Torpedo and Crystallography are his primary areas of study.
The various areas that Joel L. Sussman examines in his Stereochemistry study include Hydrolase, Catalytic triad, Active site, Protein structure and Binding site.
His Active site research is multidisciplinary, incorporating perspectives in Docking, Substrate, Hydrogen bond and Molecular dynamics.
His Acetylcholinesterase study combines topics in areas such as Biophysics, Acetylcholine, Pharmacology and Cholinergic.
His work is connected to Enzyme and Peptide sequence, as a part of Biochemistry.
Joel L. Sussman has included themes like X-ray crystallography, Duplex, DNA and Transfer RNA in his Crystallography study.
He most often published in these fields:
- Stereochemistry (35.25%)
- Acetylcholinesterase (32.82%)
- Biochemistry (25.94%)
What were the highlights of his more recent work (between 2011-2021)?
- Acetylcholinesterase (32.82%)
- Stereochemistry (35.25%)
- Enzyme (16.85%)
In recent papers he was focusing on the following fields of study:
His main research concerns Acetylcholinesterase, Stereochemistry, Enzyme, Torpedo and Biophysics.
In general Acetylcholinesterase study, his work on Tabun often relates to the realm of Structure function, Injury control and Substrate, thereby connecting several areas of interest.
His studies in Stereochemistry integrate themes in fields like Hydrolase, Cyclosarin and Crystal structure.
His studies deal with areas such as Enzyme catalysis, Active site, Protein evolution, Protein structure and Reversion as well as Hydrolase.
To a larger extent, Joel L. Sussman studies Biochemistry with the aim of understanding Enzyme.
His work deals with themes such as Agonist, σ1 receptor and Binding site, which intersect with Torpedo.
Between 2011 and 2021, his most popular works were:
- JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia (163 citations)
- Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. (157 citations)
- Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. (156 citations)
In his most recent research, the most cited papers focused on:
His primary areas of investigation include Stereochemistry, Enzyme, Hydrolase, Nerve agent and Acetylcholinesterase.
His study in Stereochemistry is interdisciplinary in nature, drawing from both Linker, Crystal structure and Cytotoxicity.
His Enzyme research is under the purview of Biochemistry.
His work carried out in the field of Hydrolase brings together such families of science as Enzyme catalysis, Active site, Protein structure, Metal ions in aqueous solution and Histidine.
His work focuses on many connections between Active site and other disciplines, such as Substrate, that overlap with his field of interest in Nanotechnology.
His work on Cyclosarin as part of general Acetylcholinesterase research is frequently linked to GSK-3, bridging the gap between disciplines.
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