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Chemistry

D-Index
42
Citations
6057
World Ranking
17572
National Ranking
4294

Overview

Lucy Waskell is affiliated with the University of Michigan-Ann Arbor in the United States. Their research spans multiple fields, focusing primarily on chemistry, pharmacology, toxicology and pharmaceutics, and medicine. Key subfields include pharmacology, spectroscopy, computational theory and mathematics, endocrinology, diabetes and metabolism, and materials chemistry.

The scientist's work covers a variety of topics, particularly in pharmacogenetics and drug metabolism, computational drug discovery methods, mass spectrometry techniques and applications, advanced proteomics techniques and applications, enzyme structure and function, drug transport and resistance mechanisms, and metal-catalyzed oxygenation mechanisms.

Waskell's recent publications consist of the following papers:

  • Expression, purification, and functional reconstitution of 19F-labeled cytochrome b5 in peptide nanodiscs for NMR studies, 2020, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • A flexible linker of 8-amino acids between the membrane binding segment and the FMN domain of cytochrome P450 reductase is necessary for optimal activity, 2024, Journal of Inorganic Biochemistry
  • The FMN "140s Loop" of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450, 2021, International Journal of Molecular Sciences
  • Similar Rates of Second Electron Transfer and Single-Turnover Dehydroepiandrosterone Formation for Oxyferrous Human Cytochrome P450 17A1 (Steroid 17-Hydroxylase/17,20-lyase)-17-hydroxypregnenolone Complex with Either Human Cytochrome P450-Oxidoreductase or Human Cytochrome b5, 2025, Biochemistry

Waskell frequently collaborates with other researchers in their field. Frequent coauthors include Sang-Choul Im, Freeborn Rwere, Jia Bai, Jian Wang, and Thirupathi Ravula.

The main venues where their work has been published are:

  • Biochimica et Biophysica Acta (BBA) - Biomembranes
  • Journal of Inorganic Biochemistry
  • International Journal of Molecular Sciences
  • Biochemistry

Best Publications

  • The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin.

    Thomas A. Clarke;Lucy A. Waskell

  • Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase.

    Angela Bridges;Larry Gruenke;Yan-Tyng Chang;Ilya A. Vakser

  • Structure and Function of an NADPH-Cytochrome P450 Oxidoreductase in an Open Conformation Capable of Reducing Cytochrome P450

    Djemel Hamdane;Chuanwu Xia;Sang Choul Im;Haoming Zhang

  • Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation.

    Jason J. Cournoyer;Jason L. Pittman;Vera B. Ivleva;Eric Fallows

  • The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b5

    Sang Choul Im;Lucy Waskell

  • Solid-state NMR reveals structural and dynamical properties of a membrane-anchored electron-carrier protein, cytochrome b5.

    Ulrich H N Dürr;Kazutoshi Yamamoto;Sang Choul Im;Lucy Waskell

  • The cytochromes P450 and b5 and their reductases--promising targets for structural studies by advanced solid-state NMR spectroscopy.

    Ulrich H.N. Dürr;Lucy Waskell;Lucy Waskell;Ayyalusamy Ramamoorthy

  • Cytochrome b5, its functions, structure and membrane topology

    Unknown

  • Conformational changes of NADPH-cytochrome P450 oxidoreductase are essential for catalysis and cofactor binding.

    Chuanwu Xia;Djemel Hamdane;Anna L. Shen;Vivian Choi

  • Cytochrome b5 increases the rate of product formation by cytochrome P450 2B4 and competes with cytochrome P450 reductase for a binding site on cytochrome P450 2B4

    Haoming Zhang;Sang Choul Im;Lucy Waskell

  • A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data

    Shivani Ahuja;Nicole Jahr;Sang Choul Im;Subramanian Vivekanandan

  • Cellular solid-state NMR investigation of a membrane protein using dynamic nuclear polarization.

    Kazutoshi Yamamoto;Marc A. Caporini;Sang Choul Im;Lucy Waskell

  • High-Level Expression in Escherichia coli and Purification of the Membrane-Bound Form of Cytochrome b5

    Scott B. Mulrooney;Lucy Waskell;Lucy Waskell

  • Cytochrome b5 inhibits electron transfer from NADPH-cytochrome P450 reductase to ferric cytochrome P450 2B4.

    Haoming Zhang;Djemel Hamdane;Sang Choul Im;Lucy Waskell

  • Role of cytochrome b5 in catalysis by cytochrome P450 2B4.

    Haoming Zhang;Eugene Myshkin;Eugene Myshkin;Lucy Waskell;Lucy Waskell

  • Reconstitution of the Cytb5–CytP450 Complex in Nanodiscs for Structural Studies using NMR Spectroscopy

    Meng Zhang;Rui Huang;Rose Ackermann;Sang Choul Im

  • Studies on the photosensitized breakdown of guanosine by methylene blue

    Lucy A. Waskell;K.Sivarama Sastry;Milton P. Gordon

  • Theoretical study of the ligand-CYP2B4 complexes: effect of structure on binding free energies and heme spin state.

    Danni L. Harris;Jin Young Park;Larry Gruenke;Lucy Waskell

  • Dynamic interaction between membrane-bound full-length cytochrome P450 and cytochrome b5 observed by solid-state NMR spectroscopy.

    Kazutoshi Yamamoto;Ulrich H.N. Dürr;Jiadi Xu;Sang Choul Im

  • Probing the Transmembrane Structure and Topology of Microsomal Cytochrome-P450 by Solid-State NMR on Temperature-Resistant Bicelles

    Kazutoshi Yamamoto;Melissa Gildenberg;Shivani Ahuja;Sang Choul Im

  • Structure and Spectra of Ferrous Dioxygen and Reduced Ferrous Dioxygen Model Cytochrome P450

    Unknown

  • Calculation of the electronic structure and spectra of model cytochrome P450 compound I.

    Dan Harris;Gilda Loew;Lucy Waskell

  • Mutation of tyrosine 190 to alanine eliminates the inactivation of cytochrome P450 2B1 by peroxynitrite.

    Hsia lien Lin;Ute M. Kent;Haoming Zhang;Lucy Waskell

Frequent Co-Authors

Ayyalusamy Ramamoorthy
Ayyalusamy Ramamoorthy Florida State University
Paul F. Hollenberg
Paul F. Hollenberg University of Michigan–Ann Arbor
G. M. Anantharamaiah
G. M. Anantharamaiah University of Alabama at Birmingham
Jung-Ja P. Kim
Jung-Ja P. Kim Medical College of Wisconsin
Dennis J. Stuehr
Dennis J. Stuehr Cleveland Clinic Lerner College of Medicine
James R. Kincaid
James R. Kincaid Marquette University
Erik R. P. Zuiderweg
Erik R. P. Zuiderweg University of Michigan–Ann Arbor
Sason Shaik
Sason Shaik Hebrew University of Jerusalem
Jeanne A. Stuckey
Jeanne A. Stuckey University of Michigan–Ann Arbor
Zhan Chen
Zhan Chen University of Michigan–Ann Arbor

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