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Philippe Bousso

Philippe Bousso

D-Index & Metrics

Immunology

D-Index
58
Citations
15142
World Ranking
3489
National Ranking
163

Research.com Recognitions

  • 2020 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Philippe Bousso is affiliated with the Institut Pasteur in France. Their research primarily focuses on immunology and oncology, with significant work bridging molecular biology and genetics within the context of immune responses and cancer.

The scientist has contributed extensively to the fields of Medicine and Immunology and Microbiology. Their research engages deeply with topics such as:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • Research on Leishmaniasis Studies
  • Immune cells in cancer
  • Phagocytosis and Immune Regulation

Frequent publication venues where their work appears include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The EMBO Journal
  • Nature Communications
  • Science Immunology
  • Nature Cancer

They have collaborated regularly with colleagues such as Zacarias Garcia, Fabrice Lemaı̂tre, Darragh Duffy, Béatrice Corre, and Étienne Patin.

Recent papers exemplify their focus and contributions:

  • A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity, 2021, Science Immunology
  • Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment, 2020, Nature Cancer
  • Smoking changes adaptive immunity with persistent effects, 2024, Nature
  • Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity, 2023, Nature Cancer
  • Inflammation triggers ILC3 patrolling of the intestinal barrier, 2022, Nature Immunology

Recognition of their professional standing is indicated by membership in scientific organizations including the Academia Europaea and the European Molecular Biology Organization (EMBO).

Best Publications

  • Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

    Marina Cavazzana-Calvo;Salima Hacein-Bey;Geneviève De Saint Basile;Fabian Gross

  • Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

    Philippe Bousso;Ellen Robey

  • Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths.

    Paul Bastard;Adrian Gervais;Adrian Gervais;Tom Le Voyer;Tom Le Voyer;Jérémie Rosain;Jérémie Rosain

  • Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide: A Large Fraction of T Cell Clones Escapes Clonal Deletion

    Cécile Bouneaud;Philippe Kourilsky;Philippe Bousso

  • T-cell activation by dendritic cells in the lymph node: lessons from the movies

    Philippe Bousso

  • Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy

    Philippe Bousso;Nirav R Bhakta;Richard S Lewis;Ellen A Robey

  • Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice

    Béatrice Breart;Fabrice Lemaître;Susanna Celli;Philippe Bousso

  • Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.

    Etienne Patin;Milena Hasan;Jacob Bergstedt;Vincent Rouilly

  • Preexisting BCG-Specific T Cells Improve Intravesical Immunotherapy for Bladder Cancer

    Claire Biot;Claire Biot;Claire Biot;Cyrill A. Rentsch;Cyrill A. Rentsch;Cyrill A. Rentsch;Joel R. Gsponer;Joel R. Gsponer;Joel R. Gsponer;Frédéric D. Birkhäuser

  • Individual Variations in the Murine T Cell Response to a Specific Peptide Reflect Variability in Naive Repertoires

    Philippe Bousso;Armanda Casrouge;John D Altman;Matthias Haury

  • Real-Time Manipulation of T Cell-Dendritic Cell Interactions In Vivo Reveals the Importance of Prolonged Contacts for CD4+ T Cell Activation

    Susanna Celli;Fabrice Lemaître;Fabrice Lemaître;Philippe Bousso;Philippe Bousso

  • Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.

    Darragh Duffy;Darragh Duffy;Vincent Rouilly;Valentina Libri;Milena Hasan

  • CD4 T cells integrate signals delivered during successive DC encounters in vivo

    Susanna Celli;Zacarias Garcia;Philippe Bousso

  • Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

    Petar Scepanovic;Petar Scepanovic;Cécile Alanio;Christian Hammer;Christian Hammer;Christian Hammer;Flavia Hodel;Flavia Hodel

  • The mechanism of anti-CD20–mediated B cell depletion revealed by intravital imaging

    Fabricio Montalvao;Zacarias Garcia;Susanna Celli;Béatrice Breart

  • Intravital Imaging Reveals Distinct Dynamics for Natural Killer and CD8+ T Cells during Tumor Regression

    Jacques Deguine;Jacques Deguine;Béatrice Breart;Béatrice Breart;Fabrice Lemaître;Fabrice Lemaître;James P. Di Santo

  • A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity

    Morgane Boulch;Morgane Boulch;Marine Cazaux;Marine Cazaux;Yann Loe-Mie;Ronan Thibaut;Ronan Thibaut

  • Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy.

    Susanna Celli;Susanna Celli;Matthew L Albert;Matthew L Albert;Philippe Bousso;Philippe Bousso

  • Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo.

    Hélène D. Moreau;Hélène D. Moreau;Hélène D. Moreau;Fabrice Lemaître;Fabrice Lemaître;Emmanuel Terriac;Georges Azar;Georges Azar

  • Regulatory T Cells Increase the Avidity of Primary CD8+ T Cell Responses and Promote Memory

    Luigia Pace;Andy Tempez;Catharina Arnold-Schrauf;Fabrice Lemaitre

  • Diversity, functionality, and stability of the T cell repertoire derived in vivo from a single human T cell precursor.

    Philippe Bousso;Volker Wahn;Iyadh Douagi;Gerd Horneff

Frequent Co-Authors

Philippe Kourilsky
Philippe Kourilsky Collège de France
James P. Di Santo
James P. Di Santo Institut Pasteur
Gérard Eberl
Gérard Eberl Université Paris Cité
Ellen A. Robey
Ellen A. Robey University of California, Berkeley
Olivier Schwartz
Olivier Schwartz Université Paris Cité
Olivier Lantz
Olivier Lantz Institute Curie
Caroline Demangel
Caroline Demangel Institut Pasteur
Lluis Quintana-Murci
Lluis Quintana-Murci Institut Pasteur
Jean-François Joanny
Jean-François Joanny Collège de France

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