World's Best Scientists 2026 revealed!

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Immunology

D-Index
118
Citations
61045
World Ranking
350
National Ranking
223

Medicine

D-Index
118
Citations
61217
World Ranking
4008
National Ranking
2192

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Gary S. Firestein is affiliated with the University of California, San Diego in the United States. Their primary area of research is Medicine, with a focused specialization in Rheumatology, where they have contributed extensively to advancing the understanding of autoimmune and inflammatory disorders.

Firestein's work includes research spanning several subfields, notably Rheumatology, Immunology, Molecular Biology, Hematology, and Public Health, Environmental and Occupational Health. These fields reflect a multidisciplinary approach to studying complex immune-mediated diseases.

The scientist's publication record highlights frequent contributions to prominent venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Journal of Clinical and Translational Science
  • Annals of the Rheumatic Diseases
  • Arthritis & Rheumatology

Firestein's recent papers address key topics within rheumatoid arthritis and related immunological disorders. Notable publications include:

  • "Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes" (2020), Nature Reviews Rheumatology
  • "The pathogenesis of rheumatoid arthritis" (2022), Immunity
  • "Rheumatoid Arthritis - Common Origins, Divergent Mechanisms" (2023), New England Journal of Medicine
  • "Notch signalling drives synovial fibroblast identity and arthritis pathology" (2020), Nature
  • "Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes" (2023), Nature

Their frequent coauthors include David L. Boyle, V. Michael Holers, Kevin D. Deane, Jennifer H. Anolik, and Deepak A. Rao. Collaboration with these researchers suggests a network of inquiry focused largely on immunology and rheumatoid arthritis research.

Within their main topics of work, Firestein has concentrated on:

  • Rheumatoid Arthritis Research and Therapies
  • Systemic Lupus Erythematosus Research
  • Autoimmune and Inflammatory Disorders Research
  • T-cell and B-cell Immunology
  • Monoclonal and Polyclonal Antibodies Research
  • Lymphoma Diagnosis and Treatment
  • Mosquito-borne diseases and control

Over their career, Firestein has been recognized as a Member of the Association of American Physicians, reflecting professional acknowledgment within the medical research community.

Best Publications

  • NF-κB: a key role in inflammatory diseases

    Paul P. Tak;Gary S. Firestein

  • Evolving concepts of rheumatoid arthritis

    Gary S. Firestein

  • Rheumatoid arthritis

    Unknown

  • HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation

    Thorsten Cramer;Yuji Yamanishi;Björn E Clausen;Irmgard Förster

  • Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

    Beatrix Bartok;Gary S. Firestein

  • Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.

    Fan Zhang;Kevin Wei;Kamil Slowikowski;Chamith Y Fonseka

  • Immunopathogenesis of Rheumatoid Arthritis

    Gary S. Firestein;Iain B. McInnes

  • c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

    Zuoning Han;David L. Boyle;Lufen Chang;Brydon Bennett

  • Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

    Nunzio Bottini;Gary S. Firestein

  • Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes

    Gyrid Nygaard;Gary S. Firestein

  • Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?

    Gary S. Firestein

  • How important are T cells in chronic rheumatoid synovitis

    Gary S. Firestein;Nathan J. Zvaifler

  • Quantitative analysis of cytokine gene expression in rheumatoid arthritis.

    GS Firestein;JM Alvaro-Gracia;R Maki

  • Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

    Hal M Hoffman;Hal M Hoffman;Sanna Rosengren;David L Boyle;Jae Y Cho

  • The pathogenesis of rheumatoid arthritis

    Unknown

  • Rheumatoid Arthritis — Common Origins, Divergent Mechanisms

    Unknown

  • Apoptosis in rheumatoid arthritis synovium.

    Gary S. Firestein;Michele Yeo;Nathan J. Zvaifler

  • AP-1 and NF-KB Regulation in Rheumatoid Arthritis and Murine Collagen-Induced Arthritis

    Zuoning Han;D. L. Boyle;A. M. Manning;G. S. Firestein

  • A new murine CD4+ T cell subset with an unrestricted cytokine profile.

    G S Firestein;W D Roeder;J A Laxer;K S Townsend

  • Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium

    Gary S. Firestein;Fernando Echeverri;Michele Yeo;Nathan J. Zvaifler

  • Expression and function of wingless and frizzled homologs in rheumatoid arthritis

    Malini Sen;Kevin Lauterbach;Hani El-Gabalawy;Gary S. Firestein

  • Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors.

    F G Sajjadi;K Takabayashi;A C Foster;R C Domingo

  • Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics.

    D H Broide;M M Paine;G S Firestein

Frequent Co-Authors

David L. Boyle
David L. Boyle University of California, San Diego
Nathan J. Zvaifler
Nathan J. Zvaifler University of California, San Diego
Maripat Corr
Maripat Corr University of California, San Diego
Paul P. Tak
Paul P. Tak GlaxoSmithKline (United Kingdom)
Wei Wang
Wei Wang University of California, San Diego
Nunzio Bottini
Nunzio Bottini University of California, San Diego
Danielle M. Gerlag
Danielle M. Gerlag UCB Pharma (United Kingdom)
Linda S. Sorkin
Linda S. Sorkin University of California, San Diego
Douglas R. Green
Douglas R. Green St. Jude Children's Research Hospital
Robert L. Sah
Robert L. Sah University of California, San Diego

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For quicker entry into the nursing field, exploring easy lpn programs to get into can be valuable. Licensed Practical Nurses often assist in immunology-related healthcare settings, supporting patient care and laboratory work.

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