World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
19609
World Ranking
5328
National Ranking
412

Overview

Jeremy Saklatvala is affiliated with the University of Oxford in the United Kingdom. Their research spans several interconnected fields, predominantly within the realm of Medicine. Key subfields in their work include Rheumatology, Biomaterials, Immunology and Allergy, Cell Biology, and Equine studies.

The scientist's contributions are primarily situated in the study of osteoarthritis mechanisms and treatments, with a notable focus on silk-based biomaterials and their applications. Their investigations also cover areas such as cell adhesion molecules, proteoglycans and glycosaminoglycans research, and veterinary equine medical research.

Their published papers include:

  • The Effects of Age and Cell Isolation on Collagen II Synthesis by Articular Chondrocytes: Evidence for Transcriptional and Posttranscriptional Regulation, 2020, BioMed Research International
  • Does decorin stabilize the extracellular matrix of articular cartilage and slow the progression of osteoarthritis?, 2021, Osteoarthritis and Cartilage
  • 105 HLA-C∗06:02 is associated with response to IL-23-targeting biologic therapies in psoriasis, 2025, Journal of Investigative Dermatology

Frequent coauthors collaborating with Jeremy Saklatvala include:

  • Vipin Asopa
  • Tonia L. Vincent
  • Nick Dand
  • Carol Smith

The venues where this scientist frequently publishes include:

  • BioMed Research International
  • Osteoarthritis and Cartilage
  • Journal of Investigative Dermatology

The scientist's research is heavily oriented toward exploring the biological and molecular mechanisms underlying osteoarthritis and related cartilage conditions, with some studies highlighting the role of extracellular matrix components and immune response factors. Their examination of biomarkers and therapeutic response in dermatological contexts further reflects a multidisciplinary approach integrating rheumatological and immunological perspectives.

Best Publications

  • Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

    Norman W. Freshney;Lesley Rawlinson;François Guesdon;Elizabeth Jones

  • p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes.

    Jonathan L.E. Dean;Matthew Brook;Andrew R. Clark;Jeremy Saklatvala

  • The p38 MAP kinase pathway as a therapeutic target in inflammatory disease.

    Jeremy Saklatvala

  • Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability.

    Kamal R. Mahtani;Matthew Brook;Jonathan L. E. Dean;Gareth Sully

  • Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade

    Marina Lasa;Kamal R. Mahtani;Andrew Finch;Gary Brewer

  • Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

    Sonya M. Abraham;Toby Lawrence;Anna Kleiman;Paul Warden

  • Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38

    Marina Lasa;Sonya M. Abraham;Christine Boucheron;Jeremy Saklatvala

  • The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.

    Jonathan L.E Dean;Gareth Sully;Andrew R Clark;Jeremy Saklatvala

  • Role for p38 Mitogen-activated Protein Kinase in Platelet Aggregation Caused by Collagen or a Thromboxane Analogue

    Jeremy Saklatvala;Lesley Rawlinson;Richard J. Waller;Simon Sarsfield

  • The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR.

    Jonathan L. E. Dean;Robin Wait;Kamal R. Mahtani;Gareth Sully

  • Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein.

    J Saklatvala;L M C Pilsworth;S J Sarsfield;J Gavrilovic

  • Posttranslational Regulation of Tristetraprolin Subcellular Localization and Protein Stability by p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Pathways

    M. Brook;C. R. Tchen;T. Santalucia;J. McIlrath

  • Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38

    Marina Lasa;Matthew Brook;Jeremy Saklatvala;Andrew R. Clark

  • A cartilage catabolic factor from synovium.

    J T Dingle;J Saklatvala;R Hembry;J Tyler

  • Prevalence of radiographic osteoarthritis—it all depends on your point of view

    R. C. Duncan;E. M. Hay;J. Saklatvala;P. R. Croft

  • Transcriptional and post-transcriptional control of gene expression in inflammation.

    Michael Kracht;Jeremy Saklatvala

  • T Cell Proliferation in Response to Interleukins 2 and 7 Requires p38MAP Kinase Activation

    James B. Crawley;Lesley Rawlinson;Ferdinand V. Lali;Theresa H. Page

  • Regulation of tumour necrosis factor α mRNA stability by the mitogen-activated protein kinase p38 signalling cascade

    Matthew Brook;Gareth Sully;Andrew R Clark;Jeremy Saklatvala

  • Basic FGF mediates an immediate response of articular cartilage to mechanical injury.

    Tonia Vincent;Monika Hermansson;Mark Bolton;Robin Wait

  • Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38.

    Andrew R. Clark;Jonathan L.E. Dean;Jeremy Saklatvala

Frequent Co-Authors

Andrew R. Clark
Andrew R. Clark University of Birmingham
Robin Wait
Robin Wait Imperial College London
Hideaki Nagase
Hideaki Nagase University of Oxford
Michael Kracht
Michael Kracht University of Giessen
Andrew P. Cope
Andrew P. Cope King's College London
George Bou-Gharios
George Bou-Gharios University of Liverpool
Luke A. J. O'Neill
Luke A. J. O'Neill Trinity College Dublin
Guy S. Salvesen
Guy S. Salvesen Sanford Burnham Prebys Medical Discovery Institute
Peter Croft
Peter Croft Keele University
Elaine M. Hay
Elaine M. Hay Keele University

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