What is he best known for?
The fields of study he is best known for:
His primary scientific interests are in Kinase, Biochemistry, Tyrosine kinase, Cancer research and Pharmacology.
The Kinase study combines topics in areas such as Cell culture, Cell cycle and In vivo.
His Tyrosine kinase study combines topics from a wide range of disciplines, such as Chronic myelogenous leukemia, Stereochemistry, Platelet-derived growth factor receptor and Tyrosine phosphorylation.
His Stereochemistry research incorporates themes from Aryl, Peptide and Amide.
His study in Cancer research is interdisciplinary in nature, drawing from both Mutation, Cyclin-dependent kinase, Receptor tyrosine kinase and Immunology.
His Pharmacology research incorporates elements of Imatinib, Transplantation and Drug discovery.
His most cited work include:
- Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity (966 citations)
- In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase (508 citations)
- Protein kinases as targets for anticancer agents: from inhibitors to useful drugs (336 citations)
What are the main themes of his work throughout his whole career to date?
Pascal Furet focuses on Stereochemistry, Kinase, Biochemistry, Tyrosine kinase and Pharmacology.
Pascal Furet has researched Stereochemistry in several fields, including Peptide, Aryl, Alkyl and SH2 domain.
His studies deal with areas such as Cancer research, Signal transduction, Transplantation and In vivo as well as Kinase.
As part of his studies on Biochemistry, he often connects relevant areas like Cell biology.
His Tyrosine kinase study combines topics from a wide range of disciplines, such as Receptor tyrosine kinase, Neoplastic disease, Anthranilic acid and Platelet-derived growth factor receptor.
His research integrates issues of PI3K/AKT/mTOR pathway and Disease in his study of Pharmacology.
He most often published in these fields:
- Stereochemistry (37.28%)
- Kinase (23.99%)
- Biochemistry (23.41%)
What were the highlights of his more recent work (between 2014-2021)?
- Kinase (23.99%)
- Pharmacology (12.43%)
- Stereochemistry (37.28%)
In recent papers he was focusing on the following fields of study:
His primary areas of investigation include Kinase, Pharmacology, Stereochemistry, Cell biology and Cancer research.
His Kinase study is associated with Biochemistry.
His studies in Pharmacology integrate themes in fields like Structure–activity relationship, Cell growth, PI3K/AKT/mTOR pathway, Phosphoinositide 3-kinase and In vivo.
His Stereochemistry research is multidisciplinary, incorporating elements of Phosphatidylinositol and Amide.
His Cancer research research includes elements of Mutation, Cancer, ABL and Bioinformatics.
His ABL research focuses on Chronic myelogenous leukemia and how it connects with Tyrosine kinase.
Between 2014 and 2021, his most popular works were:
- The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1 (186 citations)
- Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma. (185 citations)
- Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. (82 citations)
In his most recent research, the most cited papers focused on:
His main research concerns Pharmacology, Kinase, Cancer research, Cancer and In vivo.
His Pharmacology research incorporates elements of Structure–activity relationship, Transferase and Quinazoline.
His research on Kinase concerns the broader Biochemistry.
His study in Cancer research is interdisciplinary in nature, drawing from both Mutation, Receptor, Signal transduction, Kinome and Drug resistance.
His In vivo research incorporates themes from Autophagy, Phases of clinical research, Phosphoinositide 3-kinase, Bioavailability and Derivative.
His studies examine the connections between Fibroblast growth factor receptor 4 and genetics, as well as such issues in Urea, with regards to Stereochemistry.
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