Brian M. J. Foxwell

Overview

Best Publications

• Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

  Kim Midwood;Sandra Sacre;Anna M Piccinini;Julia Inglis

  805
  Citations

• Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline.

  Niccolò Terrando;Claudia Monaco;Daqing Ma;Brian M. J. Foxwell

  801
  Citations

• Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis

  Jared M. Huston;Mahendar Ochani;Mauricio Rosas-Ballina;Hong Liao

  782
  Citations

• Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.

  Claudia Monaco;Evangelos Andreakos;Serafim Kiriakidis;Claudia Mauri

  525
  Citations

• Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease

  Andrew M. Smith;Farooq Z. Rahman;Bu'Hussain Hayee;Simon J. Graham

  508
  Citations

• Signalling, inflammation and arthritis NF-κB and its relevance to arthritis and inflammation

  R. E. Simmonds;B. M. Foxwell

  507
  Citations

• Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases.

  Andrew D. Foey;Sarah L. Parry;Lynn M. Williams;Marc Feldmann

  482
  Citations

• Signal Transducer and Activator of Transcription 3 Is the Dominant Mediator of the Anti-Inflammatory Effects of IL-10 in Human Macrophages

  Lynn Williams;Laura Bradley;Alexandra Smith;Brian Foxwell

  478
  Citations

• The Pyridinyl Imidazole Inhibitor SB203580 Blocks Phosphoinositide-dependent Protein Kinase Activity, Protein Kinase B Phosphorylation, and Retinoblastoma Hyperphosphorylation in Interleukin-2-stimulated T Cells Independently of p38 Mitogen-activated Protein Kinase

  Ferdinand V. Lali;Abigail E. Hunt;Sarah J. Turner;Brian M.J. Foxwell

  442
  Citations

• Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease.

  David A van Heel;Subrata Ghosh;Matt Butler;Karen A Hunt

  392
  Citations

• Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent.

  B Foxwell;K Browne;J Bondeson;C Clarke

  379
  Citations

• Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.

  Satomichi Yoshimura;Jan Bondeson;Brian M. J. Foxwell;Fionula M. Brennan

  360
  Citations

• VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2

  Serafim Kiriakidis;Evangelos Andreakos;Claudia Monaco;Brian Foxwell

  331
  Citations

• The role of toll-like receptors in chronic inflammation.

  Stefan K. Drexler;Brian M. Foxwell

  322
  Citations

• Interleukin-10 suppression of myeloid cell activation — a continuing puzzle

  Lynn M Williams;Giuseppe Ricchetti;Usha Sarma;Timothy Smallie

  313
  Citations

• T Cell Proliferation in Response to Interleukins 2 and 7 Requires p38MAP Kinase Activation

  James B. Crawley;Lesley Rawlinson;Ferdinand V. Lali;Theresa H. Page

  308
  Citations

• Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.

  Jan Bondeson;Brian Foxwell;Fionula Brennan;Marc Feldmann

  301
  Citations

• Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.

  Irina A. Udalova;Anna Richardson;Agnes Denys;Clive Smith

  301
  Citations

• Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis.

  Stefan K Drexler;Philip L Kong;Jeremy Wales;Brian M Foxwell

  288
  Citations

• Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP

  Evangelos Andreakos;Sandra M. Sacre;Clive Smith;Anna Lundberg

  277
  Citations