Nunzio Bottini mainly investigates Protein tyrosine phosphatase, PTPN22, Immunology, Autoimmunity and Cell biology. His Phosphatase research extends to Protein tyrosine phosphatase, which is thematically connected. The study incorporates disciplines such as Internal medicine, Allele and T-cell receptor in addition to PTPN22.
His Allele research includes themes of SNP and Autoimmune disease. His studies in Autoimmunity integrate themes in fields like Innate immune system and Antigen. Nunzio Bottini focuses mostly in the field of Cell biology, narrowing it down to matters related to Tyrosine and, in some cases, Neuroscience.
His scientific interests lie mostly in Protein tyrosine phosphatase, Immunology, Internal medicine, Biochemistry and Genetics. His Protein tyrosine phosphatase study frequently draws connections to adjacent fields such as Phosphatase. His research in Immunology intersects with topics in PTPN22 and Cancer research.
His PTPN22 study combines topics in areas such as Case-control study and Allele frequency. Nunzio Bottini interconnects Diabetes mellitus, Endocrinology and Genotype in the investigation of issues within Internal medicine. His work deals with themes such as T cell, T-cell receptor and Adipogenesis, which intersect with Cell biology.
His main research concerns Protein tyrosine phosphatase, Cancer research, Phosphatase, Cell biology and Phosphorylation. Biochemistry and Tyrosine are inherently bound to his Protein tyrosine phosphatase studies. His research integrates issues of Tumor necrosis factor alpha, Rheumatoid arthritis, Immunology, Arthritis and Gene knockdown in his study of Cancer research.
His Rheumatoid arthritis research includes elements of Inflammation, PTPN22, Allele and Myeloid. His Phosphatase study incorporates themes from Clonal anergy and Allosteric regulation. The Cell biology study combines topics in areas such as Interleukin 2, CD8, Antigen and T-cell receptor.
Nunzio Bottini mainly focuses on Arthritis, Phosphatase, Biochemistry, Protein tyrosine phosphatase and Tyrosine. His Arthritis study combines topics in areas such as Interferon gamma, Cytokine, Natural killer T cell, ZAP70 and Signal transduction. His Phosphatase study introduces a deeper knowledge of Phosphorylation.
His Biochemistry study frequently draws connections between related disciplines such as Computational biology. His Type 2 diabetes study often links to related topics such as Pharmacology. The various areas that he examines in his Pharmacology study include Human serum albumin, Methotrexate, Drug delivery, Albumin and Cysteine.
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Protein Tyrosine Phosphatases in the Human Genome
Andres Alonso;Joanna Sasin;Nunzio Bottini;Ilan Friedberg.
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
Nunzio Bottini;Lucia Musumeci;Andres Alonso;Souad Rahmouni.
Nature Genetics (2004)
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.
Torkel Vang;Mauro Congia;Maria Doloretta Macis;Lucia Musumeci.
Nature Genetics (2005)
Multi-walled carbon nanotubes induce T lymphocyte apoptosis
Massimo Bottini;Shane Bruckner;Konstantina Nika;Nunzio Bottini.
Toxicology Letters (2006)
Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors
Nunzio Bottini;Gary S. Firestein.
Nature Reviews Rheumatology (2013)
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
Suna Onengut-Gumuscu;Wei-Min Chen;Oliver Burren;Nick J Cooper.
Nature Genetics (2015)
Role of PTPN22 in type 1 diabetes and other autoimmune diseases.
Nunzio Bottini;Torkel Vang;Francesco Cucca;Francesco Cucca;Tomas Mustelin.
Seminars in Immunology (2006)
Protein tyrosine phosphatases and the immune response
Tomas Mustelin;Torkel Vang;Nunzio Bottini.
Nature Reviews Immunology (2005)
PEG-Modified Carbon Nanotubes in Biomedicine: Current Status and Challenges Ahead
Massimo Bottini;Nicola Rosato;Nunzio Bottini.
Protein tyrosine phosphatase PTPN22 in human autoimmunity
Torkel Vang;Ana V. Miletic;Nunzio Bottini;Tomas Mustelin.
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