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Molecular Biology

D-Index
48
Citations
11666
World Ranking
2665
National Ranking
206

Overview

Sally A. Cowley is affiliated with the University of Oxford in the United Kingdom. Their research spans several interconnected scientific fields, with a primary focus on Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience.

The main areas of study within their research portfolio include Molecular Biology, Neurology, Immunology, Genetics, and Cell Biology. These fields align closely with the topics they investigate, such as Neuroinflammation and Neurodegeneration Mechanisms, Pluripotent Stem Cells Research, and Immune Cells in Cancer.

Other significant subjects covered in their work include Parkinson's Disease Mechanisms and Treatments, Alzheimer's Disease Research and Treatments, CRISPR and Genetic Engineering, and Single-cell and Spatial Transcriptomics.

The scientist has contributed to various publication venues, reflecting the broad relevance and multidisciplinary nature of their work. The most frequent venues where they have published include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer's & Dementia
  • Stem Cell Reports
  • Scientific Reports
  • Nature Communications

Among their recent papers, the following notable publications stand out:

  • "Microglia states and nomenclature: A field at its crossroads," published in 2022 in Neuron
  • "Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality," published in 2022 in Glia
  • "Non-neuronal cells in amyotrophic lateral sclerosis - from pathogenesis to biomarkers," published in 2021 in Nature Reviews Neurology
  • "Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening," published in 2020 in International Journal of Molecular Sciences
  • "Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD," published in 2020 in Stem Cell Reports

The scientist collaborates frequently with several researchers, including:

  • William James
  • Jane Vowles
  • Richard Wade-Martins
  • Cathy Browne
  • Sam Washer

Best Publications

  • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

    Sally Cowley;Hugh Paterson;Pauline Kemp;Christopher J. Marshall

  • Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

    Norman W. Freshney;Lesley Rawlinson;François Guesdon;Elizabeth Jones

  • Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

    D.R. Alessi;Y. Saito;D.G. Campbell;P. Cohen

  • A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

    W Haenseler;S N Sansom;J Buchrieser;S E Newey

  • ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

    Hugo J.R. Fernandes;Elizabeth M. Hartfield;Helen C. Christian;Evangelia Emmanoulidou

  • Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions.

    Bonnie van Wilgenburg;Cathy Browne;Jane Vowles;Sally A. Cowley

  • C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

    Ruxandra Dafinca;Jakub Scaber;Nida'a Ababneh;Tatjana Lalic

  • The Mitogen-activated Protein Kinase Kinase MEK1 Stimulates a Pattern of Gene Expression Typical of the Hypertrophic Phenotype in Rat Ventricular Cardiomyocytes

    Judith Gillespie-Brown;Stephen J. Fuller;Marie A. Bogoyevitch;Sally Cowley

  • Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.

    Dario R. Alessi;Philip Cohen;Alan Ashworth;Sally Cowley

  • Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3

    Karl R. Karlsson;Sally Cowley;Fernando O. Martinez;Michael Shaw

  • Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes

    Charmaine Lang;Kieran R. Campbell;Brent J. Ryan;Phillippa Carling

  • Effects of the stem cell factor, c-kit ligand, on human megakaryocytic cells

    Hava Avraham;Edouard Vannier;Sally Cowley;Shuxian Jiang

  • LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

    Anetta Härtlova;Anetta Härtlova;Susanne Herbst;Susanne Herbst;Julien Peltier;Julien Peltier;Angela Rodgers

  • Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.

    Lihong Zhou;Elena Sokolskaja;Clare Jolly;William James

  • CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells.

    Rowan Flynn;Alexander Grundmann;Peter Renz;Walther Hänseler

  • The roles of apoptotic pathways in the low recovery rate after cryopreservation of dissociated human embryonic stem cells

    Xia Xu;Sally Cowley;Christopher J. Flaim;William James

  • Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neurons

    Sabrina M Heman-Ackah;Sabrina M Heman-Ackah;Sabrina M Heman-Ackah;Raquel Manzano;Jeroen J M Hoozemans;Wiep Scheper;Wiep Scheper

  • Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3.

    Masayuki Towatari;Gillian E. May;Richard Marais;Gordon R. Perkins

  • Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.

    Federico Zambon;Marta Cherubini;Hugo J R Fernandes;Charmaine Lang

  • Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single cell transcriptomics

    A E Handel;S Chintawar;T Lalic;E Whiteley

Frequent Co-Authors

William James
William James University of Oxford
Richard Wade-Martins
Richard Wade-Martins University of Oxford
Kevin Talbot
Kevin Talbot University of Oxford
Hava Avraham
Hava Avraham Northeastern University
Jerome E. Groopman
Jerome E. Groopman Beth Israel Deaconess Medical Center
Caleb Webber
Caleb Webber University of Oxford
John B. Davis
John B. Davis University of Oxford
Matthew Freeman
Matthew Freeman University of Oxford
Majlinda Lako
Majlinda Lako Newcastle University
Michele T.M. Hu
Michele T.M. Hu University of Oxford

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