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Genetics

D-Index
66
Citations
14179
World Ranking
2631
National Ranking
335

Overview

John Loughlin is affiliated with Newcastle University in the United Kingdom and has a significant publication record primarily in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their research encompasses numerous subfields, including Rheumatology, Cancer Research, Molecular Biology, Genetics, and Oncology.

The scientist's research focuses on a variety of topics related to osteoarthritis and cancer. Major themes include:

  • Osteoarthritis Treatment and Mechanisms
  • Cancer-related molecular mechanisms research
  • Inflammatory mediators and NSAID effects
  • Cytokine Signaling Pathways and Interactions
  • Rheumatoid Arthritis Research and Therapies
  • Cancer-related gene regulation
  • Genetic Associations and Epidemiology

John Loughlin has published in several journals, with frequent contributions to the following venues:

  • Osteoarthritis and Cartilage
  • Arthritis & Rheumatology
  • Osteoarthritis and Cartilage Open
  • Arthritis Research & Therapy
  • Lara D. Veeken

Recent scientific papers include:

  • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations, 2021, Cell
  • Interplay between genetics and epigenetics in osteoarthritis, 2020, Nature Reviews Rheumatology
  • Genetics of osteoarthritis, 2021, Osteoarthritis and Cartilage
  • Cohort profile: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers, 2020, BMJ Open
  • Multi-classifier prediction of knee osteoarthritis progression from incomplete imbalanced longitudinal data, 2020, Scientific Reports

Their research collaborations include frequent co-authorship with the following individuals:

  • Sarah J. Rice
  • Eleanor Parker
  • David J. Deehan
  • Ali Mobasheri
  • Yulia S. Kehayova

Best Publications

  • Genetic influences on osteoarthritis in women: a twin study

    Tim D Spector;Flavia Cicuttini;Juliet Baker;John Loughlin

  • Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females

    John Loughlin;Barbara Dowling;Kay Chapman;Lucy Marcelline

  • Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency

    Rachel Emma Dickinson;Helen Griffin;Venetia Bigley;Louise N. Reynard

  • Identification of new susceptibility loci for osteoarthritis (arcOGEN): A genome-wide association study

    E Zeggini;K Panoutsopoulou

  • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

    Cindy G Boer;Konstantinos Hatzikotoulas;Lorraine Southam;Lilja Stefánsdóttir

  • Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee

    Ana M. Valdes;John Loughlin;Mark Van Oene;Kay Chapman

  • Mutations in Fibroblast Growth-Factor Receptor 3 in Sporadic Cases of Achondroplasia Occur Exclusively on the Paternally Derived Chromosome

    Douglas J. Wilkin;Jinny K. Szabo;Rhoda Cameron;Shirley Henderson

  • A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.

    Hanneke J M Kerkhof;Rik J Lories;Ingrid Meulenbelt;Ingileif Jonsdottir

  • Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis

    Ingrid Meulenbelt;Josine L. Min;Steffan Bos;Naghmeh Riyazi

  • Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand

    Evangelos Evangelou;Kay Chapman;Ingrid Meulenbelt;Fotini B. Karassa

  • An SNP in the 5′-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage

    Lorraine Southam;Julio Rodriguez-Lopez;James M. Wilkins;Manuel Pombo-Suarez

  • Mutations in the region encoding the von Willebrand factor A domain of matrilin-3 are associated with multiple epiphyseal dysplasia.

    Kathryn L. Chapman;Geert R. Mortier;Kay Chapman;John Loughlin

  • A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5′ UTR of GDF5 with osteoarthritis susceptibility

    Kay Chapman;Atsushi Takahashi;Ingrid Meulenbelt;Chris Watson

  • Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women.

    Ana M. Valdes;Mark Van Oene;Deborah J. Hart;Gabriela L. Surdulescu

  • The genetic epidemiology of human primary osteoarthritis: current status.

    John Loughlin

  • Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

    Evangelos Evangelou;Ana M. Valdes;Hanneke J. M. Kerkhof;Unnur Styrkarsdottir

  • Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women.

    Arjan P. Bergink;Joyce B. van Meurs;John Loughlin;Pascal P. Arp

  • Recent advances in the genetic investigation of osteoarthritis.

    Chris A. Peach;Andrew J. Carr;John Loughlin

  • Characterization of the Cartilage DNA Methylome in Knee and Hip Osteoarthritis

    Michael D. Rushton;Louise N. Reynard;Matt J. Barter;Ramsay Refaie

  • GENETIC INFLUENCES IN END-STAGE OSTEOARTHRITIS: SIBLING RISKS OF HIP AND KNEE REPLACEMENT FOR IDIOPATHIC OSTEOARTHRITIS

    Jai Chitnavis;Janet S. Sinsheimer;Kim Clipsham;John Loughlin

Frequent Co-Authors

Andrew Carr
Andrew Carr University of Oxford
Ingrid Meulenbelt
Ingrid Meulenbelt Leiden University Medical Center
Eleftheria Zeggini
Eleftheria Zeggini Technical University of Munich
Kari Stefansson
Kari Stefansson deCODE Genetics (Iceland)
Tim D. Spector
Tim D. Spector King's College London
Antonio Gonzalez
Antonio Gonzalez University of Santiago de Compostela
Margreet Kloppenburg
Margreet Kloppenburg Leiden University Medical Center
Ingileif Jonsdottir
Ingileif Jonsdottir deCODE Genetics (Iceland)
Ana M. Valdes
Ana M. Valdes University of Nottingham
Juan J. Gomez-Reino
Juan J. Gomez-Reino University of Santiago de Compostela

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