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Genetics

D-Index
49
Citations
13757
World Ranking
3976
National Ranking
1719

Overview

Marcelo A. Nobrega is affiliated with the University of Chicago in the United States and conducts research primarily in the areas of biochemistry, genetics, molecular biology, and medicine. Their work encompasses several subfields, including molecular biology, genetics, physiology, immunology, and cardiology and cardiovascular medicine.

Their research covers a variety of topics with a focus on RNA research and splicing, asthma and respiratory diseases, IL-33, ST2, and ILC pathways, congenital heart defects research, RNA modifications and cancer, genetic associations and epidemiology, and genomics and chromatin dynamics.

Marcelo A. Nobrega's frequent co-authors include:

  • Carole Ober
  • Noboru J. Sakabe
  • Ivy Aneas
  • Débora R. Sobreira
  • Megan J. Puckelwartz

They have published in various venues, with a notable presence in:

  • Circulation Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cell Reports
  • Science Advances

Some recent papers by Marcelo A. Nobrega include:

  • Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5, 2021, Science
  • Genetic Variation in Enhancers Modifies Cardiomyopathy Gene Expression and Progression, 2021, Circulation
  • Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua, 2021, Cell Reports
  • Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing, 2023, Neuron
  • Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women, 2022, Alzheimer s & Dementia

Best Publications

  • Obesity-associated variants within FTO form long-range functional connections with IRX3

    Scott Smemo;Juan J. Tena;Kyoung Han Kim;Eric R. Gamazon

  • In vivo enhancer analysis of human conserved non-coding sequences

    Len A. Pennacchio;Len A. Pennacchio;Nadav Ahituv;Alan M. Moses;Shyam Prabhakar

  • Scanning Human Gene Deserts for Long-Range Enhancers

    Marcelo A. Nobrega;Marcelo A. Nobrega;Ivan Ovcharenko;Ivan Ovcharenko;Veena Afzal;Veena Afzal;Edward M. Rubin;Edward M. Rubin

  • Enhancers: five essential questions

    Len A. Pennacchio;Wendy Bickmore;Ann Dean;Marcelo A. Nobrega

  • ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes

    Ivan Ovcharenko;Marcelo A. Nobrega;Gabriela G. Loots;Lisa Stubbs

  • FTO-Mediated Formation of N6-Hydroxymethyladenosine and N6-Formyladenosine in Mammalian RNA

    Ye Fu;Guifang Jia;Xueqin Pang;Xueqin Pang;Richard N. Wang

  • Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation

    Joon Won Yoon;Yasuhiro Kita;Daniel J. Frank;Rebecca R. Majewski

  • Comparative genomics at the vertebrate extremes.

    Dario Boffelli;Marcelo A. Nobrega;Marcelo A. Nobrega;Edward M. Rubin;Edward M. Rubin

  • A Fine-Scale Chimpanzee Genetic Map from Population Sequencing

    Adam Auton;Adam Auton;Adi Fledel-Alon;Susanne Pfeifer;Oliver Venn

  • A Molecular Pathway Including Id2, Tbx5, and Nkx2-5 Required for Cardiac Conduction System Development

    Ivan P.G. Moskowitz;Jae B. Kim;Jae B. Kim;Meredith L. Moore;Cordula M. Wolf

  • Further delineation of the 15q13 microdeletion and duplication syndromes: a clinical spectrum varying from non-pathogenic to a severe outcome

    B W M van Bon;H C Mefford;B Menten;D A Koolen

  • An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer

    Nora F. Wasserman;Ivy Aneas;Marcelo A. Nobrega

  • Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers

    Valer Gotea;Axel Visel;John M. Westlund;Marcelo A. Nobrega

  • Evolution and functional classification of vertebrate gene deserts

    Ivan Ovcharenko;Gabriela G. Loots;Marcelo A. Nobrega;Ross C. Hardison

  • Megabase deletions of gene deserts result in viable mice

    Marcelo A. Nóbrega;Yiwen Zhu;Yiwen Zhu;Ingrid Plajzer-Frick;Ingrid Plajzer-Frick;Veena Afzal;Veena Afzal

  • A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers.

    Laila El Khattabi;Haiyan Zhao;Jens Kalchschmidt;Natalie Young

  • TCF7L2 is a master regulator of insulin production and processing

    Yuedan Zhou;Soo Young Park;Jing Su;Kathleen Bailey

  • Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease

    Scott Smemo;Luciene C. Campos;Ivan P. Moskowitz;José E. Krieger

  • A common genetic variant within SCN10A modulates cardiac SCN5A expression

    Malou van den Boogaard;Scott Smemo;Ozanna Burnicka-Turek;David E. Arnolds

  • Megabase deletions of gene deserts result in viable mice - eScholarship

    Marcelo A. Nobrega;Yiwen Zhu;Ingrid Plajzer-Frick;Veena Afzal

Frequent Co-Authors

Len A. Pennacchio
Len A. Pennacchio Lawrence Berkeley National Laboratory
Elizabeth M. McNally
Elizabeth M. McNally Northwestern University
Edward M. Rubin
Edward M. Rubin Joint Genome Institute
Howard J. Jacob
Howard J. Jacob AbbVie (United States)
Carole Ober
Carole Ober University of Chicago
Sylvia M. Evans
Sylvia M. Evans University of Montana
Richard J. Roman
Richard J. Roman University of Mississippi Medical Center
Gregory E. Crawford
Gregory E. Crawford Duke University
Ju Chen
Ju Chen University of California, San Diego
Graeme I. Bell
Graeme I. Bell University of Chicago

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