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Biology and Biochemistry

D-Index
65
Citations
16292
World Ranking
9093
National Ranking
698

Research.com Recognitions

  • 2006 - Fellow of the Royal Society, United Kingdom

Overview

Matthew Freeman is a researcher affiliated with the University of Oxford in the United Kingdom. Their academic contributions primarily span the fields of biochemistry, genetics, molecular biology, and medicine. They have published extensively in molecular biology and cell biology, with additional work involving oncology, physiology, and ecology.

The main topics covered by Freeman's research include endoplasmic reticulum stress and disease, peatlands and wetlands ecology, bioinformatics and genomic networks, ubiquitin and proteasome pathways, CRISPR and genetic engineering, peptidase inhibition and analysis, and HER2/EGFR in cancer research.

Freeman's publication record features frequent appearances in venues such as bioRxiv (Cold Spring Harbor Laboratory), ECS Meeting Abstracts, Molecular Cell, Journal of Biological Chemistry, and The EMBO Journal. Their research collaborations often involve coauthors like Clémence Levet, Adam G. Grieve, Fangfang Lu, Iqbal Dulloo, and O. Claire Moulton.

Selected recent papers include:

  • Mechanism-based traps enable protease and hydrolase substrate discovery, 2022, Nature
  • Functional unknomics: Systematic screening of conserved genes of unknown function, 2023, PLoS Biology
  • Bacterial rhomboid proteases mediate quality control of orphan membrane proteins, 2020, The EMBO Journal
  • ADAM 17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration, 2020, The EMBO Journal
  • The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release, 2021, Cellular and Molecular Life Sciences

Matthew Freeman was recognized with the title of Fellow of the Royal Society, United Kingdom, awarded in 2006.

Best Publications

  • Reiterative Use of the EGF Receptor Triggers Differentiation of All Cell Types in the Drosophila Eye

    Matthew Freeman

  • Feedback control of intercellular signalling in development

    Matthew Freeman

  • Sprouty, an Intracellular Inhibitor of Ras Signaling

    Tanita Casci;Javier Vinós;Matthew Freeman

  • Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases.

    Sinisa Urban;Jeffrey R. Lee;Matthew Freeman

  • Mitochondrial membrane remodelling regulated by a conserved rhomboid protease

    G. Angus McQuibban;Saroj Saurya;Matthew Freeman

  • Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila.

    Jeffrey R. Lee;Sinisa Urban;Clare F. Garvey;Matthew Freeman

  • Cell determination strategies in the Drosophila eye

    Matthew Freeman

  • Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE.

    Colin Adrain;Markus Zettl;Yonka Christova;Neil Taylor

  • The argos gene encodes a diffusible factor that regulates cell fate decisions in the drosophila eye

    Matthew Freeman;Christian Klämbt;Corey S. Goodman;Gerald M. Rubin

  • Substrate Specificity of Rhomboid Intramembrane Proteases Is Governed by Helix-Breaking Residues in the Substrate Transmembrane Domain

    Sinisa Urban;Matthew Freeman

  • Inhibition of Drosophila EGF receptor activation by the secreted protein Argos

    Ronen Schweitzer;Robert Howes;Richard Smith;Ben-Zion Shilo

  • A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands.

    Sinisa Urban;Jeffrey R. Lee;Matthew Freeman

  • An Autoregulatory Cascade of EGF Receptor Signaling Patterns the Drosophila Egg

    Jonathan D Wasserman;Matthew Freeman

  • The Notch signalling regulator Fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DxD

    Sean Munro;Matthew Freeman

  • ARGOS TRANSCRIPTION IS INDUCED BY THE DROSOPHILA EGF RECEPTOR PATHWAY TO FORM AN INHIBITORY FEEDBACK LOOP

    Myriam Golembo;Ronen Schweitzer;Matthew Freeman;Ben-Zion Shilo

  • Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases

    Marius K. Lemberg;Matthew Freeman

  • Sequence-Specific Intramembrane Proteolysis: Identification of a Recognition Motif in Rhomboid Substrates

    Kvido Strisovsky;Hayley J. Sharpe;Matthew Freeman

  • Multiple functions of the EGF receptor in Drosophila eye development

    María Domínguez;Jonathan D. Wasserman;Matthew Freeman

  • The dissociation of nuclear and centrosomal division in gnu, a mutation causing giant nuclei in Drosophila.

    Matthew Freeman;Christiane Nüsslein-Volhard;David M. Glover

  • A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling

    Jonathan D. Wasserman;Sinisa Urban;Matthew Freeman

Frequent Co-Authors

Sally A. Cowley
Sally A. Cowley University of Oxford
Richard Mott
Richard Mott University College London
David M. Glover
David M. Glover California Institute of Technology
Philip N. Rather
Philip N. Rather Emory University
Gerald M. Rubin
Gerald M. Rubin Howard Hughes Medical Institute
Xiang Zhang
Xiang Zhang University of Hong Kong
Anant B. Parekh
Anant B. Parekh University of Oxford
Mariann Bienz
Mariann Bienz MRC Laboratory of Molecular Biology
Ben-Zion Shilo
Ben-Zion Shilo Weizmann Institute of Science
Nicholas X. Fang
Nicholas X. Fang University of Hong Kong

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