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Biology and Biochemistry

D-Index
58
Citations
8240
World Ranking
13479
National Ranking
5719

Overview

Janet D. Klein is affiliated with Emory University in the United States. Their research spans several areas within the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on molecular and physiological mechanisms related to renal function and muscle physiology.

The primary research topics covered by Klein include:

  • Ion Transport and Channel Regulation
  • Electrolyte and hormonal disorders
  • Muscle Physiology and Disorders
  • Thermoregulation and physiological responses
  • Neuroendocrine regulation and behavior
  • Extracellular vesicles in disease
  • Peripheral Artery Disease Management

The scientist has contributed to subfields such as Molecular Biology, Pulmonary and Respiratory Medicine, Physiology, Surgery, and Nephrology. Their frequent publication venues further reflect these interests and include:

  • The FASEB Journal
  • Cells
  • American Journal of Physiology-Renal Physiology
  • Journal of Cachexia Sarcopenia and Muscle
  • Acta Physiologica

Klein's recent papers document specific investigations into muscle wasting, kidney disease, and physiological regulation. Notable publications include:

  • The impact of senescence on muscle wasting in chronic kidney disease, 2022, Journal of Cachexia Sarcopenia and Muscle
  • Adaptive physiological water conservation explains hypertension and muscle catabolism in experimental chronic renal failure, 2021, Acta Physiologica
  • Exogenous miR-29a Attenuates Muscle Atrophy and Kidney Fibrosis in Unilateral Ureteral Obstruction Mice, 2020, Human Gene Therapy
  • Inhibition of urea transporter ameliorates uremic cardiomyopathy in chronic kidney disease, 2020, The FASEB Journal
  • Adrenomedullin Inhibits Osmotic Water Permeability in Rat Inner Medullary Collecting Ducts, 2020, Cells

Throughout their career, Klein has frequently collaborated with other researchers including Jeff M. Sands, Xiaonan H. Wang, Faten Hassounah, Eva L. Rodriguez, and Yanhua Wang. These collaborations reflect interdisciplinary investigations within kidney physiology, muscle disorders, and related molecular pathways.

The body of work by Janet D. Klein provides insights into physiological processes at the molecular and systemic levels, especially relevant to conditions such as chronic kidney disease and muscle atrophy. Their research integrates aspects of molecular biology with clinical physiological outcomes, emphasizing mechanisms of ion transport, hormonal regulation, and cellular responses in health and disease.

Best Publications

  • High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation

    Kento Kitada;Steffen Daub;Yahua Zhang;Janet D. Klein

  • Glucocorticoids downregulate the vasopressin-regulated urea transporter in rat terminal inner medullary collecting ducts.

    M Naruse;J D Klein;Z M Ashkar;J D Jacobs

  • Cloning and Characterization of Two New Isoforms of the Rat Kidney Urea Transporter UT-A3 and UT-A4

    Alexander Karakashian;Richard T. Timmer;Janet D. Klein;Robert B. Gunn

  • Exosome-Mediated miR-29 Transfer Reduces Muscle Atrophy and Kidney Fibrosis in Mice.

    Haidong Wang;Haidong Wang;Bin Wang;Bin Wang;Aiqing Zhang;Aiqing Zhang;Faten Hassounah

  • miRNA-23a/27a attenuates muscle atrophy and renal fibrosis through muscle-kidney crosstalk.

    Aiqing Zhang;Aiqing Zhang;Min Li;Bin Wang;Bin Wang;Janet D. Klein

  • Exercise ameliorates chronic kidney disease–induced defects in muscle protein metabolism and progenitor cell function

    Xiaonan H. Wang;Jie Du;Janet D. Klein;James L. Bailey

  • miR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease.

    Bin Wang;Aiqing Zhang;Haidong Wang;Janet D. Klein

  • Changes in aquaporin-2 protein contribute to the urine concentrating defect in rats fed a low-protein diet.

    J M Sands;M Naruse;J D Jacobs;J N Wilcox

  • Localization of the urea transporter UT-B protein in human and rat erythrocytes and tissues

    Richard T. Timmer;Janet D. Klein;Serena M. Bagnasco;John J. Doran

  • Vasopressin rapidly increases phosphorylation of UT-A1 urea transporter in rat IMCDs through PKA

    Chi Zhang;Jeff M. Sands;Janet D. Klein

  • Volume-sensitive myosin phosphorylation in vascular endothelial cells: correlation with Na-K-2Cl cotransport.

    J. D. Klein;W. C. O'Neill

  • Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation

    Mitsi A. Blount;Abinash C. Mistry;Otto Fröhlich;S. Russ Price

  • Changes in renal medullary transport proteins during uncontrolled diabetes mellitus in rats.

    Dongun Kim;Jeff M. Sands;Janet D. Klein

  • The angiotensin II AT1 receptor is tyrosine and serine phosphorylated and can serve as a substrate for the src family of tyrosine kinases.

    William G. Paxton;Mario B. Marrero;Janet D. Klein;Patrick Delafontaine

  • JNK is a volume-sensitive kinase that phosphorylates the Na-K-2Cl cotransporter in vitro.

    J D Klein;S T Lamitina;W C O'Neill

  • Vasopressin Increases Plasma Membrane Accumulation of Urea Transporter UT-A1 in Rat Inner Medullary Collecting Ducts

    Janet D. Klein;Otto Fröhlich;Mitsi A. Blount;Christopher F. Martin

  • Glucocorticoids mediate a decrease in AVP-regulated urea transporter in diabetic rat inner medulla

    Janet D. Klein;S. Russ Price;James L. Bailey;Joely D. Jacobs

  • 97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation.

    Ako D. Bradford;James M. Terris;James M. Terris;Carolyn A. Ecelbarger;Janet D. Klein

  • Forskolin stimulates phosphorylation and membrane accumulation of UT-A3.

    Mitsi A. Blount;Janet D. Klein;Christopher F. Martin;Dmitry Tchapyjnikov

  • Down-regulation of urea transporters in the renal inner medulla of lithium-fed rats

    Janet D. Klein;Robert B. Gunn;Brian R. Roberts;Jeff M. Sands

Frequent Co-Authors

Jie Du
Jie Du Capital Medical University
Baoxue Yang
Baoxue Yang Peking University
Douglas C. Eaton
Douglas C. Eaton Emory University
Friedrich C. Luft
Friedrich C. Luft Charité - University Medicine Berlin
Akira Nishiyama
Akira Nishiyama Kagawa University
Haian Fu
Haian Fu Emory University
Kenneth E. Bernstein
Kenneth E. Bernstein Cedars-Sinai Medical Center
Mark A. Knepper
Mark A. Knepper National Institutes of Health
R. Clinton Webb
R. Clinton Webb Augusta University
Matthew J.A. Wood
Matthew J.A. Wood University of Oxford

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