D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 51 Citations 8,770 123 World Ranking 12654 National Ranking 5386

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Amino acid
  • Biochemistry

Michael W. Pennington spends much of his time researching Potassium channel, Peptide, Pharmacology, Stichodactyla helianthus and Potassium channel blocker. His research integrates issues of Toxin, Biochemistry and Cell biology in his study of Potassium channel. The Peptide study combines topics in areas such as Amino acid, Stereochemistry and Venom.

His Pharmacology research incorporates themes from Experimental autoimmune encephalomyelitis, Endocrinology, Internal medicine and Channel blocker. His Stichodactyla helianthus study integrates concerns from other disciplines, such as Cell culture, Autoimmunity and Flow cytometry. Potassium channel blocker and Effector are frequently intertwined in his study.

His most cited work include:

  • Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases (410 citations)
  • K+ channels as targets for specific immunomodulation. (388 citations)
  • The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS (366 citations)

What are the main themes of his work throughout his whole career to date?

Michael W. Pennington mainly focuses on Potassium channel, Peptide, Stereochemistry, Biochemistry and Stichodactyla helianthus. His work carried out in the field of Potassium channel brings together such families of science as Toxin, Cell biology, Effector and Pharmacology. In his study, Calcium signaling is strongly linked to Immunology, which falls under the umbrella field of Cell biology.

His Pharmacology research is multidisciplinary, incorporating perspectives in In vitro, Rheumatoid arthritis and Immune system. His study explores the link between Peptide and topics such as Residue that cross with problems in Tyrosine. In his research, Protease is intimately related to Cleavage, which falls under the overarching field of Stereochemistry.

He most often published in these fields:

  • Potassium channel (36.76%)
  • Peptide (30.88%)
  • Stereochemistry (29.41%)

What were the highlights of his more recent work (between 2016-2020)?

  • Potassium channel (36.76%)
  • Pharmacology (15.44%)
  • Peptide (30.88%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Potassium channel, Pharmacology, Peptide, Stereochemistry and Cell biology. His work on BK channel as part of general Potassium channel study is frequently linked to Regulator, therefore connecting diverse disciplines of science. His research in Pharmacology intersects with topics in Rheumatoid arthritis, Venom and Mechanism of action.

His Peptide study deals with Cysteine intersecting with Proteolysis, Sea anemone and Potassium channel blocker. The various areas that he examines in his Stereochemistry study include Glycine and Chemical synthesis. His Cell biology research includes themes of Microglia, Receptor, Integrin, Cell adhesion and In vivo.

Between 2016 and 2020, his most popular works were:

  • Peptide therapeutics from venom: Current status and potential. (106 citations)
  • Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease (90 citations)
  • Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor (55 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Amino acid
  • Biochemistry

His primary scientific interests are in Pharmacology, Potassium channel, Neuroinflammation, Microglia and Cell biology. His Pharmacology research is multidisciplinary, relying on both Venom and Peptide. His study in Potassium channel is interdisciplinary in nature, drawing from both Protein kinase B, Phosphorylation, Integrin, Cell adhesion and KCNA3.

Michael W. Pennington has researched Neuroinflammation in several fields, including Transcriptome and Neuroscience. His Microglia study deals with the bigger picture of Immunology. His Cell biology research is multidisciplinary, incorporating elements of Fibroblast, Integrin alpha M, BK channel and T cell.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

Christine Beeton;Heike Wulff;Nathan E. Standifer;Philippe Azam.
Proceedings of the National Academy of Sciences of the United States of America (2006)

562 Citations

K+ channels as targets for specific immunomodulation.

K. George Chandy;Heike Wulff;Christine Beeton;Michael Pennington.
Trends in Pharmacological Sciences (2004)

542 Citations

The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS

Heike Wulff;Peter A. Calabresi;Rameeza Allie;Sung Yun.
Journal of Clinical Investigation (2003)

513 Citations

Selective blockade of T lymphocyte K+ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

Christine Beeton;Heike Wulff;Jocelyne Barbaria;Olivier Clot-Faybesse.
Proceedings of the National Academy of Sciences of the United States of America (2001)

397 Citations

ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide

Katalin Kalman;Michael W. Pennington;Mark D. Lanigan;Angela Nguyen.
Journal of Biological Chemistry (1998)

324 Citations

Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases

Christine Beeton;Michael W. Pennington;Heike Wulff;Satendra Singh.
Molecular Pharmacology (2005)

310 Citations

The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites *

Alexei F. Kisselev;Margarita Garcia-Calvo;Herman S. Overkleeft;Erin Peterson.
Journal of Biological Chemistry (2003)

238 Citations

Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections.

Xavier Lauth;Jeffrey J. Babon;Jason A. Stannard;Satendra Singh.
Journal of Biological Chemistry (2005)

235 Citations

K+ Channel Expression during B Cell Differentiation: Implications for Immunomodulation and Autoimmunity

Heike Wulff;Hans Günther Knaus;Michael Pennington;K. George Chandy.
Journal of Immunology (2004)

228 Citations

Imaging of Effector Memory T Cells during a Delayed-Type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block

Melanie P. Matheu;Christine Beeton;Adriana Garcia;Victor Chi.
Immunity (2008)

217 Citations

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