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Chemistry

D-Index
115
Citations
51808
World Ranking
631
National Ranking
266

Research.com Recognitions

  • 1993 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Stephen G. Sligar is affiliated with the University of Illinois at Urbana-Champaign in the United States. Their research intersects multiple areas within biochemistry, molecular biology, and medicine, focusing on topics such as pharmacogenetics, lipid membrane behavior, and metal-catalyzed oxygenation mechanisms.

The main fields of study for this scientist include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broader fields, their work spans several subfields, notably:

  • Molecular Biology
  • Pharmacology
  • Endocrinology, Diabetes and Metabolism
  • Inorganic Chemistry
  • Radiology, Nuclear Medicine and Imaging

Their research covers key topics, including:

  • Pharmacogenetics and Drug Metabolism
  • Lipid Membrane Structure and Behavior
  • Metal-Catalyzed Oxygenation Mechanisms
  • Hormonal Regulation and Hypertension
  • Hormonal and reproductive studies
  • Supramolecular Self-Assembly in Materials
  • Protein Kinase Regulation and GTPase Signaling

Stephen G. Sligar has contributed to publications in several scientific venues, with frequent appearances in:

  • Biochemistry
  • Journal of Inorganic Biochemistry
  • Journal of the American Chemical Society
  • Biophysical Journal
  • Protein Science

Notable recent papers include:

  • "Nanodiscs: A toolkit for membrane protein science" (2020) published in Protein Science
  • "Midazolam as a Probe for Drug-Drug Interactions Mediated by CYP3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation" (2021) published in Biochemistry
  • "Antibody Targeted PET Imaging of 64Cu-DOTA-Anti-CEA PEGylated Lipid Nanodiscs in CEA Positive Tumors" (2020) published in Bioconjugate Chemistry
  • "Engineering C-C Bond Cleavage Activity into a P450 Monooxygenase Enzyme" (2023) published in Journal of the American Chemical Society
  • "Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by CYP3A4" (2022) published in Biomolecules

The scientist has collaborated frequently with coauthors including Ilia G. Denisov, Mark A. McLean, Yelena V. Grinkova, James R. Kincaid, and Tyler Camp.

Stephen G. Sligar was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 1993.

Best Publications

  • The energy landscapes and motions of proteins.

    Hans Frauenfelder;Stephen G. Sligar;Peter G. Wolynes

  • Structure and Chemistry of Cytochrome P450

    Ilia G. Denisov;Thomas M. Makris;Stephen G. Sligar;Ilme Schlichting

  • Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

    Carsten Grashoff;Brenton D. Hoffman;Michael D. Brenner;Ruobo Zhou

  • The Catalytic Pathway of Cytochrome P450Cam at Atomic Resolution

    Ilme Schlichting;Joel Berendzen;Kelvin Chu;Kelvin Chu;Ann M. Stock

  • Directed self-assembly of monodisperse phospholipid bilayer Nanodiscs with controlled size.

    Ilia G Denisov;Yelena V Grinkova;A A Lazarides;Stephen G Sligar

  • Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs.

    T. K. Ritchie;Y. V. Grinkova;T. H. Bayburt;I. G. Denisov

  • Self-Assembly of Discoidal Phospholipid Bilayer Nanoparticles with Membrane Scaffold Proteins

    Timothy H. Bayburt;Yelena V. Grinkova;Stephen G. Sligar

  • Mechanisms of Ligand Recognition in Myoglobin

    Barry A. Springer;Stephen G. Sligar;John S. Olson;George N. Jr. Phillips

  • Membrane protein assembly into Nanodiscs

    Timothy H. Bayburt;Stephen G. Sligar

  • Coupling of spin, substrate, and redox equilibria in cytochrome P450.

    Stephen G. Sligar

  • Applications of phospholipid bilayer nanodiscs in the study of membranes and membrane proteins.

    Abhinav Nath;William M. Atkins;Stephen G. Sligar

  • Nanodiscs for structural and functional studies of membrane proteins

    Ilia G Denisov;Stephen G Sligar

  • Hydroxylation of camphor by reduced oxy-cytochrome P450cam: mechanistic implications of EPR and ENDOR studies of catalytic intermediates in native and mutant enzymes.

    Roman Davydov;Thomas M. Makris;Victoria Kofman;David E. Werst

  • Nanodiscs in Membrane Biochemistry and Biophysics

    Ilia G. Denisov;Stephen G. Sligar

  • High-level expression of sperm whale myoglobin in Escherichia coli

    Barry A. Springer;Stephen G. Sligar

  • Sizing DNA using a nanometer-diameter pore.

    Jiunn B. Heng;Chuen Ho;Taekyung Kim;Rolf Timp

  • Transducin Activation by Nanoscale Lipid Bilayers Containing One and Two Rhodopsins

    Timothy H. Bayburt;Andrew J. Leitz;Guifu Xie;Daniel D. Oprian

  • Self-assembly of single integral membrane proteins into soluble nanoscale phospholipid bilayers

    Timothy H. Bayburt;Stephen G. Sligar;Stephen G. Sligar

  • A thermodynamic model of regulation: modulation of redox equilibria in camphor monoxygenase.

    Stephen G. Sligar;I. C. Gunsalus

  • Discrimination between oxygen and carbon monoxide and inhibition of autooxidation by myoglobin. Site-directed mutagenesis of the distal histidine.

    B. A. Springer;K. D. Egeberg;Stephen G. Sligar;R. J. Rohlfs

Frequent Co-Authors

Ilia G. Denisov
Ilia G. Denisov University of Illinois at Urbana-Champaign
James R. Kincaid
James R. Kincaid Marquette University
Irwin C. Gunsalus
Irwin C. Gunsalus University of Illinois at Urbana-Champaign
Klaus Schulten
Klaus Schulten University of Illinois at Urbana-Champaign
Thomas L. Poulos
Thomas L. Poulos University of California, Irvine
Patrick S. Stayton
Patrick S. Stayton University of Washington
Mary A. Schuler
Mary A. Schuler University of Illinois at Urbana-Champaign
John B. Schenkman
John B. Schenkman University of Connecticut Health Center
Gerd N. La Mar
Gerd N. La Mar University of California, Davis
John S. Olson
John S. Olson Rice University

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