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Chemistry

D-Index
57
Citations
27431
World Ranking
10909
National Ranking
615

Overview

Geerten W. Vuister is affiliated with the University of Leicester in the United Kingdom and primarily works within the fields of biochemistry, genetics, and molecular biology. Their research spans several interconnected subfields, including molecular biology, spectroscopy, nuclear and high energy physics, materials chemistry, and computational theory and mathematics.

Their scientific output includes fifteen publications in biochemistry, genetics, and molecular biology with a strong focus on protein structure and dynamics, which accounts for fourteen of these works. Other prominent topics in their research are metabolomics and mass spectrometry studies, NMR spectroscopy and its applications, advanced NMR techniques, enzyme structure and function, computational drug discovery methods, and pharmacogenetics and drug metabolism.

Geerten W. Vuister has contributed to several papers notable for their appearance in respected publication venues. These include:

  • Fragment-Based Drug Discovery by NMR. Where Are the Successes and Where can It Be Improved? (2022), Frontiers in Molecular Biosciences
  • CcpNmr AnalysisScreen, a new software programme with dedicated automated analysis tools for fragment-based drug discovery by NMR (2020), Journal of Biomolecular NMR
  • Biochemistry and pathophysiology of the Transient Potential Receptor Vanilloid 6 (TRPV6) calcium channel (2023), Advances in Clinical Chemistry
  • Protein NMR assignment by isotope pattern recognition (2024), Science Advances
  • Restraint validation of biomolecular structures determined by NMR in the Protein Data Bank (2024), Structure

The venues where Vuister has published multiple times include the Journal of Biomolecular NMR and bioRxiv (Cold Spring Harbor Laboratory), among others.

Collaboration plays a significant role in their research, with frequent co-authors including Eliza Płoskoń, Luca Mureddu, Kumaran Baskaran, Roberto Tejero, and Masashi Yokochi. These collaborations point to a network of researchers working in related domains of NMR spectroscopy and molecular biology.

Their research activities involve a strong focus on NMR spectroscopy and fragment-based drug discovery methods, as evidenced by their work on software development for automated analysis in NMR and studies on protein assignments via isotope patterns.

Best Publications

  • NMRPipe: a multidimensional spectral processing system based on UNIX pipes

    Frank Delaglio;Stephan Grzesiek;Geerten W. Vuister;Guang Zhu

  • Quantitative J correlation: a new approach for measuring homonuclear three-bond J(HNH.alpha.) coupling constants in 15N-enriched proteins

    Geerten W. Vuister;Ad Bax

  • Resolution enhancement and spectral editing of uniformly 13C-enriched proteins by homonuclear broadband 13C decoupling

    Geerten W Vuister;Ad Bax

  • CcpNmr AnalysisAssign: a flexible platform for integrated NMR analysis

    Simon P. Skinner;Rasmus H. Fogh;Wayne Boucher;Timothy J. Ragan

  • Measurement of homo- and heteronuclear J couplings from quantitative J correlation

    Ad Bax;Geerten W Vuister;Stephan Grzesiek;Frank Delaglio

  • Gradient-enhanced heteronuclear correlation spectroscopy: Theory and experimental aspects

    Jesús Ruiz-Cabello;Geerten W. Vuister;Chrit T.W. Moonen;Peter van Gelderen

  • Increased Resolution and Improved Spectral Quality in Four-Dimensional 13C/13C-Separated HMQC-NOESY-HMQC Spectra Using Pulsed Field Gradients

    G.W. Vuister;G.M. Clore;A.M. Gronenborn;R. Powers

  • Ca2+ regulation in the Na+/Ca2+ exchanger involves two markedly different Ca2+ sensors

    Mark Hilge;Jan Aelen;Geerten W. Vuister

  • Structural and dynamic changes of photoactive yellow protein during its photocycle in solution.

    Gilles Rubinstenn;Geerten W. Vuister;Geerten W. Vuister;Frans A. A. Mulder;Petra E. Düx

  • WeNMR: Structural Biology on the Grid

    Tsjerk A. Wassenaar;Marc Dijk;Nuno Loureiro-Ferreira;Gijs Schot

  • Measurement of three-bond nitrogen-carbon J couplings in proteins uniformly enriched in nitrogen-15 and carbon-13

    Geerten W. Vuister;Andy C. Wang;Ad Bax

  • The Solution Structure and DNA-binding Properties of the Cold-shock Domain of the Human Y-box Protein YB-1

    Cathelijne P.A.M. Kloks;Christian A.E.M. Spronk;Edwin Lasonder;Astrid Hoffmann

  • Nonselective three-dimensional nmr spectroscopy. The 3D NOE-HOHAHA experiment

    G.W Vuister;R Boelens;R Kaptein

  • Recommendations of the wwPDB NMR Validation Task Force.

    Gaetano T. Montelione;Michael Nilges;Michael Nilges;Ad Bax;Peter Güntert

  • Solution structure and backbone dynamics of the photoactive yellow protein.

    Petra Düx;Gilles Rubinstenn;Geerten W. Vuister;Rolf Boelens

  • Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor.

    Geerten W. Vuister;Soon-Jong Kim;András Orosz;John Marquardt

  • The impact of direct refinement against three-bond HN-CαH coupling constants on protein structure determination by NMR

    D.S. Garrett;J. Kuszewski;T.J. Hancock;P.J. Lodi

  • Gradient-enhanced HMQC and HSQC spectroscopy. Applications to 15N-labeled Mnt repressor

    Geerten W. Vuister;Rolf Boelens;Robert Kaptein;Ralph E. Hurd

  • A simple and sensitive experiment for measurement of JCC couplings between backbone carbonyl and methyl carbons in isotopically enriched proteins.

    Stephan Grzesiek;Geerten W. Vuister;Ad Bax

  • 2D and 3D NMR Study of Phenylalanine Residues in Proteins by Reverse Isotopic Labeling

    Geerten W. Vuister;Soon-Jong Kim;Carl Wu;Ad Bax

  • A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency

    Falk Duchardt;Ivo R. Ruttekolk;Wouter P.R. Verdurmen;Hugues Lortat-Jacob

  • CING: an integrated residue-based structure validation program suite

    Jurgen F. Doreleijers;Alan W. Sousa da Silva;Elmar Krieger;Sander B. Nabuurs

Frequent Co-Authors

Rolf Boelens
Rolf Boelens Utrecht University
Robert Kaptein
Robert Kaptein Utrecht University
Ad Bax
Ad Bax National Institutes of Health
Wim F. Vranken
Wim F. Vranken Vrije Universiteit Brussel
Stephan Grzesiek
Stephan Grzesiek University of Basel
Peter Güntert
Peter Güntert ETH Zurich
Gaetano T. Montelione
Gaetano T. Montelione Rensselaer Polytechnic Institute
Alexandre M. J. J. Bonvin
Alexandre M. J. J. Bonvin Utrecht University
John L. Markley
John L. Markley University of Wisconsin–Madison
Gerard J. Kleywegt
Gerard J. Kleywegt European Bioinformatics Institute

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