World's Best Scientists 2026 revealed!
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Biology and Biochemistry
Israel
2026
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Chemistry
Israel
2026

D-Index & Metrics

Chemistry

D-Index
101
Citations
44592
World Ranking
1203
National Ranking
10

Biology and Biochemistry

D-Index
103
Citations
46264
World Ranking
1299
National Ranking
11

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Israel Leader Award
  • 2026 - Research.com Chemistry in Israel Leader Award
  • 2025 - Research.com Chemistry in Israel Leader Award
  • 2023 - Research.com Chemistry in Israel Leader Award
  • 2022 - Research.com Chemistry in Israel Leader Award
  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Joel L. Sussman is affiliated with the Weizmann Institute of Science in Israel and has contributed to the field of Biochemistry, Genetics, and Molecular Biology through a focus on several specific subfields including Molecular Biology, Pharmacology, Computational Theory and Mathematics, Materials Chemistry, and Cell Biology.

The major research topics addressed in their work include:

  • Cholinesterase and Neurodegenerative Diseases
  • Computational Drug Discovery Methods
  • Protein Structure and Dynamics
  • RNA and protein synthesis mechanisms
  • Enzyme Structure and Function
  • Machine Learning in Bioinformatics
  • Genomics and Phylogenetic Studies

Their recent publications demonstrate a range of structural biology and biochemical studies, including:

  • "A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides," 2020, published in Molecules
  • "IceBear: an intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition," 2021, published in Acta Crystallographica Section D Structural Biology
  • "The future of integrated structural biology," 2024, published in Structure
  • "Structural and Functional Characterization of New SsoPox Variant Points to the Dimer Interface as a Driver for the Increase in Promiscuous Paraoxonase Activity," 2020, published in International Journal of Molecular Sciences
  • "A fish herpesvirus highlights functional diversities among Zα domains related to phase separation induction and A-to-Z conversion," 2022, published in Nucleic Acids Research

The frequent coauthors collaborating with Joel L. Sussman include:

  • Israel Silman (12 joint publications)
  • Orly Dym (5 joint publications)
  • Yacov Ashani (5 joint publications)
  • Tamar Unger (5 joint publications)
  • Shira Albeck (5 joint publications)

The scientist's work is often published in notable venues such as:

  • Acta Crystallographica Section D Structural Biology (3 publications)
  • Protein Science (3 publications)
  • Proteins Structure Function and Bioinformatics (2 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (2 publications)
  • Structure (1 publication)

Joel L. Sussman received recognition as a Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

  • Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein

    Joel L. Sussman;Michal Harel;Felix Frolow;Christian Oefner

  • The α/β hydrolase fold

    David L. Ollis;Eong Cheah;Miroslaw Cygler;Bauke Dijkstra

  • Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

    M Harel;I Schalk;L Ehret-Sabatier;F Bouet

  • FoldIndex©: a simple tool to predict whether a given protein sequence is intrinsically unfolded

    Jaime Prilusky;Clifford E. Felder;Tzviya Zeev-Ben-Mordehai;Edwin H. Rydberg

  • Three-dimensional tertiary structure of yeast phenylalanine transfer RNA.

    S. H. Kim;F. L. Suddath;G. J. Quigley;A. McPherson

  • Function and structure of inherently disordered proteins

    A Keith Dunker;Israel Silman;Vladimir N Uversky;Vladimir N Uversky;Joel L Sussman

  • Protein production and purification.

    S Gräslund

  • Protein Data Bank (PDB): Database of Three-Dimensional Structural Information of Biological Macromolecules

    Joel L. Sussman;Joel L. Sussman;Dawei Lin;Jiansheng Jiang;Nancy O. Manning

  • Acetylcholinesterase: From 3D structure to function

    Hay Dvir;Israel Silman;Michal Harel;Terrone L. Rosenberry

  • Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.

    Gitay Kryger;Israel Silman;Joel L Sussman

  • Three-dimensional structures of avidin and the avidin-biotin complex

    Oded Livnah;Edward A. Bayer;Meir Wilchek;Joel L. Sussman

  • Structure and Evolution of the Serum Paraoxonase Family of Detoxifying and Anti-Atherosclerotic Enzymes

    Michal Harel;Amir Aharoni;Leonid Gaidukov;Boris Brumshtein

  • The pitch of chromatin DNA is reflected in its nucleotide sequence.

    Edward N. Trifonov;Joel L. Sussman

  • Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteins

    Miroslaw Cygler;Joseph D. Schrag;Joel L. Sussman;Michal Harel

  • Acetylcholinesterase: ‘classical’ and ‘non-classical’ functions and pharmacology

    Israel Silman;Joel L Sussman

  • Specific chemical and structural damage to proteins produced by synchrotron radiation.

    Martin Weik;Raimond B. G. Ravelli;Gitay Kryger;Sean McSweeney

  • Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.

    Adi Goldenzweig;Moshe Goldsmith;Shannon E. Hill;Or Gertman

  • Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.

    Mia L. Raves;Michal Harel;Yuan Ping Pang;Israel Silman

  • Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system

    Yoseph Shaaltiel;Daniel Bartfeld;Sharon Hashmueli;Gideon Baum

  • Crystal structure of yeast phenylalanine transfer RNA. I. Crystallographic refinement.

    J L Sussman;S R Holbrook;R W Warrant;G M Church

Frequent Co-Authors

Israel Silman
Israel Silman Weizmann Institute of Science
Michal Harel
Michal Harel Weizmann Institute of Science
Dan S. Tawfik
Dan S. Tawfik Weizmann Institute of Science
Anthony H. Futerman
Anthony H. Futerman Weizmann Institute of Science
Sung-Hou Kim
Sung-Hou Kim University of California, Berkeley
Hualiang Jiang
Hualiang Jiang Chinese Academy of Sciences
Raimond B. G. Ravelli
Raimond B. G. Ravelli Maastricht University
Florian Nachon
Florian Nachon Centre national de la recherche scientifique, CNRS
Felix Frolow
Felix Frolow Tel Aviv University
Jean Massoulié
Jean Massoulié École Normale Supérieure

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