World's Best Scientists 2026 revealed!
Frank Luyten

Frank Luyten

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Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
97
Citations
34622
World Ranking
1750
National Ranking
31

Medicine

D-Index
97
Citations
34833
World Ranking
9279
National Ranking
103

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award

Overview

Frank Luyten is affiliated with KU Leuven in Belgium and has contributed extensively to the fields of medicine and engineering, with a significant focus on rheumatology and biomedical engineering. Their research encompasses several subfields including surgery, molecular biology, and epidemiology.

The scientist's work addresses various aspects of osteoarthritis, bone tissue engineering, and musculoskeletal treatments. Main topics covered in their research include:

  • Osteoarthritis Treatment and Mechanisms
  • 3D Printing in Biomedical Research
  • Bone fractures and treatments
  • Knee injuries and reconstruction techniques
  • Bone Tissue Engineering Materials
  • Mesenchymal stem cell research
  • Total Knee Arthroplasty Outcomes

Frequent publication venues for their research are:

  • Cytotherapy
  • Bone
  • Osteoarthritis and Cartilage
  • Biofabrication
  • bioRxiv (Cold Spring Harbor Laboratory)

Notable recent papers include:

  • "Early-stage symptomatic osteoarthritis of the knee - time for action" (2021, Nature Reviews Rheumatology)
  • "Epidemiology of knee osteoarthritis in general practice: a registry-based study" (2020, BMJ Open)
  • "Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects" (2021, Stem Cell Research & Therapy)
  • "Patterned, organoid-based cartilaginous implants exhibit zone specific functionality forming osteochondral-like tissues in vivo" (2021, Biomaterials)
  • "Towards classification criteria for early-stage knee osteoarthritis: A population-based study to enrich for progressors" (2020, Seminars in Arthritis and Rheumatism)

They have collaborated extensively with a number of frequent coauthors, including:

  • Liesbet Geris
  • Ioannis Papantoniou
  • Gabriella Nilsson Hall
  • Sabine Verschueren
  • Marina Maréchal

Best Publications

  • Multipotent mesenchymal stem cells from adult human synovial membrane

    Cosimo De Bari;Francesco Dell'Accio;Przemyslaw Tylzanowski;Frank P. Luyten

  • Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives.

    Antalya Ho-Shui-Ling;Johanna Bolander;Laurence E. Rustom;Amy Wagoner Johnson

  • Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components

    Slobodan Vukicevic;Hynda K. Kleinman;Frank P. Luyten;Anita B. Roberts

  • Treatment of Symptomatic Cartilage Defects of the Knee Characterized Chondrocyte Implantation Results in Better Clinical Outcome at 36 Months in a Randomized Trial Compared to Microfracture

    Daniel B. F. Saris;Johan Vanlauwe;Jan Victor;Karl Fredrik Almqvist

  • The bone–cartilage unit in osteoarthritis

    Rik J. Lories;Frank P. Luyten

  • Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8

    Shouwen Wang;Marie Krinks;Keming Lin;Frank P Luyten

  • Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane

    Cosimo De Bari;Francesco Dell'Accio;Frank Vandenabeele;Joris R. Vermeesch

  • Characterized Chondrocyte Implantation Results in Better Structural Repair When Treating Symptomatic Cartilage Defects of the Knee in a Randomized Controlled Trial Versus Microfracture

    Daniel B. F. Saris;Johan Vanlauwe;Jan Victor;Miroslav Haspl

  • Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development.

    S. C. Chang;B. Hoang;J. T. Thomas;S. Vukicevic

  • Purification and partial amino acid sequence of osteogenin, a protein initiating bone differentiation.

    F P Luyten;N S Cunningham;S Ma;N Muthukumaran

  • Mesenchymal multipotency of adult human periosteal cells demonstrated by single‐cell lineage analysis

    Cosimo De Bari;Francesco Dell'Accio;Johan Vanlauwe;Jeroen Eyckmans

  • A human chondrodysplasia due to a mutation in a TGF-beta superfamily member

    Thomas Jt;Lin K;Nandedkar M;Camargo M

  • Mechanisms of GDF-5 action during skeletal development.

    P.H. Francis-West;A. Abdelfattah;P. Chen;C. Allen

  • Cartilage-derived morphogenetic proteins

    Frank P. Luyten;Malcolm Moos;Steven Chao-Huan Chang

  • Human periosteum‐derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age

    Cosimo De Bari;Francesco Dell'Accio;Frank P. Luyten

  • Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo

    Francesco Dell'Accio;Cosimo De Bari;Frank P. Luyten

  • Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1

    Thomas Jt;Kilpatrick Mw;Lin K;Erlacher L

  • Five-Year Outcome of Characterized Chondrocyte Implantation Versus Microfracture for Symptomatic Cartilage Defects of the Knee Early Treatment Matters

    Johan Vanlauwe;Daniel B F Saris;Daniel B F Saris;Jan Victor;Karl Fredrik Almqvist

  • Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis

    Rik J.U. Lories;Inge Derese;Frank P. Luyten

  • Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants

    Frank P. Luyten;Vincent C. Hascall;S.Peter Nissley;Teresa I. Morales

Frequent Co-Authors

Rik Lories
Rik Lories KU Leuven
Liesbet Geris
Liesbet Geris University of Liège
Ilse Jonkers
Ilse Jonkers KU Leuven
A. H. Reddi
A. H. Reddi University of California, Davis
Ana M. Valdes
Ana M. Valdes University of Nottingham
Costantino Pitzalis
Costantino Pitzalis Queen Mary University of London
Ingileif Jonsdottir
Ingileif Jonsdottir deCODE Genetics (Iceland)
Kari Stefansson
Kari Stefansson deCODE Genetics (Iceland)
David T. Felson
David T. Felson Boston University

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