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Biology and Biochemistry

D-Index
100
Citations
38685
World Ranking
1506
National Ranking
850

Research.com Recognitions

  • 2010 - Member of the National Academy of Sciences

Overview

Michael D. Cahalan is affiliated with the University of California, Irvine in the United States. Their research primarily spans the fields of Neuroscience and Medicine, with a focus on several subfields including Neurology, Immunology, Molecular Biology, Physiology, and Sensory Systems.

The main topics covered in their body of work include Neuroinflammation and Neurodegeneration Mechanisms, Erythrocyte Function and Pathophysiology, Inflammation biomarkers and pathways, Ion Channels and Receptors, Ion channel regulation and function, Neurological Disease Mechanisms and Treatments, and Stress Responses and Cortisol.

Among the frequent coauthors collaborating with Michael D. Cahalan are Amit Jairaman, Shivashankar Othy, Mathew Blurton-Jones, Joseph L. Dynes, and Andriy V. Yeromin.

Michael D. Cahalan's regular publication venues include Nature Communications, Alzheimer s & Dementia, Proceedings of the National Academy of Sciences, bioRxiv (Cold Spring Harbor Laboratory), and The Journal of Immunology.

Notable recent papers authored or coauthored by Michael D. Cahalan are as follows:

  • Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing, 2021, Nature Communications
  • Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease, 2020, Nature Communications
  • Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses, 2022, Cell Reports
  • Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4 + T cell responses, 2021, Science Advances
  • Regulatory T cells promote remyelination in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis following human neural stem cell transplant, 2020, Neurobiology of Disease

Michael D. Cahalan was awarded membership in the National Academy of Sciences in 2010.

Best Publications

  • STIM1, an essential and conserved component of store-operated Ca2+ channel function

    Jack Roos;Paul J. DiGregorio;Andriy V. Yeromin;Kari Ohlsen

  • STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

    Shenyuan L. Zhang;Ying Yu;Jack Roos;J. Ashot Kozak

  • Two-photon imaging of lymphocyte motility and antigen response in intact lymph node.

    Mark J. Miller;Sindy H. Wei;Ian Parker;Michael D. Cahalan

  • iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

    Edsel M. Abud;Ricardo N. Ramirez;Eric S. Martinez;Luke M. Healy

  • Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.

    Shenyuan L. Zhang;Andriy V. Yeromin;Xiang H.-F. Zhang;Ying Yu

  • Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

    Andriy V. Yeromin;Shenyuan L. Zhang;Shenyuan L. Zhang;Weihua Jiang;Weihua Jiang;Ying Yu;Ying Yu

  • Voltage-gated K + channels in human T lymphocytes: a role in mitogenesis?

    Thomas E. DeCoursey;K. George Chandy;Sudhir Gupta;Michael D. Cahalan

  • Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: A potential immunosuppressant

    Heike Wulff;Mark J. Miller;Wolfram Hänsel;Stephan Grissmer

  • Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells

    Takaharu Okada;Mark J Miller;Ian Parker;Matthew F Krummel

  • The functional network of ion channels in T lymphocytes

    Michael D. Cahalan;K. George Chandy

  • Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes

    Mark J. Miller;Olga Safrina;Ian Parker;Michael D. Cahalan

  • Potassium and calcium channels in lymphocytes.

    Richard S Lewis;Michael D Cahalan

  • Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy

    Mark J. Miller;Sindy H. Wei;Michael D. Cahalan;Ian Parker

  • Two-photon tissue imaging: seeing the immune system in a fresh light.

    Michael D. Cahalan;Ian Parker;Sindy H. Wei;Mark J. Miller

  • STIMulating store-operated Ca(2+) entry.

    Michael D. Cahalan

  • K+ channels as targets for specific immunomodulation.

    K. George Chandy;Heike Wulff;Christine Beeton;Michael Pennington

  • T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node

    Mark J. Miller;Arsalan S. Hejazi;Sindy H. Wei;Michael D. Cahalan

  • Polarity of T Cell Shape, Motility, and Sensitivity to Antigen

    Paul A. Negulescu;Tatiana B. Krasieva;Abrar Khan;Hubert H. Kerschbaum

  • Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells.

    R S Lewis;M D Cahalan

  • Cell-to-cell spread of calcium signals mediated by ATP receptors in mast cells.

    Yuri Osipchuk;Michael Cahalan

Frequent Co-Authors

Ian Parker
Ian Parker University of California, Irvine
K. George Chandy
K. George Chandy Nanyang Technological University
George A. Gutman
George A. Gutman University of California, Irvine
Mark J. Miller
Mark J. Miller Washington University in St. Louis
Heike Wulff
Heike Wulff University of California, Davis
Michael W. Pennington
Michael W. Pennington University of Florida
Richard S. Lewis
Richard S. Lewis Stanford University
Sudhir Gupta
Sudhir Gupta University of California, Irvine
Thomas E. DeCoursey
Thomas E. DeCoursey Rush University
Vikram G. Shakkottai
Vikram G. Shakkottai The University of Texas Southwestern Medical Center

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