Wolfgang Froestl

Best Publications

• GABAB-RECEPTOR SUBTYPES ASSEMBLE INTO FUNCTIONAL HETEROMERIC COMPLEXES

  Klemens Kaupmann;Barbara Malitschek;Valerie Schuler;Jakob Heid

  1456
  Citations

• Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.

  Klemens Kaupmann;Katharina Huggel;Jakob Heid;Peter J. Flor

  1255
  Citations

• Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1))

  Valérie Schuler;Christian Lüscher;Christophe Blanchet;Norman Klix

  641
  Citations

• Genetic and Pharmacological Evidence of a Role for GABA B Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior

  Cedric Mombereau;Klemens Kaupmann;Wolfgang Froestl;Gilles Sansig

  443
  Citations

• Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.

  Stephan Urwyler;Johannes Mosbacher;Kurt Lingenhoehl;Jakob Heid

  389
  Citations

• C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.

  Adriana Pagano;Giorgio Rovelli;Johannes Mosbacher;Tania Lohmann;Tania Lohmann

  377
  Citations

• CGP 35348: a centrally active blocker of GABAB receptors.

  H R Olpe;G Karlsson;M F Pozza;F Brugger

  357
  Citations

• Behavioral Characterization of the Novel GABAB Receptor-Positive Modulator GS39783 (N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): Anxiolytic-Like Activity without Side Effects Associated with Baclofen or Benzodiazepines

  John F. Cryan;Peter H. Kelly;Frederique Chaperon;Conrad Gentsch

  306
  Citations

• Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists.

  Froestl W;Mickel Sj;von Sprecher G;Diel Pj

  301
  Citations

• Redistribution of GABAB(1) Protein and Atypical GABAB Responses in GABAB(2)-Deficient Mice

  Martin Gassmann;Hamdy Shaban;Réjan Vigot;Gilles Sansig

  276
  Citations

• N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and Structurally Related Compounds: Novel Allosteric Enhancers of γ-Aminobutyric AcidB Receptor Function

  Stephan Urwyler;Mario F. Pozza;Kurt Lingenhoehl;Johannes Mosbacher

  274
  Citations

• Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.

  Wolfgang Froestl;Stuart J. Mickel;Roger G. Hall;Georg von Sprecher

  265
  Citations

• Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding

  Thierry Galvez;Marie-Laure Parmentier;Cécile Joly;Barbara Malitschek

  253
  Citations

• The effects of GABAB agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat

  Sadhana Patel;Sami Naeem;Adam Kesingland;Wolfgang Froestl

  252
  Citations

• SGS742: the first GABAB receptor antagonist in clinical trials

  Wolfgang Froestl;Michela Gallagher;Helen Jenkins;Annette Madrid

  238
  Citations

• Specific γ-hydroxybutyrate-binding sites but loss of pharmacological effects of γ-hydroxybutyrate in GABAB(1)-deficient mice

  Klemens Kaupmann;John F. Cryan;Petrine Wellendorph;Cedric Mombereau

  221
  Citations

• Human γ-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels

  Klemens Kaupmann;Valerie Schuler;Johannes Mosbacher;Serge Bischoff

  212
  Citations

• Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase.

  Boris M. Hogema;Boris M. Hogema;Boris M. Hogema;Maneesh Gupta;Henry Senephansiri;Terry G. Burlingame

  211
  Citations

• The GABAB receptor agonists baclofen and CGP44532 decreased nicotine self-administration in the rat.

  Neil E. Paterson;Wolfgang Froestl;Athina Markou

  192
  Citations

• Mapping the Agonist-binding Site of GABAB Type 1 Subunit Sheds Light on the Activation Process of GABABReceptors

  Thierry Galvez;Laurent Prézeau;Gérald Milioti;Miloslav Franek;Miloslav Franek

  165
  Citations