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Ichio Shimada

Ichio Shimada

D-Index & Metrics

Chemistry

D-Index
62
Citations
11347
World Ranking
9008
National Ranking
631

Biology and Biochemistry

D-Index
62
Citations
11082
World Ranking
11001
National Ranking
754

Overview

Ichio Shimada is affiliated with the University of Tokyo in Japan and has contributed extensively in the field of Biochemistry, Genetics and Molecular Biology with a focus on Molecular Biology, Cellular and Molecular Neuroscience, Physiology, Spectroscopy, and Radiology, Nuclear Medicine and Imaging.

The research topics central to Shimada's work include:

  • Receptor Mechanisms and Signaling
  • Protein Structure and Dynamics
  • Glycosylation and Glycoproteins Research
  • Ion channel regulation and function
  • Neuropeptides and Animal Physiology
  • Pharmacological Receptor Mechanisms and Effects
  • Monoclonal and Polyclonal Antibodies Research

Shimada has published multiple papers in well-recognized scientific journals. Recent publications include:

  • "Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties," 2020, Nature Communications
  • "Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis," 2021, Nature Structural & Molecular Biology
  • "Structural equilibrium underlying ligand-dependent activation of β2-adrenoreceptor," 2020, Nature Chemical Biology
  • "Activation of adenosine A 2A receptor by lipids from docosahexaenoic acid revealed by NMR," 2020, Science Advances
  • "Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS," 2020, Cell Reports

Shimada frequently publishes in several venues, with multiple works in:

  • Nature Communications
  • Biological Magnetic Resonance Bank
  • Science Advances
  • Journal of the American Chemical Society
  • bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors collaborating with Shimada include:

  • Shunsuke Imai
  • Takumi Ueda
  • Koh Takeuchi
  • Yutaka Kofuku
  • Yuji Tokunaga

Best Publications

  • Three-dimensional solution structure of the B domain of staphylococcal protein A: comparisons of the solution and crystal structures.

    Hiroaki Gouda;Hidetaka Torigoe;Akiko Saito;Moriyuki Sato

  • A novel NMR method for determining the interfaces of large protein-protein complexes.

    Hideo Takahashi;Tamiji Nakanishi;Keiichiro Kami;Yoji Arata

  • GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures

    Ichio Shimada;Takumi Ueda;Yutaka Kofuku;Matthew T. Eddy

  • Efficacy of the β₂-adrenergic receptor is determined by conformational equilibrium in the transmembrane region.

    Yutaka Kofuku;Takumi Ueda;Junya Okude;Yutaro Shiraishi

  • Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases

    Yuji Funakoshi;Yusuke Doi;Nao Hosoda;Naoyuki Uchida

  • Functional Dynamics of Deuterated β2-Adrenergic Receptor in Lipid Bilayers Revealed by NMR Spectroscopy†

    Yutaka Kofuku;Takumi Ueda;Takumi Ueda;Junya Okude;Yutaro Shiraishi

  • Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4

    Yutaka Kofuku;Chie Yoshiura;Takumi Ueda;Hiroaki Terasawa

  • Identification of neutral and sialyl N-linked oligosaccharide structures from human serum glycoproteins using three kinds of high-performance liquid chromatography.

    H. Nakagawa;Y. Kawamura;K. Kato;I. Shimada

  • Differential N-glycan patterns of secreted and intracellular IgG produced in Trichoplusia ni cells.

    Tsu-An Hsu;Noriko Takahashi;Yoshinori Tsukamoto;Koichi Kato

  • Observation of NMR signals from proteins introduced into living mammalian cells by reversible membrane permeabilization using a pore-forming toxin, streptolysin O.

    Shinji Ogino;Satoshi Kubo;Ryo Umemoto;Shuxian Huang

  • Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins.

    Hideo Takahashi;Jae Il Kim;Hye Jung Min;Kazuki Sato

  • Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor

    Junya Okude;Takumi Ueda;Takumi Ueda;Yutaka Kofuku;Motohiko Sato

  • Structure of melittin bound to perdeuterated dodecylphosphocholine micelles as studied by two-dimensional NMR and distance geometry calculations

    Fuyuhiko Inagaki;Ichio Shimada;Ken Kawaguchi;Masahiko Hirano

  • Determination of the interface of a large protein complex by transferred cross-saturation measurements.

    Tamiji Nakanishi;Mayumi Miyazawa;Masayoshi Sakakura;Hiroaki Terasawa

  • A Gel-Encapsulated Bioreactor System for NMR Studies of Protein–Protein Interactions in Living Mammalian Cells†

    Satoshi Kubo;Noritaka Nishida;Yuko Udagawa;Osamu Takarada

  • Structural basis of the interaction between IgG and Fcgamma receptors.

    Koichi Kato;Catherine Sautès-Fridman;Wakako Yamada;Kaoru Kobayashi

  • Crystallographic and lithium-6 and nitrogen-15 NMR studies of a chiral bidentate lithium amide. An effect of aggregation states on an enantioselective deprotonation reaction

    Daisaku Sato;Hisashi Kawasaki;Ichio Shimada;Yoji Arata

  • Structural basis underlying the dual gate properties of KcsA

    Shunsuke Imai;Masanori Osawa;Koh Takeuchi;Ichio Shimada;Ichio Shimada

  • Pairing of oligosaccharides in the Fc region of immunoglobulin G

    Katsuyoshi Masuda;Yoshiki Yamaguchi;Koichi Kato;Noriko Takahashi

  • Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells.

    Kazuki N. Sugahara;Takako Hirata;Toshiyuki Tanaka;Shinji Ogino

Frequent Co-Authors

Yoji Arata
Yoji Arata University of Tokyo
Koichi Kato
Koichi Kato National Institutes of Natural Sciences
Hideo Takahashi
Hideo Takahashi University of Tokyo
Noriko Takahashi
Noriko Takahashi Nagoya City University
Haruki Nakamura
Haruki Nakamura Osaka University
Kouji Matsushima
Kouji Matsushima Tokyo University of Science
Masayuki Miyasaka
Masayuki Miyasaka Osaka University
Eiko Ohtsuka
Eiko Ohtsuka Hokkaido University
Fuyuhiko Inagaki
Fuyuhiko Inagaki Hokkaido University
Osamu Nureki
Osamu Nureki University of Tokyo

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