Michael W. Pennington

Overview

Best Publications

• Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

  Christine Beeton;Heike Wulff;Nathan E. Standifer;Philippe Azam

  631
  Citations

• K+ channels as targets for specific immunomodulation.

  K. George Chandy;Heike Wulff;Christine Beeton;Michael Pennington

  560
  Citations

• The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS

  Heike Wulff;Peter A. Calabresi;Rameeza Allie;Sung Yun

  543
  Citations

• Selective blockade of T lymphocyte K+ channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

  Christine Beeton;Heike Wulff;Jocelyne Barbaria;Olivier Clot-Faybesse

  432
  Citations

• ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide

  Katalin Kalman;Michael W. Pennington;Mark D. Lanigan;Angela Nguyen

  344
  Citations

• Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases

  Christine Beeton;Michael W. Pennington;Heike Wulff;Satendra Singh

  332
  Citations

• Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.

  Srikant Rangaraju;Eric B. Dammer;Syed Ali Raza;Priyadharshini Rathakrishnan

  327
  Citations

• Peptide therapeutics from venom: Current status and potential.

  Michael W. Pennington;Andrzej Czerwinski;Raymond S. Norton

  284
  Citations

• Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections.

  Xavier Lauth;Jeffrey J. Babon;Jason A. Stannard;Satendra Singh

  264
  Citations

• K+ Channel Expression during B Cell Differentiation: Implications for Immunomodulation and Autoimmunity

  Heike Wulff;Hans Günther Knaus;Michael Pennington;K. George Chandy

  261
  Citations

• Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

  Victor Chi;Michael William Pennington;Raymond Stanley Norton;Eric J Tarcha

  257
  Citations

• The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites *

  Alexei F. Kisselev;Margarita Garcia-Calvo;Herman S. Overkleeft;Erin Peterson

  253
  Citations

• Imaging of Effector Memory T Cells during a Delayed-Type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block

  Melanie P. Matheu;Christine Beeton;Adriana Garcia;Victor Chi

  249
  Citations

• Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone

  Jane E. Tudor;Paul K. Pallaghy;Michael W. Pennington;Raymond S. Norton

  221
  Citations

• Structural Conservation of the Pores of Calcium-activated and Voltage-gated Potassium Channels Determined by a Sea Anemone Toxin

  Heiko Rauer;Michael Pennington;Michael Cahalan;K. George Chandy

  176
  Citations

• Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes.

  M. W. Pennington;C. Beeton;C. A. Galea;B. J. Smith

  160
  Citations

• Three-dimensional Structure in Solution of the Calcium Channel Blocker ω-Conotoxin

  Paul K. Pallaghy;Brendan M. Duggan;Michael W. Pennington;Raymond S. Norton

  157
  Citations

• A Novel Fluorescent Toxin to Detect and Investigate Kv1.3 Channel Up-regulation in Chronically Activated T Lymphocytes

  Christine Beeton;Heike Wulff;Satendra Singh;Steve Botsko

  138
  Citations

• Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease.

  Eric J. Tarcha;Victor Chi;Ernesto J. Muñoz-Elías;David Bailey

  137
  Citations

• Structure-guided Transformation of Charybdotoxin Yields an Analog That Selectively Targets Ca2+-activated over Voltage-gated K+ Channels

  Heiko Rauer;Mark D. Lanigan;Michael W. Pennington;Jayashree Aiyar

  136
  Citations