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Biology and Biochemistry

D-Index
72
Citations
15758
World Ranking
6414
National Ranking
2995

Research.com Recognitions

  • 2015 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

William W. Metcalf is affiliated with the University of Illinois at Urbana-Champaign in the United States. Their research falls primarily within the field of Biochemistry, Genetics and Molecular Biology, with a substantial focus on Molecular Biology, Plant Science, Genetics, Ecology, and Pharmacology.

The scientist's work concentrates on topics including Bacterial Genetics and Biotechnology, Lipid Membrane Structure and Behavior, Metal-Catalyzed Oxygenation Mechanisms, Metalloenzymes and iron-sulfur proteins, Microbial Natural Products and Biosynthesis, Escherichia coli research studies, and Genomics and Phylogenetic Studies.

Recent publications by William W. Metcalf include:

  • antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation, 2023, Nucleic Acids Research
  • Discovery, structure and mechanism of a tetraether lipid synthase, 2022, Nature
  • Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans, 2020, PLoS Biology
  • A Phosphonate Natural Product Made by Pantoea ananatis is Necessary and Sufficient for the Hallmark Lesions of Onion Center Rot, 2021, mBio
  • Role of internal loop dynamics in antibiotic permeability of outer membrane porins, 2022, Proceedings of the National Academy of Sciences

Frequent coauthors in their publications include Paul J. Hergenrother, Archit Vasan, Nandan Haloi, Po-Chao Wen, and Emad Tajkhorshid.

William W. Metcalf's research has appeared repeatedly in prominent journals and venues such as bioRxiv (Cold Spring Harbor Laboratory), mBio, Proceedings of the National Academy of Sciences, Angewandte Chemie International Edition, and Angewandte Chemie.

In recognition of their contributions to the scientific community, William W. Metcalf was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2015.

Best Publications

  • A computational framework to explore large-scale biosynthetic diversity

    Jorge C. Navarro-Muñoz;Nelly Selem-Mojica;Michael W. Mullowney;Satria A. Kautsar

  • The Genome of M. Acetivorans Reveals Extensive Metabolic and Physiological Diversity

    James E. Galagan;Chad Nusbaum;Alice Roy;Matthew G. Endrizzi;Matthew G. Endrizzi;Matthew G. Endrizzi

  • Conditionally replicative and conjugative plasmids carrying lacZ alpha for cloning, mutagenesis, and allele replacement in bacteria.

    William W. Metcalf;Weihong Jiang;Larry L. Daniels;Soo Ki Kim

  • A roadmap for natural product discovery based on large-scale genomics and metabolomics

    James R. Doroghazi;Jessica C. Albright;Anthony W. Goering;Kou San Ju

  • Genetic analysis of pigment biosynthesis in Xanthobacter autotrophicus Py2 using a new, highly efficient transposon mutagenesis system that is functional in a wide variety of bacteria.

    Rachel A. Larsen;Marlena M. Wilson;Adam M. Guss;William W. Metcalf

  • Biosynthesis of Phosphonic and Phosphinic Acid Natural Products

    William W. Metcalf;Wilfred A. van der Donk;Wilfred A. van der Donk

  • Synthesis of Methylphosphonic Acid by Marine Microbes: A Source for Methane in the Aerobic Ocean

    William W Metcalf;Benjamin M. Griffin;Robert M. Cicchillo;Jiangtao Gao

  • Microbial metabolism of reduced phosphorus compounds.

    Andrea K. White;William W. Metcalf

  • A genetic system for Archaea of the genus Methanosarcina: Liposome-mediated transformation and construction of shuttle vectors

    William W. Metcalf;Jun Kai Zhang;Ethel Apolinario;Kevin R. Sowers

  • Anaerobic growth of Methanosarcina acetivorans C2A on carbon monoxide: An unusual way of life for a methanogenic archaeon

    Michael Rother;William W. Metcalf

  • Use of the rep technique for allele replacement to construct new Escherichia coli hosts for maintenance of R6Kλ origin plasmids at different copy numbers

    William W. Metcalf;Weihong Jiang;Barry L. Wanner

  • Energy Conservation via Hydrogen Cycling in the Methanogenic Archaeon Methanosarcina barkeri.

    Gargi Kulkarni;Thomas D. Mand;William W. Metcalf

  • Genetic analysis of the archaeon Methanosarcina barkeri Fusaro reveals a central role for Ech hydrogenase and ferredoxin in methanogenesis and carbon fixation

    Jörn Meuer;H. Craig Kuettner;Jun Kai Zhang;Reiner Hedderich

  • Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes

    James R Doroghazi;William W Metcalf

  • The Methanosarcina barkeri Genome: Comparative Analysis with Methanosarcina acetivorans and Methanosarcina mazei Reveals Extensive Rearrangement within Methanosarcinal Genomes

    Dennis L. Maeder;Iain Anderson;Thomas S. Brettin;David C. Bruce

  • Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

    Kou San Ju;Jiangtao Gao;James R. Doroghazi;Kwo Kwang A. Wang

  • Purification and Characterization of a Novel Phosphorus-oxidizing Enzyme from Pseudomonas stutzeri WM88

    Amaya M. Garcia Costas;Andrea K. White;William W. Metcalf

  • Molecular genetic analysis of phosphite and hypophosphite oxidation by Pseudomonas stutzeri WM88.

    William W. Metcalf;Ralph S. Wolfe

  • Involvement of the Escherichia coli phn (psiD) gene cluster in assimilation of phosphorus in the form of phosphonates, phosphite, Pi esters, and Pi.

    W W Metcalf;B L Wanner

  • Diversity and abundance of phosphonate biosynthetic genes in nature

    Xiaomin Yu;James R. Doroghazi;Sarath Chandra Janga;Jun Kai Zhang

Frequent Co-Authors

Wilfred A. van der Donk
Wilfred A. van der Donk University of Illinois at Urbana-Champaign
Neil L. Kelleher
Neil L. Kelleher Northwestern University
Barry L. Wanner
Barry L. Wanner Harvard University
Huimin Zhao
Huimin Zhao University of Illinois at Urbana-Champaign
Adam M. Guss
Adam M. Guss Oak Ridge National Laboratory
Satish K. Nair
Satish K. Nair University of Illinois at Urbana-Champaign
Paul M. Thomas
Paul M. Thomas Northwestern University
Kevin R. Sowers
Kevin R. Sowers University of Maryland, Baltimore County
Ralph S. Wolfe
Ralph S. Wolfe University of Illinois at Urbana-Champaign
Nathan D. Price
Nathan D. Price University of Illinois at Urbana-Champaign

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