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Chemistry

D-Index
51
Citations
7403
World Ranking
14169
National Ranking
3658

Overview

James R. Kincaid was affiliated with Marquette University in the United States. Their research primarily focused on biochemistry, genetics, and molecular biology, with notable contributions in pharmacology, endocrinology, diabetes and metabolism, molecular biology, inorganic chemistry, and cell biology.

Their work covered a range of topics including pharmacogenetics and drug metabolism, metal-catalyzed oxygenation mechanisms, hormonal regulation and hypertension, hormonal and reproductive studies, hemoglobin structure and function, protein structure and dynamics, and mass spectrometry techniques and applications.

James R. Kincaid published multiple papers in various scientific journals. Selected recent papers include:

  • Substrate-Specific Allosteric Effects on the Enhancement of CYP17A1 Lyase Efficiency by Cytochrome b5, 2021, Journal of the American Chemical Society
  • Heme-Edge Residues Modulate Signal Transduction within a Bifunctional Homo-Dimeric Sensor Protein, 2021, Biochemistry
  • P450 CYP17A1 Variant with a Disordered Proton Shuttle Assembly Retains Peroxo-Mediated Lyase Efficiency, 2020, Chemistry - A European Journal
  • Resonance Raman studies of gas sensing heme proteins, 2021, Journal of Raman Spectroscopy
  • Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A1, 2021, Biochemistry

Kincaid's frequent co-authors were Yilin Liu, Ilia G. Denisov, Stephen G. Sligar, Remigio Usai, and Laurence A. Nafié. Collaboration across these researchers indicated engagement with complex biochemical and molecular processes, often linking protein dynamics and enzymatic mechanisms.

The venues that published Kincaid's research most frequently included:

  • Journal of Inorganic Biochemistry
  • Journal of Raman Spectroscopy
  • Biochemistry
  • Dickens Studies Annual
  • Journal of the American Chemical Society

James R. Kincaid contributed primarily to the study of biochemical processes related to enzyme function and regulation, notably in the area of cytochrome P450 enzymes. Their research involved detailed molecular investigations using techniques such as resonance Raman spectroscopy and mass spectrometry, with implications for understanding drug metabolism and hormonal regulation.

Best Publications

  • Consistent porphyrin force field. 1. Normal-mode analysis for nickel porphine and nickel tetraphenylporphine from resonance Raman and infrared spectra and isotope shifts

    Xiao Yuan. Li;Roman S. Czernuszewicz;James R. Kincaid;Y. Oliver. Su

  • Consistent porphyrin force field. 2. Nickel octaethylporphyrin skeletal and substituent mode assignments from nitrogen-15, meso-d4, and methylene-d16 Raman and infrared isotope shifts

    Xiaoyuan Li;Roman S. Czernuszewicz;James Robert Kincaid;Paul B. Stein

  • Vibrational spectra and normal-coordinate analysis of tris(bipyridine)ruthenium(II)

    Prabal K. Mallick;Gerald D. Danzer;Dennis P. Strommen;James R. Kincaid

  • Consistent porphyrin force field. 3. Out-of-plane modes in the resonance Raman spectra of planar and ruffled nickel octaethylporphyrin

    Xiaoyuan Li;Roman S. Czernuszewicz;James Robert Kincaid;Thomas G. Spiro

  • Normal-coordinate analyses of the ground and 3MLCT excited states of tris(bipyridine)ruthenium(II)

    Dennis P. Strommen;Prabal K. Mallick;Gerald D. Danzer;Richard S. Lumpkin

  • Structure-sensitive resonance Raman bands of tetraphenyl and "picket fence" porphyrin-iron complexes, including an oxyhemoglobin analog

    J. M. Burke;J. R. Kincaid;S. Peters;R. R. Gagne

  • Resonance Raman spectroscopy reveals a1u vs. a2u character and pseudo-Jahn-Teller distortion in radical cations of nickel(II), copper(II), and chloroiron(III) octaethyl- and tetraphenylporphyrins

