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Biology and Biochemistry

D-Index
60
Citations
16422
World Ranking
11780
National Ranking
5066

Overview

Nunzio Bottini is affiliated with the University of California, San Diego in the United States. Their research spans multiple scientific fields, with a primary focus on Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology.

The scientist's work addresses several subfields of study including Molecular Biology, Immunology, Rheumatology, Radiology, Nuclear Medicine and Imaging, and Genetics.

Key research topics in Nunzio Bottini's publications include:

  • Protein Tyrosine Phosphatases
  • Galectins and Cancer Biology
  • Rheumatoid Arthritis Research and Therapies
  • Monoclonal and Polyclonal Antibodies Research
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Osteoarthritis Treatment and Mechanisms

Frequent co-authors who collaborated with Bottini include Stephanie M. Stanford, Nisarg J. Shah, Mattias N. D. Svensson, Eugenio Santelli, and Shen K. Yang.

The scientist's research has been published multiple times in prominent venues, with the most contributions appearing in:

  • Arthritis & Rheumatology
  • Journal of Biological Chemistry
  • Science Advances
  • JCI Insight
  • Science Signaling

Notable recent papers by Nunzio Bottini are:

  • "Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders," 2023, Nature Reviews Drug Discovery
  • "Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal," 2020, Science Advances
  • "Short-chain fatty acid-mediated epigenetic modulation of inflammatory T cells in vitro," 2022, Drug Delivery and Translational Research
  • "PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis," 2020, JCI Insight
  • "RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain," 2020, Journal of Biological Chemistry

Best Publications

  • Protein Tyrosine Phosphatases in the Human Genome

    Andres Alonso;Joanna Sasin;Nunzio Bottini;Ilan Friedberg

  • A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

    Nunzio Bottini;Lucia Musumeci;Andres Alonso;Souad Rahmouni

  • Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

    Nunzio Bottini;Gary S. Firestein

  • Multi-walled carbon nanotubes induce T lymphocyte apoptosis

    Massimo Bottini;Shane Bruckner;Konstantina Nika;Nunzio Bottini

  • Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

    Torkel Vang;Mauro Congia;Maria Doloretta Macis;Lucia Musumeci

  • Protein tyrosine phosphatases and the immune response.

    Tomas Mustelin;Torkel Vang;Nunzio Bottini

  • Role of PTPN22 in type 1 diabetes and other autoimmune diseases.

    Nunzio Bottini;Torkel Vang;Francesco Cucca;Francesco Cucca;Tomas Mustelin

  • PTPN22: the archetypal non-HLA autoimmunity gene.

    Stephanie M. Stanford;Nunzio Bottini

  • Surface polyethylene glycol conformation influences the protein corona of polyethylene glycol-modified single-walled carbon nanotubes: potential implications on biological performance.

    Cristiano Sacchetti;Khatereh Motamedchaboki;Andrea Magrini;Graziana Palmieri

  • PEG-Modified Carbon Nanotubes in Biomedicine: Current Status and Challenges Ahead

    Massimo Bottini;Nicola Rosato;Nunzio Bottini

  • Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and Disease

    Nunzio Bottini;Erik J. Peterson

  • Protein tyrosine phosphatase PTPN22 in human autoimmunity.

    Torkel Vang;Ana V Miletic;Nunzio Bottini;Tomas Mustelin

  • The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity

    Yaya Wang;Iftach Shaked;Stephanie M. Stanford;Wenbo Zhou

  • Targeting Tyrosine Phosphatases: Time to End the Stigma.

    Stephanie M. Stanford;Nunzio Bottini

  • Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes

    Martha B. Ladner;Nunzio Bottini;Ana M. Valdes;Janelle A. Noble

  • Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms.

    Nunzio Bottini;Egidio Bottini;Fulvia Gloria-Bottini;Tomas Mustelin

  • A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

    Valeria Orrú;Sophia J. Tsai;Blanca Rueda;Edoardo Fiorillo

  • Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH.

    Andres Alonso;Nunzio Bottini;Shane Bruckner;Souad Rahmouni

  • Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study

    Divya Krishnamurthy;Mark R. Karver;Edoardo Fiorillo;Valeria Orrú

  • Control of vesicle fusion by a tyrosine phosphatase.

    Huong Huynh;Nunzio Bottini;Scott Williams;Vera Cherepanov

Frequent Co-Authors

Tomas Mustelin
Tomas Mustelin University of Washington
Gary S. Firestein
Gary S. Firestein University of California, San Diego
Francesco Cucca
Francesco Cucca University of Sassari
David L. Boyle
David L. Boyle University of California, San Diego
Zhong Yin Zhang
Zhong Yin Zhang Purdue University West Lafayette
William B. Kiosses
William B. Kiosses La Jolla Institute For Allergy & Immunology
Paolo Curatolo
Paolo Curatolo University of Rome Tor Vergata
Ivan Mijakovic
Ivan Mijakovic Chalmers University of Technology
Javier Martín
Javier Martín Spanish National Research Council
Miguel A. González-Gay
Miguel A. González-Gay University of Cantabria

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