    Roman S. Czernuszewicz;Kathleen A. Macor;Xiaoyuan Li;James Robert Kincaid

  • Resonance Raman spectra and vibrational modes of iron(III) tetraphenylporphine .mu.-oxo dimer. Evidence for phenyl interaction and lack of dimer splitting

    J. M. Burke;J. R. Kincaid;T. G. Spiro

  • Zeolite-entrapped ruthenium(II) complexes with bipyridine and related ligands. Elimination of ligand-field-state deactivation and increase in 3MLCT state lifetimes

    Krzysztof Maruszewski;Dennis P. Strommen;James R. Kincaid

  • Photochemical energy storage in a spatially organized zeolite-based photoredox system

    Milan Sykora;James R. Kincaid

  • Synthesis and far-infrared spectra of ferric octaethylporphine complexes

    H. Ogoshi;E. Watanbe;Z. Yoshida;J. Kincaid

  • Mixed-ligand poly(pyridine) complexes of ruthenium(II). Resonance Raman spectroscopic evidence for selective population of ligand-localized 3MLCT excited states

    Stephen F. McClanahan;Richard F. Dallinger;F. James Holler;James R. Kincaid

  • Direct Resonance Raman Evidence for a Trans Influence on the Ferryl Fragment in Models of Compound I Intermediates of Heme Enzymes

    Kazimierz Czarnecki;Shay Nimri;Zeev Gross;Leonard M. Proniewicz,†,§ and

  • Resonance Raman spectra and excitation profiles of tris(.alpha.-diimine) complexes of iron(II)

    R. J. H. Clark;P. C. Turtle;D. P. Strommen;B. Streusand

  • Resonance Raman characterization of nitric oxide adducts of cytochrome P450cam : the effect of substrate structure on the iron-ligand vibrations

    Songzhou Hu;James R. Kincaid

  • Resonance Raman characterization of the peroxo and hydroperoxo intermediates in cytochrome P450

    Ilia G. Denisov;Piotr J. Mak;Thomas M. Makris;Stephen G. Sligar

  • Position-Dependent Deuteration Effects on the Nonradiative Decay of the 3MLCT State of Tris(bipyridine)ruthenium (II). An Experimental Evaluation of Radiationless Transition Theory

    Krzysztof Maruszewski;Krzysztof Bajdor;Dennis P. Strommen;James R. Kincaid

  • Dramatic Increase of 3MLCT State Lifetimes of a Ruthenium(II) Polypyridine Complex upon Entrapment within Y-Zeolite Supercages

    Krzysztof Maruszewski;James R. Kincaid

  • Structure sensitive bands in the vibrational spectra of metal complexes of tetraphenylporphine

    Hiroki Oshio;Tomoharu Ama;Takeshi Watanabe;James Kincaid

  • Unveiling the crucial intermediates in androgen production.

    Piotr J. Mak;Michael C. Gregory;Ilia G. Denisov;Stephen G. Sligar

  • Resonance raman studies of oxycytochrome P450cam: effect of substrate structure on .nu.(O-O) and .nu.(Fe-O2)

    Songzhou Hu;Andrew J. Schneider;James R. Kincaid

Frequent Co-Authors

Stephen G. Sligar
Stephen G. Sligar University of Illinois at Urbana-Champaign
Thomas G. Spiro
Thomas G. Spiro University of Washington
Ilia G. Denisov
Ilia G. Denisov University of Illinois at Urbana-Champaign
Xiaoyuan Li
Xiaoyuan Li Yale University
Kazuo Nakamoto
Kazuo Nakamoto Marquette University
David H. Petering
David H. Petering University of Wisconsin–Milwaukee
Lucy Waskell
Lucy Waskell University of Michigan–Ann Arbor
Victor Guallar
Victor Guallar Barcelona Supercomputing Center
Andrew W. Munro
Andrew W. Munro University of Manchester
Paul F. Hollenberg
Paul F. Hollenberg University of Michigan–Ann Arbor

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